• Campo Mártires da Pátria, 130

    1169-056 Lisboa

    Portugal

  • 1169-05 Lisboa

    Portugal

  • 41 Citations
  • 2 h-Index
20172019
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Personal profile

Research interests

My research is focused on understanding how intracellular trafficking is important for neuronal function in aging and Alzheimer´s disease (AD). Early in AD neurons responsible for the formation of memories start to malfunction. The trigger for neuronal degeneration in AD is the toxic peptide beta-amyloid, a sticky peptide that accumulates with aging. However, in late-onset AD it is not clear whether beta-amyloid accumulation is due to increased production of the highly reactive 42 amino acid long beta-amyloid. Among the novel putative genetic risk factors for late-onset AD are regulators of endocytic trafficking. Endocytic trafficking of the amyloid precursor protein (APP) and of APP secretases, especially BACE1, are key for beta-amyloid production at endosomes. Recently, we discovered that two late-onset AD risk factors, Bin1 and CD2AP, loss of function deregulate the endocytic trafficking in neurons of amyloid precursor protein and its first cleavage enzyme (BACE1), leading to increased beta-amyloid production.

Now we are investigating the impact of AD variants in Bin1 and CD2AP function. We are investigating neuronal aging because old age is the most important risk factor for late-onset AD. In the lab, we discovered neuronal aging alterations in endocytosis, and are working to determine its impact into aging-synaptic decline. We use unique aging cellular systems with comprehensive advanced quantitative dynamic imaging, proteomics, and neurosciences.

Keywords: Neuroscience, Cell biology, Alzheimer's disease, Intracellular trafficking

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  • 5 Similar Profiles
Amyloid Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Amyloid Precursor Protein Secretases Medicine & Life Sciences
Neurons Medicine & Life Sciences
Endosomes Medicine & Life Sciences
Serum Amyloid A Protein Medicine & Life Sciences
Multivesicular Bodies Medicine & Life Sciences

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Research Output at NOVA 2017 2019

  • 41 Citations
  • 2 h-Index
  • 3 Meeting Abstract
  • 3 Article

EHD proteins mediate ubiquitin-dependent recycling of gap junctions (GJs) in the ischemic heart

Marques, T. M., Catarino, S., Almeida, C. G. & Girao, H., Apr 2019, In : European Journal Of Clinical Investigation. 49, p. 29-29

Research output: Contribution to journalMeeting Abstract

EHD proteins mediate gap junction (GJ) remodeling during myocardial ischemia

Martins-Marques, T., Catarino, S., Almeida, C. G. & Girao, H., Aug 2018, In : European Heart Journal. 39, p. 454-454

Research output: Contribution to journalMeeting Abstract

7 Citations (Scopus)

Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production

Guimas Almeida, C., Sadat Mirfakhar, F., Perdigão, C. & Burrinha, T., Jul 2018, In : Cellular and Molecular Life Sciences. 75, 14, p. 2577-2589 13 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Genome-Wide Association Study

The Endolysosomal System and Proteostasis: From Development to Degeneration

Winckler, B., Faundez, V., Maday, S., Cai, Q., Almeida, C. G. & Zhang, H., 31 Oct 2018, In : Journal Of Neuroscience Methods. 38, 44, p. 9364-9374

Research output: Contribution to journalArticle

Actin control of endosomal sorting in neurons: impact on Alzheimer's disease.

Guimas Almeida, C., Salavessa, L. & Oliveira, L., 2017, In : Molecular Biology of the Cell. 28

Research output: Contribution to journalMeeting Abstract

Press / Media