Cláudia Nunes dos Santos

Häkkinen, S. T., Soković, M., Nohynek, L., Ćirić, A., Ivanov, M., Stojković, D., Tsitko, I., Matos, M., Baixinho, J. P., Ivasiv, V., Fernández, N., Dos Santos, C. N. & Oksman-Caldentey, K. M., Sep 2021, In: Pharmaceuticals. 14, 9, 941.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Correction to: Polyphenols journey through blood-brain barrier towards neuronal protection (Scientific Reports, (2017), 7, 1, (11456), 10.1038/s41598-017-11512-6)

Figueira, I., Garcia, G., Pimpão, R. C., Terrasso, A. P., Costa, I., Almeida, A. F., Tavares, L., Pais, T. F., Pinto, P., Ventura, M. R., Filipe, A., McDougall, G. J., Stewart, D., Kim, K. S., Palmela, I., Brites, D., Brito, M. A., Brito, C. & Santos, C. N., Dec 2021, In: Scientific Reports. 11, 1, 17112.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey

Carecho, R., Carregosa, D. & Dos Santos, C. N., 9 Feb 2021, In: Brain plasticity (Amsterdam, Netherlands). 6, 2, p. 193-214 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

178 Downloads (Pure)

Overview of beneficial effects of (Poly)phenol metabolites in the context of neurodegenerative diseases on model organisms

Carregosa, D., Mota, S., Ferreira, S., Alves-Dias, B., Loncarevic-Vasiljkovic, N., Crespo, C. L., Menezes, R., Teodoro, R. & Santos, C. N. D., Sep 2021, In: Nutrients. 13, 9, 2940.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

11 Citations (Scopus)

3 Downloads (Pure)

Polyphenol metabolite pyrogallol-o-sulfate decreases microglial activation and vegf in retinal pigment epithelium cells and diabetic mouse retina

Santos, D. F., Pais, M., Santos, C. N. & Silva, G. A., 1 Nov 2021, In: International Journal of Molecular Sciences. 22, 21, 11402.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

10 Downloads (Pure)

Sesquiterpene lactones: Promising natural compounds to fight inflammation

Matos, M. S., Anastácio, J. D. & Dos Santos, C. N., Jul 2021, In: Pharmaceutics. 13, 7, 991.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Citations (Scopus)

Small molecule fisetin modulates alpha-Synuclein aggregation

Rosado-Ramos, R., Godinho-Pereira, J., Marques, D., Figueira, I., Outeiro, T. F., Menezes, R. & Dos Santos, C. N., 1 Jun 2021, In: Molecules. 26, 11, 3353.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

4 Downloads (Pure)

Supercritical CO₂ Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots

Baixinho, J. P., Anastácio, J. D., Ivasiv, V., Cankar, K., Bosch, D., Menezes, R., de Roode, M., Santos, C. N. D., Matias, A. A. & Fernández, N., 28 Apr 2021, In: Molecules. 26, 9, 2583.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Citations (Scopus)

2 Downloads (Pure)

Urolithin B protects pancreatic beta cells against IAPP proteotoxicity: a potential strategy for dietary interventions in diabetes

Raimundo, A. F., Ferreira, S., Brito, J., Silva, M., Dos Santos, C. N. & Menezes, R., Sep 2021, In: Diabetologia. 64, SUPPL 1, p. 197-197

Research output: Contribution to journal › Meeting Abstract › peer-review

Urolithins: Diet-derived bioavailable metabolites to tackle diabetes

Raimundo, A. F., Ferreira, S., Tomás-Barberán, F. A., Santos, C. N. & Menezes, R., Dec 2021, In: Nutrients. 13, 12, 4285.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

8 Citations (Scopus)

31 Downloads (Pure)

2020

Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory

Matos, M. S., Anastácio, J. D., Allwood, J. W., Carregosa, D., Marques, D., Sungurtas, J., McDougall, G. J., Menezes, R., Matias, A. A., Stewart, D. & Dos Santos, C. N., Nov 2020, In: Nutrients. 12, 11, p. 1-20 20 p., 3547.

Research output: Contribution to journal › Article › peer-review

Open Access

File

11 Citations (Scopus)

17 Downloads (Pure)

Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats

Gomes, A., Godinho-Pereira, J., Oudot, C., Sequeira, C. O., Macià, A., Carvalho, F., Motilva, M. J., Pereira, S. A., Matzapetakis, M., Brenner, C. & Santos, C. N., Jul 2020, In: Free Radical Biology And Medicine. 154, p. 119-131 13 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties

Garcia, G., Pais, T. F., Pinto, P., Dobson, G., McDougall, G. J., Stewart, D. & Santos, C. N., Oct 2020, In: Antioxidants. 9, 10, p. 1-20 20 p., 970.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Menezes, R., Foito, A., Jardim, C., Costa, I., Garcia, G., Rosado-Ramos, R., Freitag, S., Alexander, C. J., Outeiro, T. F., Stewart, D. & Santos, C. N., Sep 2020, In: Antioxidants. 9, 9, 789.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

21 Downloads (Pure)

Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials

Raimundo, A. F., Félix, F., Andrade, R., García-Conesa, M. T., González-Sarrías, A., Gilsa-Lopes, J., do Ó, D., Raimundo, A., Ribeiro, R., Rodriguez-Mateos, A., Santos, C. N., Schär, M., Silva, A., Cruz, I., Wang, B., Pinto, P. & Menezes, R., Jun 2020, In: European Journal of Nutrition. 59, 4, p. 1329-1343

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Flavonoids as potential drugs for VPS13-dependent rare neurodegenerative diseases

Soczewka, P., Flis, K., Tribouillard-Tanvier, D., Di Rago, J. P., Santos, C. N., Menezes, R., Kaminska, J. & Zoladek, T., Jul 2020, In: Genes. 11, 7, p. 1-17 17 p., 828.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

Flavonols and Flavones

Dos Santos, C. N., Menezes, R., Carregosa, D., Valentova, K., Foito, A., Mcdougall, G. & Stewart, D., 23 Oct 2020, Dietary Polyphenols: Their Metabolism and Health Effects. Tomás‐Barberán, F. A., González‐Sarrías, A. & García‐Villalba, R. (eds.). Wiley, p. 163-198

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Raimundo, A. F., Ferreira, S., Farrim, M. I., Santos, C. N. & Menezes, R., 3 Sep 2020, In: Frontiers in Microbiology. 11, 2035.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

6 Downloads (Pure)

Low molecular weight gut polyphenols metabolites and its nutritional relevance as effectors for attenuating neuroinflammation

Carregosa, D., Carecho, R., Figueira, I. & dos Santos, C. N., 2020, In: Proceedings of the Nutrition Society. 79, OCE2, p. E287-E287

Research output: Contribution to journal › Meeting Abstract › peer-review

Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal

Portuguese network for SARS-CoV-2 genomics, Dec 2020, In: Emerging Microbes and Infections. 9, 1, p. 2488-2496 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

13 Citations (Scopus)

93 Downloads (Pure)

Natural Products: Optimizing Cancer Treatment through Modulation of Redox Balance

Rijo, P., Pešić, M., Fernandes, A. S. & Santos, C. N., 3 Jun 2020, In: Oxidative Medicine and Cellular Longevity. 2020, 2407074.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

3 Citations (Scopus)

3 Downloads (Pure)

Second Food Bioactives and Health Conference

Dos Santos, C. N., 19 Feb 2020, In: Journal of Agricultural and Food Chemistry. 68, 7, p. 1761-1762 2 p.

Research output: Contribution to journal › Editorial › peer-review

Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease

Ruskovska, T., Massaro, M., Carluccio, M. A., Arola-Arnal, A., Muguerza, B., Vanden Berghe, W., Declerck, K., Bravo, F. I., Calabriso, N., Combet, E., Gibney, E. R., Gomes, A., Gonthier, M. P., Kistanova, E., Krga, I., Mena, P., Morand, C., Nunes Dos Santos, C., De Pascual-Teresa, S., Rodriguez-Mateos, A., & 3 othersScoditti, E., Suárez, M. & Milenkovic, D., Jun 2020, In: Food and Function. 11, 6, p. 5040-5064 25 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

2019

5-(Hydroxyphenyl)-γ-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: Evidence from different in silico, in vitro and in vivo experimental models

Angelino, D., Carregosa, D., Domenech-Coca, C., Savi, M., Figueira, I., Brindani, N., Jang, S., Lakshman, S., Molokin, A., Urban, J. F., Davis, C. D., Brito, M. A., Kim, K. S., Brighenti, F., Curti, C., Bladé, C., Del Bas, J. M., Stilli, D., Solano-Aguilar, G. I., Dos Santos, C. N., & 2 othersDel Rio, D. & Mena, P., 1 Nov 2019, In: Nutrients. 11, 11, 2678.

Research output: Contribution to journal › Article › peer-review

Open Access

File

39 Citations (Scopus)

16 Downloads (Pure)

Berry-enriched diet in salt-sensitive hypertensive rats: Metabolic fate of (poly)phenols and the role of gut microbiota

Gomes, A., Oudot, C., Macià, A., Foito, A., Carregosa, D., Stewart, D., Van de Wiele, T., Berry, D., Motilva, M. J., Brenner, C. & Dos Santos, C. N., 1 Nov 2019, In: Nutrients. 11, 11, 2634.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Figueira, I., Tavares, L., Jardim, C., Costa, I., Terrasso, A. P., Almeida, A. F., Govers, C., Mes, J. J., Gardner, R., Becker, J. D., McDougall, G. J., Stewart, D., Filipe, A., Kim, K. S., Brites, D., Brito, C., Brito, M. A. & Santos, C. N., 1 Feb 2019, In: European Journal of Nutrition. 58, 1, p. 113-130 18 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Carbon monoxide released by CORM-A1 prevents yeast cell death via autophagy stimulation

Figueiredo-Pereira, C., Menezes, R., Ferreira, S., Santos, C. N. & Vieira, H. L. A., 1 Aug 2019, In: FEMS Yeast Research. 19, 5, foz051.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

CSRP3 mediates polyphenols-induced cardioprotection in hypertension

Oudot, C., Gomes, A., Nicolas, V., Le Gall, M., Chaffey, P., Broussard, C., Calamita, G., Mastrodonato, M., Gena, P., Perfettini, J. L., Hamelin, J., Lemoine, A., Fischmeister, R., Vieira, H. L. A., Santos, C. N. & Brenner, C., 1 Apr 2019, In: Journal of Nutritional Biochemistry. 66, p. 29-42 14 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism

De Bruyne, T., Steenput, B., Roth, L., De Meyer, G. R. Y., Santos, C. N. D., Valentová, K., Dambrova, M. & Hermans, N., 8 Mar 2019, In: Nutrients. 11, 3, 578.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

29 Citations (Scopus)

46 Downloads (Pure)

Identification and microbial production of the raspberry phenol salidroside that is active against huntington’s disease

Kallscheuer, N., Menezes, R., Foito, A., Da Silva, M. H., Braga, A., Dekker, W., Sevillano, D. M., Rosado-Ramos, R., Jardim, C., Oliveira, J., Ferreira, P., Rocha, I., Silva, A. R., Sousa, M., Allwood, J. W., Bott, M., Faria, N., Stewart, D., Ottens, M., Naesby, M., & 2 othersDos Santos, C. N. & Marienhagen, J., 1 Mar 2019, In: Plant Physiology. 179, 3, p. 969-985 17 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

INFOGEST static in vitro simulation of gastrointestinal food digestion

Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., Clemente, A., Corredig, M., Dupont, D., Dufour, C., Edwards, C., Golding, M., Karakaya, S., Kirkhus, B., Le Feunteun, S., Lesmes, U., & 15 othersMacierzanka, A., Mackie, A. R., Martins, C., Marze, S., McClements, D. J., Ménard, O., Minekus, M., Portmann, R., Santos, C. N., Souchon, I., Singh, R. P., Vegarud, G. E., Wickham, M. S. J., Weitschies, W. & Recio, I., 1 Apr 2019, In: Nature Protocols. 14, 4, p. 991-1014 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

985 Citations (Scopus)

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Carregosa, D., Carecho, R., Figueira, I. & Santos, C. N., 19 Feb 2019, In: Journal of Agricultural and Food Chemistry. 68, 7, p. 1790-1807

Research output: Contribution to journal › Review article › peer-review

Open Access

File

39 Citations (Scopus)

3 Downloads (Pure)

Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)

Tur, J. A., Jacob, C., Chaimbault, P., Tadayyon, M., Richling, E., Hermans, N., Nunes dos Santos, C., Diederich, M., Giblin, L., Elhabiri, M., Gaucher, C., Andreoletti, P., Fernandes, A., Davies, M., Bartoszek, A. & Cherkaoui-Malki, M., 1 Jan 2019, In: Free Radical Research.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

File

2 Citations (Scopus)

Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol

Dias-Pedroso, D., Guerra, J., Gomes, A., Oudot, C., Brenner, C., Santos, C. N. & Vieira, H. L. A., Apr 2019, In: Cardiovascular Toxicology. 19, 2, p. 156-167 11 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild and cultivated berry fruit species with high content of phenolics

Thole, V., Bassard, J. E., Ramírez-González, R., Trick, M., Ghasemi Afshar, B., Breitel, D., Hill, L., Foito, A., Shepherd, L., Freitag, S., Nunes Dos Santos, C., Menezes, R., Banãdos, P., Naesby, M., Wang, L., Sorokin, A., Tikhonova, O., Shelenga, T., Stewart, D., Vain, P., & 1 othersMartin, C., 19 Dec 2019, In: BMC Genomics. 20, 1, 995.

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Citations (Scopus)

20 Downloads (Pure)

The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism

Ferreira, C., Couceiro, J., Família, C., Jardim, C., Antas, P., Santos, C. N., Outeiro, T. F., Tenreiro, S. & Quintas, A., 8 Aug 2019, In: FEMS Yeast Research. 19, 5, foz042.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2018

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

Macedo, D., Jardim, C., Figueira, I., Almeida, A. F., McDougall, G. J., Stewart, D., Yuste, J. E., Tomás-Barberán, F. A., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 3 May 2018, In: Scientific Reports. 8, 1, 6965.

Research output: Contribution to journal › Article › peer-review

Open Access

File

14 Citations (Scopus)

29 Downloads (Pure)

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., Bassard, J. E., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., Fernandes, A., & 63 othersFerreira, P., Ferro, R., Foito, A., Freitag, S., Garcia, G., Gaspar, P., Godinho-Pereira, J., Hamberger, B., Hartmann, A., Heider, H., Jardim, C., Julien-Laferriere, A., Kallscheuer, N., Kerbe, W., Kuipers, O. P., Li, S., Love, N., Marchetti-Spaccamela, A., Marienhagen, J., Martin, C., Mary, A., Mazurek, V., Meinhart, C., Sevillano, D. M., Menezes, R., Naesby, M., Nørholm, M. H. H., Okkels, F. T., Oliveira, J., Ottens, M., Parrot, D., Pei, L., Rocha, I., Rosado-Ramos, R., Rousseau, C., Sagot, M. F., dos Santos, C. N., Schmidt, M., Shelenga, T., Shepherd, L., Silva, A. R., da Silva, M. H., Simon, O., Stahlhut, S. G., Solopova, A., Sorokin, A., Stewart, D., Stougie, L., Su, S., Thole, V., Tikhonova, O., Trick, M., Vain, P., Veríssimo, A., Vila-Santa, A., Vinga, S., Vogt, M., Wang, L., Wang, L., Wei, W., Youssef, S., Neves, A. R. & Forster, J., 1 Apr 2018, In: Phytochemistry Reviews. 17, 2, p. 291-326 36 p.

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation

Almeida, A. F., Borge, G. I. A., Piskula, M., Tudose, A., Tudoreanu, L., Valentová, K., Williamson, G. & Santos, C. N., 1 May 2018, In: Comprehensive Reviews in Food Science and Food Safety. 17, 3, p. 714-731 18 p.

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells

Lopez de las Hazas, M-C., Godinho-Pereira, J., Macia, A., Filipa Almeida, A., Rita Ventura, M., Motilva, M-J. & Santos, C. N., Jul 2018, In: Journal of Functional Foods. 46, p. 110-117

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Polyphenols as new leads in drug discovery: Biological activity and mechanisms

dos Santos, C. N., Menezes, R. & Stewart, D., 1 Jan 2018, In: Current Pharmaceutical Design. 24, 19, p. 2041-2042 2 p.

Research output: Contribution to journal › Editorial › peer-review

6 Citations (Scopus)

Pure polyphenols applications for cardiac health and disease

Santos, C. N., Gomes, A., Oudot, C., Dias-Pedroso, D., Rodriguez-Mateos, A., Vieira, H. L. A. & Brenner, C., 2018, In: Current Pharmaceutical Design. 24, 19, p. 2137 - 2156

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

2017

(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways

Jardim, C., Macedo, D., Figueira, I., Dobson, G., McDougall, G. J., Stewart, D., Ferreira, R. B., Menezes, R. & Santos, C. N., 1 May 2017, In: Journal of Functional Foods. 32, p. 333-346 14 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

Garcia, G., Nanni, S., Figueira, I., Ivanov, I., McDougall, G. J., Stewart, D., Ferreira, R. B., Pinto, P., Silva, R. F. M., Brites, D. & Santos, C. N., 15 Jan 2017, In: Food Chemistry. 215, p. 274-283 10 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Cláudia Nunes dos Santos

Research output

Search results