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Personal profile

Research interests

The scientific advances of the last decades have allowed reaching a molecular level understanding of an increasing number of (bio)chemical processes. This state of knowledge is only possible due to the development of numerous methodologies and studies that allow rationalizing, at the atomic level, the relationship between structure and function, and the role of intermolecular interactions in mediating all (bio)chemical processes.

My main research interests are related to the application and development of solution-state nuclear magnetic resonance (NMR) spectroscopy techniques for structural analysis and the study of intermolecular interactions in biological and chemical systems, in the context of functional analysis of catalytic systems and the understanding of molecular recognition processes.

My research has been conducted mainly around three subjects:

- The study of intermolecular interactions in chemical systems relevant to the rationalization of asymmetric transformations or catalysis;

- The study of intermolecular interactions in non-conventional solvents (ionic liquids and CO2) to rationalize solvation phenomena;

- The study of intermolecular interactions in biological systems for the rationalization of biocatalysis or in the context of drug design.

To explore these research subjects using the NMR technique it is necessary to develop methods that allow obtaining information about molecular structure and dynamics, and interaction mechanisms, in different experimental conditions, such as at high pressure, in heterogeneous mixtures, or highly concentrated solutions of complex composition. Therefore, related research interest has been the development of NMR methods to address these challenges, in particular, high-pressure NMR, diffusion NMR and techniques for the study of protein-ligand interactions.

A recent research theme is the study of intermolecular interactions involving proteins under macromolecular crowding conditions, comparable to those found in vivo. The objective is to better understand the balance between entropic and enthalpic contributions in molecular recognition processes in conditions similar to those found in vivo. This work may have important implications for rationalizing regulatory processes (allostery and signalling) and misfolding of proteins.

Education/Academic qualification

Physical-Chemistry, Habilitation, Universidade NOVA de Lisboa

Organic Chemistry, Doctorate, Universidade NOVA de Lisboa

Applied Chemistry, Faculdade de Ciências e Tecnologia (FCT)

Keywords

  • QD Chemistry

Fingerprint Dive into the research topics where Eurico José da Silva Cabrita is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
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Research Output at NOVA 1998 2019

  • 1419 Citations
  • 22 h-Index
  • 71 Article
  • 3 Chapter
  • 1 Conference contribution
  • 1 Letter
4 Citations (Scopus)

Correspondence on “Preorganization and Cooperation for Highly Efficient and Reversible Capture of Low-Concentration CO 2 by Ionic Liquids”

Zanatta, M., Simon, N. M., Santos, F. P. D., Corvo, M. C., Cabrita, E. J. & Dupont, J., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 382-385 4 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
2 Downloads (Pure)

Fast NMR method to probe solvent accessibility and disordered regions in proteins

Faustino, A. F., Barbosa, G. M., Silva, M., Castanho, M. A. R. B., Da Poian, A. T., Cabrita, E. J., Santos, N. C., Almeida, F. C. L. & Martins, I. C., 1 Dec 2019, In : Scientific Reports. 9, 1, 1647.

Research output: Contribution to journalArticle

Open Access
File
Intrinsically Disordered Proteins
Dengue Virus
Proteins
Inosine Diphosphate
Capsid Proteins
1 Citation (Scopus)
1 Downloads (Pure)

Hybrid ionic liquid-silica xerogels applied in CO2 capture

Aquino, A. S., Vieira, M. O., Ferreira, A. S. D., Cabrita, E. J., Einloft, S. & de Souza, M. O., 1 Jul 2019, In : Applied Sciences (Switzerland). 9, 13, 2614.

Research output: Contribution to journalArticle

Open Access
File
Ionic Liquids
Xerogels
xerogels
Ionic liquids
Silicon Dioxide
7 Citations (Scopus)
19 Downloads (Pure)
Open Access
File
Peptidoglycan
Gram-Positive Bacteria
Glutamine
Staphylococcus aureus
Glutaminase
3 Citations (Scopus)

Ion pair and solvation dynamics of [Bmim][BF4] + water system

Cascão, J., Silva, W., Ferreira, A. S. D. & Cabrita, E. J., 1 Feb 2018, In : Magnetic Resonance in Chemistry. 56, 2(SI), p. 127-139 13 p.

Research output: Contribution to journalArticle

Solvation
Anions
Cations
Negative ions
Ions

Prizes

Medalha "Vicente de Seabra"/"Vicente de Seabra" Medal

Eurico José da Silva Cabrita (Recipient), 2010

Prize: Prize (including medals and awards)

chemistry
Portugal
researchers

Activities 2015 2017

  • 4 Invited talk
  • 1 Oral presentation