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Research interests

Our long term goal is to characterize regulatory mechanisms of membrane trafficking and their role in infection and human disease. For this, we use state-of-the-art techniques, such as live-cell imaging and confocal microscopy and a broad range of molecular biology, biochemistry and cell biology methods to advance the knowledge in this area. We focus on the study of small GTPases of the Rab and Arf families of the Ras superfamily, as these have been shown to be master regulators of all steps of membrane trafficking. Mutations in several proteins of these families lead to diseases affecting mainly neurons, cilia and lysosome-related organelles. Moreover, several of these proteins have been implicated in tumorigenesis. Furthermore, Rab and Arf proteins have been shown to play essential roles in infection, since several microbes can subvert these proteins in order to escape degradation and evade the immune system. Thus, the study of the mechanisms of diseases caused by mutations in Rab and Arf proteins, as well as the subversion of these proteins by microbes can shed light on the etiology of these diseases and allow a better understanding of the protein functions.

Keywords: Molecular cell biology, ciliopathies, cell migration and adhesion, cancer, Arl, Rab, endocytic recycling traffic, lysosomes, lysosome-related organelles, regulated secretion, pigmentation, melanin, melanocyte, keratinocyte.

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CD1 Antigens Medicine & Life Sciences
Plasmodium berghei Medicine & Life Sciences
Melanocytes Medicine & Life Sciences
Melanosomes Medicine & Life Sciences
Lysosomes Medicine & Life Sciences
Proteins Medicine & Life Sciences
Melanins Medicine & Life Sciences
Antigen Presentation Medicine & Life Sciences

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Research Output at NOVA 2010 2019

1 Downloads (Pure)

Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling

Casalou, C., Faustino, A., Silva, F., Ferreira, I. C., Vaqueirinho, D., Ferreira, A., Castanheira, P., Barona, T., Ramalho, J. S., Serpa, J., Félix, A. & Barral, D. C., 1 Oct 2019, In : Cancers. 11, 10, 1461.

Research output: Contribution to journalArticle

Open Access
File
Integrins
Cell Movement
Breast Neoplasms
Neoplasms
Focal Adhesions

Hyperinsulinaemia decreases insulin receptor internalisation mediated by circular dorsal ruffles

de Oliveira, R. M., Correia, M. A., de Oliveira, L. M., Barral, D. C. & Macedo, M. P., Sep 2019, In : Diabetologia. 62, p. S103-S103

Research output: Contribution to journalMeeting Abstract

Melanin processing by keratinocytes: A non-microbial type of host-pathogen interaction?

Moreiras, H., Lopes-da-Silva, M., Seabra, M. C. & Barral, D. C., 23 Apr 2019, In : Traffic. 20, 4, p. 301-304 4 p.

Research output: Contribution to journalComment/debate

Host-Pathogen Interactions
Melanins
Pathogens
Keratinocytes
Skin Pigmentation
1 Citation (Scopus)

Rab35 controls cilium length, function and membrane composition

Kuhns, S., Seixas, C., Pestana, S., Tavares, B., Nogueira, R., Jacinto, R., Ramalho, J. S., Simpson, J. C., Andersen, J. S., Echard, A., Lopes, S. S., Barral, D. C. & Blacque, O. E., 1 Jan 2019, In : Embo Reports. e47625.

Research output: Contribution to journalArticle

Cilia
Hedgehogs
Membranes
GTP-Binding Proteins
Chemical analysis
Melanocytes
Melanins
Exocytosis
Keratinocytes
Skin Pigmentation