Photo of Claudia Guimas Almeida
  • Campo Mártires da Pátria, 130

    1169-056 Lisboa

    Portugal

  • 1169-05 Lisboa

    Portugal

Accepting PhD Students

  • 1933 Citations
  • 8 h-Index
20172020

Research output per year

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Personal profile

Research interests

My research is focused on understanding how intracellular trafficking is important for neuronal function in aging and Alzheimer´s disease (AD). Early in AD neurons responsible for the formation of memories start to malfunction. The trigger for neuronal degeneration in AD is the toxic peptide beta-amyloid, a sticky peptide that accumulates with aging. However, in late-onset AD it is not clear whether beta-amyloid accumulation is due to increased production of the highly reactive 42 amino acid long beta-amyloid. Among the novel putative genetic risk factors for late-onset AD are regulators of endocytic trafficking. Endocytic trafficking of the amyloid precursor protein (APP) and of APP secretases, especially BACE1, are key for beta-amyloid production at endosomes. Recently, we discovered that two late-onset AD risk factors, Bin1 and CD2AP, loss of function deregulate the endocytic trafficking in neurons of amyloid precursor protein and its first cleavage enzyme (BACE1), leading to increased beta-amyloid production.

Now we are investigating the impact of AD variants in Bin1 and CD2AP function. We are investigating neuronal aging because old age is the most important risk factor for late-onset AD. In the lab, we discovered neuronal aging alterations in endocytosis, and are working to determine its impact into aging-synaptic decline. We use unique aging cellular systems with comprehensive advanced quantitative dynamic imaging, proteomics, and neurosciences.

Keywords: Neuroscience, Cell biology, Alzheimer's disease, Intracellular trafficking

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Research Output at NOVA

  • 1933 Citations
  • 8 h-Index
  • 6 Article
  • 3 Meeting Abstract
  • 1 Review article
  • 1 Other contribution
Open Access
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  • EHD proteins mediate ubiquitin-dependent recycling of gap junctions (GJs) in the ischemic heart

    Marques, T. M., Catarino, S., Almeida, C. G. & Girao, H., Apr 2019, In : European Journal Of Clinical Investigation. 49, p. 29-29

    Research output: Contribution to journalMeeting Abstract

    Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis

    Burrinha, T., Gomes, R., Terrasso, A. P. & Almeida, C. G., 23 Apr 2019

    Research output: Other contribution

    EHD proteins mediate gap junction (GJ) remodeling during myocardial ischemia

    Martins-Marques, T., Catarino, S., Almeida, C. G. & Girao, H., Aug 2018, In : European Heart Journal. 39, p. 454-454

    Research output: Contribution to journalMeeting Abstract

  • 9 Citations (Scopus)

    Press / Media