• 2140 Citations
  • 25 h-Index
20102020

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Personal profile

Research interests

Our long term goal is to characterize regulatory mechanisms of membrane trafficking and their role in infection and human disease. For this, we use state-of-the-art techniques, such as live-cell imaging and confocal microscopy and a broad range of molecular biology, biochemistry and cell biology methods to advance the knowledge in this area. We focus on the study of small GTPases of the Rab and Arf families of the Ras superfamily, as these have been shown to be master regulators of all steps of membrane trafficking. Mutations in several proteins of these families lead to diseases affecting mainly neurons, cilia and lysosome-related organelles. Moreover, several of these proteins have been implicated in tumorigenesis. Furthermore, Rab and Arf proteins have been shown to play essential roles in infection, since several microbes can subvert these proteins in order to escape degradation and evade the immune system. Thus, the study of the mechanisms of diseases caused by mutations in Rab and Arf proteins, as well as the subversion of these proteins by microbes can shed light on the etiology of these diseases and allow a better understanding of the protein functions.

Keywords: Molecular cell biology, ciliopathies, cell migration and adhesion, cancer, Arl, Rab, endocytic recycling traffic, lysosomes, lysosome-related organelles, regulated secretion, pigmentation, melanin, melanocyte, keratinocyte.

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Research Output at NOVA

Subversion of Ras Small GTPases in Cutaneous Melanoma Aggressiveness

Brito, C., Barral, D. C. & Pojo, M., 23 Sep 2020, In : Frontiers in Cell and Developmental Biology. 8, 575223.

Research output: Contribution to journalReview article

Open Access
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  • Open Access
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  • 1 Citation (Scopus)
    12 Downloads (Pure)

    Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling

    Casalou, C., Faustino, A., Silva, F., Ferreira, I. C., Vaqueirinho, D., Ferreira, A., Castanheira, P., Barona, T., Ramalho, J. S., Serpa, J., Félix, A. & Barral, D. C., 1 Oct 2019, In : Cancers. 11, 10, 1461.

    Research output: Contribution to journalArticle

    Open Access
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  • 3 Citations (Scopus)
    2 Downloads (Pure)

    Hyperinsulinaemia decreases insulin receptor internalisation mediated by circular dorsal ruffles

    de Oliveira, R. M., Correia, M. A., de Oliveira, L. M., Barral, D. C. & Macedo, M. P., Sep 2019, In : Diabetologia. 62, p. S103-S103

    Research output: Contribution to journalMeeting Abstract

    Melanin processing by keratinocytes: A non-microbial type of host-pathogen interaction?

    Moreiras, H., Lopes-da-Silva, M., Seabra, M. C. & Barral, D. C., 23 Apr 2019, In : Traffic. 20, 4, p. 301-304 4 p.

    Research output: Contribution to journalComment/debate

  • 2 Citations (Scopus)