Research Output per year
Research Output at NOVA
2020
Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials
Raimundo, A. F., Félix, F., Andrade, R., García-Conesa, M. T., González-Sarrías, A., Gilsa-Lopes, J., do Ó, D., Raimundo, A., Ribeiro, R., Rodriguez-Mateos, A., Santos, C. N., Schär, M., Silva, A., Cruz, I., Wang, B., Pinto, P. & Menezes, R., 2020, In : European Journal of Nutrition.Research output: Contribution to journal › Review article
1
Citation
(Scopus)
Flavonoids as potential drugs for VPS13-dependent rare neurodegenerative diseases
Soczewka, P., Flis, K., Tribouillard-Tanvier, D., Di Rago, J. P., Santos, C. N., Menezes, R., Kaminska, J. & Zoladek, T., Jul 2020, In : Genes. 11, 7, p. 1-17 17 p., 828.Research output: Contribution to journal › Article
Open Access
Natural Products: Optimizing Cancer Treatment through Modulation of Redox Balance
Rijo, P., Pešić, M., Fernandes, A. S. & Santos, C. N., 2020, In : Oxidative Medicine and Cellular Longevity. 2020, 2407074.Research output: Contribution to journal › Review article
Open Access
File
Second Food Bioactives and Health Conference
Dos Santos, C. N., 19 Feb 2020, In : Journal of Agricultural and Food Chemistry. 68, 7, p. 1761-1762 2 p.Research output: Contribution to journal › Editorial
2019
5-(Hydroxyphenyl)-γ-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: Evidence from different in silico, in vitro and in vivo experimental models
Angelino, D., Carregosa, D., Domenech-Coca, C., Savi, M., Figueira, I., Brindani, N., Jang, S., Lakshman, S., Molokin, A., Urban, J. F., Davis, C. D., Brito, M. A., Kim, K. S., Brighenti, F., Curti, C., Bladé, C., Del Bas, J. M., Stilli, D., Solano-Aguilar, G. I., Dos Santos, C. N. & 2 others, , 1 Nov 2019, In : Nutrients. 11, 11, 2678.Research output: Contribution to journal › Article
Open Access
File
8
Citations
(Scopus)
2
Downloads
(Pure)
Berry-enriched diet in salt-sensitive hypertensive rats: Metabolic fate of (poly)phenols and the role of gut microbiota
Gomes, A., Oudot, C., Macià, A., Foito, A., Carregosa, D., Stewart, D., Van de Wiele, T., Berry, D., Motilva, M. J., Brenner, C. & Dos Santos, C. N., 1 Nov 2019, In : Nutrients. 11, 11, 2634.Research output: Contribution to journal › Article
Open Access
4
Citations
(Scopus)
Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study
Figueira, I., Tavares, L., Jardim, C., Costa, I., Terrasso, A. P., Almeida, A. F., Govers, C., Mes, J. J., Gardner, R., Becker, J. D., McDougall, G. J., Stewart, D., Filipe, A., Kim, K. S., Brites, D., Brito, C., Brito, M. A. & Santos, C. N., 1 Feb 2019, In : European Journal of Nutrition. 58, 1, p. 113-130 18 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Carbon monoxide released by CORM-A1 prevents yeast cell death via autophagy stimulation
Figueiredo-Pereira, C., Menezes, R., Ferreira, S., Santos, C. N. & Vieira, H. L. A., 1 Aug 2019, In : Fems Yeast Research. 19, 5Research output: Contribution to journal › Article
2
Citations
(Scopus)
CSRP3 mediates polyphenols-induced cardioprotection in hypertension
Oudot, C., Gomes, A., Nicolas, V., Le Gall, M., Chaffey, P., Broussard, C., Calamita, G., Mastrodonato, M., Gena, P., Perfettini, J. L., Hamelin, J., Lemoine, A., Fischmeister, R., Vieira, H. L. A., Santos, C. N. & Brenner, C., 1 Apr 2019, In : Journal of Nutritional Biochemistry. 66, p. 29-42 14 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism
De Bruyne, T., Steenput, B., Roth, L., De Meyer, G. R. Y., Santos, C. N. D., Valentová, K., Dambrova, M. & Hermans, N., 8 Mar 2019, In : Nutrients. 11, 3Research output: Contribution to journal › Review article
Open Access
File
8
Citations
(Scopus)
20
Downloads
(Pure)
Identification and microbial production of the raspberry phenol salidroside that is active against huntington’s disease
Kallscheuer, N., Menezes, R., Foito, A., Da Silva, M. H., Braga, A., Dekker, W., Sevillano, D. M., Rosado-Ramos, R., Jardim, C., Oliveira, J., Ferreira, P., Rocha, I., Silva, A. R., Sousa, M., Allwood, J. W., Bott, M., Faria, N., Stewart, D., Ottens, M., Naesby, M. & 2 others, , 1 Mar 2019, In : Plant Physiology. 179, 3, p. 969-985 17 p.Research output: Contribution to journal › Article
10
Citations
(Scopus)
INFOGEST static in vitro simulation of gastrointestinal food digestion
Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., Clemente, A., Corredig, M., Dupont, D., Dufour, C., Edwards, C., Golding, M., Karakaya, S., Kirkhus, B., Le Feunteun, S., Lesmes, U. & 15 others, , 1 Apr 2019, In : Nature Protocols. 14, 4, p. 991-1014 24 p.Research output: Contribution to journal › Article
Open Access
123
Citations
(Scopus)
Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation
Carregosa, D., Carecho, R., Figueira, I. & Santos, C. N., 19 Feb 2019, In : Journal of Agricultural and Food Chemistry. 68, 7, p. 1790-1807Research output: Contribution to journal › Review article
5
Citations
(Scopus)
Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)
Tur, J. A., Jacob, C., Chaimbault, P., Tadayyon, M., Richling, E., Hermans, N., Nunes dos Santos, C., Diederich, M., Giblin, L., Elhabiri, M., Gaucher, C., Andreoletti, P., Fernandes, A., Davies, M., Bartoszek, A. & Cherkaoui-Malki, M., 1 Jan 2019, In : Free Radical Research.Research output: Contribution to journal › Comment/debate
Open Access
2
Citations
(Scopus)
Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol
Dias-Pedroso, D., Guerra, J., Gomes, A., Oudot, C., Brenner, C., Santos, C. N. & Vieira, H. L. A., Apr 2019, In : Cardiovascular Toxicology. 19, 2, p. 156-167 11 p.Research output: Contribution to journal › Article
RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild and cultivated berry fruit species with high content of phenolics
Thole, V., Bassard, J. E., Ramírez-González, R., Trick, M., Ghasemi Afshar, B., Breitel, D., Hill, L., Foito, A., Shepherd, L., Freitag, S., Nunes Dos Santos, C., Menezes, R., Banãdos, P., Naesby, M., Wang, L., Sorokin, A., Tikhonova, O., Shelenga, T., Stewart, D., Vain, P. & 1 others, , 19 Dec 2019, In : BMC Genomics. 20, 1, 995.Research output: Contribution to journal › Article
Open Access
File
3
Citations
(Scopus)
3
Downloads
(Pure)
The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism
Ferreira, C., Couceiro, J., Família, C., Jardim, C., Antas, P., Santos, C. N., Outeiro, T. F., Tenreiro, S. & Quintas, A., 8 Aug 2019, In : Fems Yeast Research. 19, 5, foz042.Research output: Contribution to journal › Article
1
Citation
(Scopus)
2018
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis
Macedo, D., Jardim, C., Figueira, I., Almeida, A. F., McDougall, G. J., Stewart, D., Yuste, J. E., Tomás-Barberán, F. A., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 3 May 2018, In : Scientific Reports. 8, 1, 6965.Research output: Contribution to journal › Article
Open Access
File
3
Citations
(Scopus)
21
Downloads
(Pure)
BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits
Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., Bassard, J. E., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., Fernandes, A. & 63 others, , 1 Apr 2018, In : Phytochemistry Reviews. 17, 2, p. 291-326 36 p.Research output: Contribution to journal › Review article
11
Citations
(Scopus)
Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation
Almeida, A. F., Borge, G. I. A., Piskula, M., Tudose, A., Tudoreanu, L., Valentová, K., Williamson, G. & Santos, C. N., 1 May 2018, In : Comprehensive Reviews in Food Science and Food Safety. 17, 3, p. 714-731 18 p.Research output: Contribution to journal › Article
35
Citations
(Scopus)
Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells
Lopez de las Hazas, M-C., Godinho-Pereira, J., Macia, A., Filipa Almeida, A., Rita Ventura, M., Motilva, M-J. & Santos, C. N., Jul 2018, In : Journal of Functional Foods. 46, p. 110-117Research output: Contribution to journal › Article
14
Citations
(Scopus)
Polyphenols as new leads in drug discovery: Biological activity and mechanisms
dos Santos, C. N., Menezes, R. & Stewart, D., 1 Jan 2018, In : Current Pharmaceutical Design. 24, 19, p. 2041-2042 2 p.Research output: Contribution to journal › Editorial
1
Citation
(Scopus)
Pure polyphenols applications for cardiac health and disease
Santos, C. N., Gomes, A., Oudot, C., Dias-Pedroso, D., Rodriguez-Mateos, A., Vieira, H. L. A. & Brenner, C., 2018, In : Current Pharmaceutical Design. 24, 19, p. 2137 - 2156Research output: Contribution to journal › Article
4
Citations
(Scopus)
2017
(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways
Jardim, C., Macedo, D., Figueira, I., Dobson, G., McDougall, G. J., Stewart, D., Ferreira, R. B., Menezes, R. & Santos, C. N., 1 May 2017, In : Journal of Functional Foods. 32, p. 333-346 14 p.Research output: Contribution to journal › Article
7
Citations
(Scopus)
Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation
Garcia, G., Nanni, S., Figueira, I., Ivanov, I., McDougall, G. J., Stewart, D., Ferreira, R. B., Pinto, P., Silva, R. F. M., Brites, D. & Santos, C. N., 15 Jan 2017, In : Food Chemistry. 215, p. 274-283 10 p.Research output: Contribution to journal › Article
25
Citations
(Scopus)
Dairy products and inflammation: A review of the clinical evidence
Bordoni, A., Danesi, F., Dardevet, D., Dupont, D., Fernandez, A. S., Gille, D., Nunes dos Santos, C., Pinto, P., Re, R., Rémond, D., Shahar, D. R. & Vergères, G., 13 Aug 2017, In : Critical Reviews in Food Science and Nutrition. 57, 12, p. 2497-2525 29 p.Research output: Contribution to journal › Review article
62
Citations
(Scopus)
Exploring the power of yeast to model aging and age-related neurodegenerative disorders
Oliveira, A. V., Vila�a, R., Santos, C. N., Costa, V. & Menezes, R., 1 Feb 2017, In : Biogerontology. 18, 1, p. 3-34 32 p.Research output: Contribution to journal › Review article
19
Citations
(Scopus)
Phycocyanin protects against Alpha-Synuclein toxicity in yeast
Macedo, D., Bertolin, T. E., Oro, T., Backes, L. T. H., Brás, I. C., Santos, C. N., Tenreiro, S. & Outeiro, T. F., 2017, In : Journal of Functional Foods. 38, p. 553-560 8 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Polyphenols beyond barriers: A glimpse into the brain
Figueira, I., Menezes, R., Macedo, D., Costa, I. & dos Santos, C. N., 1 May 2017, In : Current Neuropharmacology. 15, 4, p. 562-594 33 p.Research output: Contribution to journal › Review article
40
Citations
(Scopus)
Polyphenols journey through blood-brain barrier towards neuronal protection
Figueira, I., Garcia, G., Pimpão, R. C., Terrasso, A. P., Costa, I., Almeida, A. F., Tavares, L., Pais, T. F., Ventura, M. R., Filipe, A., McDougall, G. J., Stewart, D., Kim, K. S., Palmela, I., Brites, D., Brito, M. A., Santos, C. N. & Brito, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 11456.Research output: Contribution to journal › Article
47
Citations
(Scopus)
Synthesis of New Sulfated and Glucuronated Metabolites of Dietary Phenolic Compounds Identified in Human Biological Samples
Almeida, A. F., Santos, C. N. & Ventura, M. R., 9 Aug 2017, In : Journal of Agricultural and Food Chemistry. 65, 31, p. 6460-6466 7 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Worldwide (poly)phenol intake: assessment methods and identified gaps
Pinto, P. & Santos, C. N., 1 Jun 2017, In : European Journal of Nutrition. 56, 4, p. 1393-1408 16 p.Research output: Contribution to journal › Review article
23
Citations
(Scopus)
2016
Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study
Rodriguez-Mateos, A., Feliciano, R. P., Boeres, A., Weber, T., Santos, M. C., Lima, M. R. & Heiss, C., 1 Oct 2016, In : Molecular Nutrition & Food Research. 60, 10, p. 2130-2140 11 p.Research output: Contribution to journal › Article
42
Citations
(Scopus)
High-throughput yeast-based reporter assay to identify compounds with anti-inflammatory potential
Garcia, G., do Santos, C. N. & Menezes, R., 1 Sep 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1449. p. 441-452 12 p. (Methods in Molecular Biology; vol. 1449).Research output: Chapter in Book/Report/Conference proceeding › Chapter
1
Citation
(Scopus)
Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols
Feliciano, R. P., Boeres, A., Massacessi, L., Istas, G., Lima, M. R., Nunes Dos Santos, C., Heiss, C. & Rodriguez-Mateos, A., 1 Jun 2016, In : Archives of Biochemistry and Biophysics. 599, p. 31-41 11 p.Research output: Contribution to journal › Article
65
Citations
(Scopus)
Protective Effect of a (Poly)phenol-Rich Extract Derived from Sweet Cherries Culls against Oxidative Cell Damage
Matias, A. A., Rosado-Ramos, R., Nunes, S. L., Figueira, I., Serra, A. T., Bronze, M. R., Santos, C. N. & Duarte, C. M. M., 1 Apr 2016, In : Molecules (Basel, Switzerland). 21, 4, 406.Research output: Contribution to journal › Article
18
Citations
(Scopus)
The harmonized INFOGEST in vitro digestion method: From knowledge to action
Egger, L., Ménard, O., Delgado-Andrade, C., Alvito, P., Assunção, R., Balance, S., Barberá, R., Brodkorb, A., Cattenoz, T., Clemente, A., Comi, I., Dupont, D., Garcia-Llatas, G., Lagarda, M. J., Le Feunteun, S., JanssenDuijghuijsen, L., Karakaya, S., Lesmes, U., Mackie, A. R., Martins, C. & 18 others, , 1 Oct 2016, In : Food Research International. 88, p. 217-225 9 p.Research output: Contribution to journal › Article
75
Citations
(Scopus)
2015
(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy
Macedo, D., Tavares, L., McDougall, G. J., Vicente Miranda, H., Stewart, D., Boavida, R., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 2015, In : Human molecular genetics. 24, 6, p. 1717-1732 16 p., ddu585.Research output: Contribution to journal › Article
39
Citations
(Scopus)
Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation
Gomes, A., Pimpão, R. C., Fortalezas, S., Figueira, I., Miguel, C., Aguiar, C., Salgueiro, L., Cavaleiro, C., Gonçalves, M. J., Clemente, A., Costa, C., Martins-Loução, M. A., Boavida, R. & Santos, C. N., 5 Nov 2015, In : Industrial Crops and Products. 74, p. 505-513 9 p.Research output: Contribution to journal › Article
9
Citations
(Scopus)
From the baker to the bedside: yeast models of Parkinson's disease
Menezes, R., Macedo, D. L. C., Santos, M. C., Tenreiro, S. & Outeiro, T. F., Aug 2015, In : Microbial Cell. 2, 8, p. 262-279 18 p.Research output: Contribution to journal › Review article
Open Access
File
36
Citations
(Scopus)
19
Downloads
(Pure)
Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols
Bohn, T., Mcdougall, G. J., Alegría, A., Alminger, M., Arrigoni, E., Aura, A. M., Brito, C., Cilla, A., El, S. N., Karakaya, S., Martínez-Cuesta, M. C. & Santos, C. N., 1 Jul 2015, In : Molecular Nutrition & Food Research. 59, 7, p. 1307-1323 17 p.Research output: Contribution to journal › Review article
107
Citations
(Scopus)
Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée
Pimpão, R. C., Lima, M. R., Boavida, R., Williamson, G. & Santos, C. N., 14 Feb 2015, In : British Journal Of Nutrition. 113, 3, p. 454-463 10 p.Research output: Contribution to journal › Article
61
Citations
(Scopus)
Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
Rémond, D., Shahar, D. R., Gille, D., Pinto, P., Kachal, J., Peyron, M. A., Santos, M. C., Walther, B., Bordoni, A., Dupont, D., Tomás-Cobos, L. & Vergères, G., 2015, In : Oncotarget. 6, 16, p. 13858-13898 41 p.Research output: Contribution to journal › Article
51
Citations
(Scopus)
2014
A standardised static in vitro digestion method suitable for food-an international consensus
Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., Dufour, C., Egger, L., Golding, M., Karakaya, S., Kirkhus, B., Le Feunteun, S., Lesmes, U., MacIerzanka, A., MacKie, A., Marze, S. & 9 others, , 2014, In : Food and Function. 5, 6, p. 1113-1124 12 p.Research output: Contribution to journal › Article
1424
Citations
(Scopus)
In vitro models for studying secondary plant metabolite digestion and bioaccessibility
Alminger, M., Aura, A. M., Bohn, T., Dufour, C., El, S. N., Gomes, A., Karakaya, S., Martínez-Cuesta, M. C., Mcdougall, G. J., Requena, T. & Santos, C. N., 2014, In : Comprehensive Reviews in Food Science and Food Safety. 13, 4, p. 413-436 24 p.Research output: Contribution to journal › Review article
137
Citations
(Scopus)
Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
Tenreiro, S., Reimão-Pinto, M. M., Antas, P., Rino, J., Wawrzycka, D., Macedo, D., Rosado-Ramos, R., Amen, T., Waiss, M., Magalhães, F., Gomes, A., Santos, C. N., Kaganovich, D. & Outeiro, T. F., 2014, In : PLoS Genetics. 10, 5, e1004302.Research output: Contribution to journal › Article
80
Citations
(Scopus)
Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers
Pimpão, R. C., Dew, T., Figueira, M. E., Mcdougall, G. J., Stewart, D., Ferreira, R. B., Santos, C. N. & Williamson, G., 2014, In : Molecular Nutrition & Food Research. 58, 7, p. 1414-1425 12 p.Research output: Contribution to journal › Article
47
Citations
(Scopus)
Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae
Pimentel, C., Caetano, S. M., Menezes, R., Figueira, I., Santos, C. N., Ferreira, R. B., Santos, M. A. S. & Pousada, C. A., 2014, In : Biochimica Et Biophysica Acta-General Subjects. 1840, 6, p. 1977-1986 10 p.Research output: Contribution to journal › Article
18
Citations
(Scopus)
2013
Analysis of Phenolic Compounds in Portuguese Wild and Commercial Berries after Multienzyme Hydrolysis
Santos, M. C., 1 Jan 2013, In : Journal of Agricultural and Food Chemistry. 61, 17, p. 4053-4062Research output: Contribution to journal › Article
Open Access
28
Citations
(Scopus)
beta-N-Acetylhexosaminidase involvement in alpha-conglutin mobilization in Lupinus albus
Santos, M. C., 1 Jan 2013, In : Journal Of Plant Physiology. 170, 12, p. 1047-1056Research output: Contribution to journal › Article
Open Access
3
Citations
(Scopus)