• 1924 Citations
  • 24 h-Index
19982019

Research output per year

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Personal profile

Research interests

The scientific advances of the last decades have allowed reaching a molecular level understanding of an increasing number of (bio)chemical processes. This state of knowledge is only possible due to the development of numerous methodologies and studies that allow rationalizing, at the atomic level, the relationship between structure and function, and the role of intermolecular interactions in mediating all (bio)chemical processes.

My main research interests are related to the application and development of solution-state nuclear magnetic resonance (NMR) spectroscopy techniques for structural analysis and the study of intermolecular interactions in biological and chemical systems, in the context of functional analysis of catalytic systems and the understanding of molecular recognition processes.

My research has been conducted mainly around three subjects:

- The study of intermolecular interactions in chemical systems relevant to the rationalization of asymmetric transformations or catalysis;

- The study of intermolecular interactions in non-conventional solvents (ionic liquids and CO2) to rationalize solvation phenomena;

- The study of intermolecular interactions in biological systems for the rationalization of biocatalysis or in the context of drug design.

To explore these research subjects using the NMR technique it is necessary to develop methods that allow obtaining information about molecular structure and dynamics, and interaction mechanisms, in different experimental conditions, such as at high pressure, in heterogeneous mixtures, or highly concentrated solutions of complex composition. Therefore, related research interest has been the development of NMR methods to address these challenges, in particular, high-pressure NMR, diffusion NMR and techniques for the study of protein-ligand interactions.

A recent research theme is the study of intermolecular interactions involving proteins under macromolecular crowding conditions, comparable to those found in vivo. The objective is to better understand the balance between entropic and enthalpic contributions in molecular recognition processes in conditions similar to those found in vivo. This work may have important implications for rationalizing regulatory processes (allostery and signalling) and misfolding of proteins.

Education/Academic qualification

Physical-Chemistry, Habilitation, Universidade NOVA de Lisboa

Organic Chemistry, Doctorate, Universidade NOVA de Lisboa

Applied Chemistry, Faculdade de Ciências e Tecnologia (FCT)

Keywords

  • QD Chemistry

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Research Output at NOVA

  • 1924 Citations
  • 24 h-Index
  • 76 Article
  • 3 Chapter
  • 1 Conference contribution
  • 1 Letter

Correspondence on “Preorganization and Cooperation for Highly Efficient and Reversible Capture of Low-Concentration CO 2 by Ionic Liquids”

Zanatta, M., Simon, N. M., Santos, F. P. D., Corvo, M. C., Cabrita, E. J. & Dupont, J., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 382-385 4 p.

Research output: Contribution to journalLetter

7 Citations (Scopus)

Fast NMR method to probe solvent accessibility and disordered regions in proteins

Faustino, A. F., Barbosa, G. M., Silva, M., Castanho, M. A. R. B., Da Poian, A. T., Cabrita, E. J., Santos, N. C., Almeida, F. C. L. & Martins, I. C., 1 Dec 2019, In : Scientific Reports. 9, 1, 1647.

Research output: Contribution to journalArticle

Open Access
File
  • 2 Citations (Scopus)
    3 Downloads (Pure)

    Hybrid ionic liquid-silica xerogels applied in CO2 capture

    Aquino, A. S., Vieira, M. O., Ferreira, A. S. D., Cabrita, E. J., Einloft, S. & de Souza, M. O., 1 Jul 2019, In : Applied Sciences (Switzerland). 9, 13, 2614.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    1 Downloads (Pure)
  • RNA G-quadruplex as supramolecular carrier for cancer-selective delivery

    Santos, T., Pereira, P., Campello, M. P. C., Paulo, A., Queiroz, J. A., Cabrita, E. & Cruz, C., 1 Sep 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 473-479 7 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Prizes

    Medalha "Vicente de Seabra"/"Vicente de Seabra" Medal

    Eurico José da Silva Cabrita (Recipient), 2010

    Prize: Prize (including medals and awards)

  • Activities

    • 4 Invited talk
    • 1 Oral presentation