• 3259 Citations
  • 25 h-Index
19972020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output at NOVA

2020

Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials

Raimundo, A. F., Félix, F., Andrade, R., García-Conesa, M. T., González-Sarrías, A., Gilsa-Lopes, J., do Ó, D., Raimundo, A., Ribeiro, R., Rodriguez-Mateos, A., Santos, C. N., Schär, M., Silva, A., Cruz, I., Wang, B., Pinto, P. & Menezes, R., 2020, In : European Journal of Nutrition.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Flavonoids as potential drugs for VPS13-dependent rare neurodegenerative diseases

Soczewka, P., Flis, K., Tribouillard-Tanvier, D., Di Rago, J. P., Santos, C. N., Menezes, R., Kaminska, J. & Zoladek, T., Jul 2020, In : Genes. 11, 7, p. 1-17 17 p., 828.

Research output: Contribution to journalArticle

Open Access

Natural Products: Optimizing Cancer Treatment through Modulation of Redox Balance

Rijo, P., Pešić, M., Fernandes, A. S. & Santos, C. N., 2020, In : Oxidative Medicine and Cellular Longevity. 2020, 2407074.

Research output: Contribution to journalReview article

Open Access
File
1 Downloads (Pure)

Second Food Bioactives and Health Conference

Dos Santos, C. N., 19 Feb 2020, In : Journal of Agricultural and Food Chemistry. 68, 7, p. 1761-1762 2 p.

Research output: Contribution to journalEditorial

2019

5-(Hydroxyphenyl)-γ-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: Evidence from different in silico, in vitro and in vivo experimental models

Angelino, D., Carregosa, D., Domenech-Coca, C., Savi, M., Figueira, I., Brindani, N., Jang, S., Lakshman, S., Molokin, A., Urban, J. F., Davis, C. D., Brito, M. A., Kim, K. S., Brighenti, F., Curti, C., Bladé, C., Del Bas, J. M., Stilli, D., Solano-Aguilar, G. I., Dos Santos, C. N. & 2 others, Del Rio, D. & Mena, P., 1 Nov 2019, In : Nutrients. 11, 11, 2678.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
2 Downloads (Pure)

Berry-enriched diet in salt-sensitive hypertensive rats: Metabolic fate of (poly)phenols and the role of gut microbiota

Gomes, A., Oudot, C., Macià, A., Foito, A., Carregosa, D., Stewart, D., Van de Wiele, T., Berry, D., Motilva, M. J., Brenner, C. & Dos Santos, C. N., 1 Nov 2019, In : Nutrients. 11, 11, 2634.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Figueira, I., Tavares, L., Jardim, C., Costa, I., Terrasso, A. P., Almeida, A. F., Govers, C., Mes, J. J., Gardner, R., Becker, J. D., McDougall, G. J., Stewart, D., Filipe, A., Kim, K. S., Brites, D., Brito, C., Brito, M. A. & Santos, C. N., 1 Feb 2019, In : European Journal of Nutrition. 58, 1, p. 113-130 18 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2 Citations (Scopus)

CSRP3 mediates polyphenols-induced cardioprotection in hypertension

Oudot, C., Gomes, A., Nicolas, V., Le Gall, M., Chaffey, P., Broussard, C., Calamita, G., Mastrodonato, M., Gena, P., Perfettini, J. L., Hamelin, J., Lemoine, A., Fischmeister, R., Vieira, H. L. A., Santos, C. N. & Brenner, C., 1 Apr 2019, In : Journal of Nutritional Biochemistry. 66, p. 29-42 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism

De Bruyne, T., Steenput, B., Roth, L., De Meyer, G. R. Y., Santos, C. N. D., Valentová, K., Dambrova, M. & Hermans, N., 8 Mar 2019, In : Nutrients. 11, 3

Research output: Contribution to journalReview article

Open Access
File
8 Citations (Scopus)
20 Downloads (Pure)

Identification and microbial production of the raspberry phenol salidroside that is active against huntington’s disease

Kallscheuer, N., Menezes, R., Foito, A., Da Silva, M. H., Braga, A., Dekker, W., Sevillano, D. M., Rosado-Ramos, R., Jardim, C., Oliveira, J., Ferreira, P., Rocha, I., Silva, A. R., Sousa, M., Allwood, J. W., Bott, M., Faria, N., Stewart, D., Ottens, M., Naesby, M. & 2 others, Dos Santos, C. N. & Marienhagen, J., 1 Mar 2019, In : Plant Physiology. 179, 3, p. 969-985 17 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

INFOGEST static in vitro simulation of gastrointestinal food digestion

Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., Clemente, A., Corredig, M., Dupont, D., Dufour, C., Edwards, C., Golding, M., Karakaya, S., Kirkhus, B., Le Feunteun, S., Lesmes, U. & 15 others, Macierzanka, A., Mackie, A. R., Martins, C., Marze, S., McClements, D. J., Ménard, O., Minekus, M., Portmann, R., Santos, C. N., Souchon, I., Singh, R. P., Vegarud, G. E., Wickham, M. S. J., Weitschies, W. & Recio, I., 1 Apr 2019, In : Nature Protocols. 14, 4, p. 991-1014 24 p.

Research output: Contribution to journalArticle

Open Access
123 Citations (Scopus)
5 Citations (Scopus)

Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)

Tur, J. A., Jacob, C., Chaimbault, P., Tadayyon, M., Richling, E., Hermans, N., Nunes dos Santos, C., Diederich, M., Giblin, L., Elhabiri, M., Gaucher, C., Andreoletti, P., Fernandes, A., Davies, M., Bartoszek, A. & Cherkaoui-Malki, M., 1 Jan 2019, In : Free Radical Research.

Research output: Contribution to journalComment/debate

Open Access
2 Citations (Scopus)

Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol

Dias-Pedroso, D., Guerra, J., Gomes, A., Oudot, C., Brenner, C., Santos, C. N. & Vieira, H. L. A., Apr 2019, In : Cardiovascular Toxicology. 19, 2, p. 156-167 11 p.

Research output: Contribution to journalArticle

RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild and cultivated berry fruit species with high content of phenolics

Thole, V., Bassard, J. E., Ramírez-González, R., Trick, M., Ghasemi Afshar, B., Breitel, D., Hill, L., Foito, A., Shepherd, L., Freitag, S., Nunes Dos Santos, C., Menezes, R., Banãdos, P., Naesby, M., Wang, L., Sorokin, A., Tikhonova, O., Shelenga, T., Stewart, D., Vain, P. & 1 others, Martin, C., 19 Dec 2019, In : BMC Genomics. 20, 1, 995.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)

The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism

Ferreira, C., Couceiro, J., Família, C., Jardim, C., Antas, P., Santos, C. N., Outeiro, T. F., Tenreiro, S. & Quintas, A., 8 Aug 2019, In : Fems Yeast Research. 19, 5, foz042.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

Macedo, D., Jardim, C., Figueira, I., Almeida, A. F., McDougall, G. J., Stewart, D., Yuste, J. E., Tomás-Barberán, F. A., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 3 May 2018, In : Scientific Reports. 8, 1, 6965.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
21 Downloads (Pure)

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., Bassard, J. E., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., Fernandes, A. & 63 others, Ferreira, P., Ferro, R., Foito, A., Freitag, S., Garcia, G., Gaspar, P., Godinho-Pereira, J., Hamberger, B., Hartmann, A., Heider, H., Jardim, C., Julien-Laferriere, A., Kallscheuer, N., Kerbe, W., Kuipers, O. P., Li, S., Love, N., Marchetti-Spaccamela, A., Marienhagen, J., Martin, C., Mary, A., Mazurek, V., Meinhart, C., Sevillano, D. M., Menezes, R., Naesby, M., Nørholm, M. H. H., Okkels, F. T., Oliveira, J., Ottens, M., Parrot, D., Pei, L., Rocha, I., Rosado-Ramos, R., Rousseau, C., Sagot, M. F., dos Santos, C. N., Schmidt, M., Shelenga, T., Shepherd, L., Silva, A. R., da Silva, M. H., Simon, O., Stahlhut, S. G., Solopova, A., Sorokin, A., Stewart, D., Stougie, L., Su, S., Thole, V., Tikhonova, O., Trick, M., Vain, P., Veríssimo, A., Vila-Santa, A., Vinga, S., Vogt, M., Wang, L., Wang, L., Wei, W., Youssef, S., Neves, A. R. & Forster, J., 1 Apr 2018, In : Phytochemistry Reviews. 17, 2, p. 291-326 36 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation

Almeida, A. F., Borge, G. I. A., Piskula, M., Tudose, A., Tudoreanu, L., Valentová, K., Williamson, G. & Santos, C. N., 1 May 2018, In : Comprehensive Reviews in Food Science and Food Safety. 17, 3, p. 714-731 18 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells

Lopez de las Hazas, M-C., Godinho-Pereira, J., Macia, A., Filipa Almeida, A., Rita Ventura, M., Motilva, M-J. & Santos, C. N., Jul 2018, In : Journal of Functional Foods. 46, p. 110-117

Research output: Contribution to journalArticle

14 Citations (Scopus)

Polyphenols as new leads in drug discovery: Biological activity and mechanisms

dos Santos, C. N., Menezes, R. & Stewart, D., 1 Jan 2018, In : Current Pharmaceutical Design. 24, 19, p. 2041-2042 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Pure polyphenols applications for cardiac health and disease

Santos, C. N., Gomes, A., Oudot, C., Dias-Pedroso, D., Rodriguez-Mateos, A., Vieira, H. L. A. & Brenner, C., 2018, In : Current Pharmaceutical Design. 24, 19, p. 2137 - 2156

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways

Jardim, C., Macedo, D., Figueira, I., Dobson, G., McDougall, G. J., Stewart, D., Ferreira, R. B., Menezes, R. & Santos, C. N., 1 May 2017, In : Journal of Functional Foods. 32, p. 333-346 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

Garcia, G., Nanni, S., Figueira, I., Ivanov, I., McDougall, G. J., Stewart, D., Ferreira, R. B., Pinto, P., Silva, R. F. M., Brites, D. & Santos, C. N., 15 Jan 2017, In : Food Chemistry. 215, p. 274-283 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Dairy products and inflammation: A review of the clinical evidence

Bordoni, A., Danesi, F., Dardevet, D., Dupont, D., Fernandez, A. S., Gille, D., Nunes dos Santos, C., Pinto, P., Re, R., Rémond, D., Shahar, D. R. & Vergères, G., 13 Aug 2017, In : Critical Reviews in Food Science and Nutrition. 57, 12, p. 2497-2525 29 p.

Research output: Contribution to journalReview article

62 Citations (Scopus)

Exploring the power of yeast to model aging and age-related neurodegenerative disorders

Oliveira, A. V., Vila�a, R., Santos, C. N., Costa, V. & Menezes, R., 1 Feb 2017, In : Biogerontology. 18, 1, p. 3-34 32 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Phycocyanin protects against Alpha-Synuclein toxicity in yeast

Macedo, D., Bertolin, T. E., Oro, T., Backes, L. T. H., Brás, I. C., Santos, C. N., Tenreiro, S. & Outeiro, T. F., 2017, In : Journal of Functional Foods. 38, p. 553-560 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Polyphenols beyond barriers: A glimpse into the brain

Figueira, I., Menezes, R., Macedo, D., Costa, I. & dos Santos, C. N., 1 May 2017, In : Current Neuropharmacology. 15, 4, p. 562-594 33 p.

Research output: Contribution to journalReview article

40 Citations (Scopus)

Polyphenols journey through blood-brain barrier towards neuronal protection

Figueira, I., Garcia, G., Pimpão, R. C., Terrasso, A. P., Costa, I., Almeida, A. F., Tavares, L., Pais, T. F., Ventura, M. R., Filipe, A., McDougall, G. J., Stewart, D., Kim, K. S., Palmela, I., Brites, D., Brito, M. A., Santos, C. N. & Brito, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 11456.

Research output: Contribution to journalArticle

47 Citations (Scopus)
6 Citations (Scopus)

Worldwide (poly)phenol intake: assessment methods and identified gaps

Pinto, P. & Santos, C. N., 1 Jun 2017, In : European Journal of Nutrition. 56, 4, p. 1393-1408 16 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)
2016

Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study

Rodriguez-Mateos, A., Feliciano, R. P., Boeres, A., Weber, T., Santos, M. C., Lima, M. R. & Heiss, C., 1 Oct 2016, In : Molecular Nutrition & Food Research. 60, 10, p. 2130-2140 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

High-throughput yeast-based reporter assay to identify compounds with anti-inflammatory potential

Garcia, G., do Santos, C. N. & Menezes, R., 1 Sep 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1449. p. 441-452 12 p. (Methods in Molecular Biology; vol. 1449).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols

Feliciano, R. P., Boeres, A., Massacessi, L., Istas, G., Lima, M. R., Nunes Dos Santos, C., Heiss, C. & Rodriguez-Mateos, A., 1 Jun 2016, In : Archives of Biochemistry and Biophysics. 599, p. 31-41 11 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
18 Citations (Scopus)

The harmonized INFOGEST in vitro digestion method: From knowledge to action

Egger, L., Ménard, O., Delgado-Andrade, C., Alvito, P., Assunção, R., Balance, S., Barberá, R., Brodkorb, A., Cattenoz, T., Clemente, A., Comi, I., Dupont, D., Garcia-Llatas, G., Lagarda, M. J., Le Feunteun, S., JanssenDuijghuijsen, L., Karakaya, S., Lesmes, U., Mackie, A. R., Martins, C. & 18 others, Meynier, A., Miralles, B., Murray, B. S., Pihlanto, A., Picariello, G., Santos, C. N., Simsek, S., Recio, I., Rigby, N., Rioux, L. E., Stoffers, H., Tavares, A., Tavares, L., Turgeon, S., Ulleberg, E. K., Vegarud, G. E., Vergères, G. & Portmann, R., 1 Oct 2016, In : Food Research International. 88, p. 217-225 9 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
2015

(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy

Macedo, D., Tavares, L., McDougall, G. J., Vicente Miranda, H., Stewart, D., Boavida, R., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 2015, In : Human molecular genetics. 24, 6, p. 1717-1732 16 p., ddu585.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation

Gomes, A., Pimpão, R. C., Fortalezas, S., Figueira, I., Miguel, C., Aguiar, C., Salgueiro, L., Cavaleiro, C., Gonçalves, M. J., Clemente, A., Costa, C., Martins-Loução, M. A., Boavida, R. & Santos, C. N., 5 Nov 2015, In : Industrial Crops and Products. 74, p. 505-513 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

From the baker to the bedside: yeast models of Parkinson's disease

Menezes, R., Macedo, D. L. C., Santos, M. C., Tenreiro, S. & Outeiro, T. F., Aug 2015, In : Microbial Cell. 2, 8, p. 262-279 18 p.

Research output: Contribution to journalReview article

Open Access
File
36 Citations (Scopus)
19 Downloads (Pure)

Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols

Bohn, T., Mcdougall, G. J., Alegría, A., Alminger, M., Arrigoni, E., Aura, A. M., Brito, C., Cilla, A., El, S. N., Karakaya, S., Martínez-Cuesta, M. C. & Santos, C. N., 1 Jul 2015, In : Molecular Nutrition & Food Research. 59, 7, p. 1307-1323 17 p.

Research output: Contribution to journalReview article

107 Citations (Scopus)

Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée

Pimpão, R. C., Lima, M. R., Boavida, R., Williamson, G. & Santos, C. N., 14 Feb 2015, In : British Journal Of Nutrition. 113, 3, p. 454-463 10 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

Rémond, D., Shahar, D. R., Gille, D., Pinto, P., Kachal, J., Peyron, M. A., Santos, M. C., Walther, B., Bordoni, A., Dupont, D., Tomás-Cobos, L. & Vergères, G., 2015, In : Oncotarget. 6, 16, p. 13858-13898 41 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2014

A standardised static in vitro digestion method suitable for food-an international consensus

Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., Dufour, C., Egger, L., Golding, M., Karakaya, S., Kirkhus, B., Le Feunteun, S., Lesmes, U., MacIerzanka, A., MacKie, A., Marze, S. & 9 others, McClements, D. J., Ménard, O., Recio, I., Santos, C. N., Singh, R. P., Vegarud, G. E., Wickham, M. S. J., Weitschies, W. & Brodkorb, A., 2014, In : Food and Function. 5, 6, p. 1113-1124 12 p.

Research output: Contribution to journalArticle

1424 Citations (Scopus)

In vitro models for studying secondary plant metabolite digestion and bioaccessibility

Alminger, M., Aura, A. M., Bohn, T., Dufour, C., El, S. N., Gomes, A., Karakaya, S., Martínez-Cuesta, M. C., Mcdougall, G. J., Requena, T. & Santos, C. N., 2014, In : Comprehensive Reviews in Food Science and Food Safety. 13, 4, p. 413-436 24 p.

Research output: Contribution to journalReview article

137 Citations (Scopus)

Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

Tenreiro, S., Reimão-Pinto, M. M., Antas, P., Rino, J., Wawrzycka, D., Macedo, D., Rosado-Ramos, R., Amen, T., Waiss, M., Magalhães, F., Gomes, A., Santos, C. N., Kaganovich, D. & Outeiro, T. F., 2014, In : PLoS Genetics. 10, 5, e1004302.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers

Pimpão, R. C., Dew, T., Figueira, M. E., Mcdougall, G. J., Stewart, D., Ferreira, R. B., Santos, C. N. & Williamson, G., 2014, In : Molecular Nutrition & Food Research. 58, 7, p. 1414-1425 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae

Pimentel, C., Caetano, S. M., Menezes, R., Figueira, I., Santos, C. N., Ferreira, R. B., Santos, M. A. S. & Pousada, C. A., 2014, In : Biochimica Et Biophysica Acta-General Subjects. 1840, 6, p. 1977-1986 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013
Open Access
28 Citations (Scopus)

beta-N-Acetylhexosaminidase involvement in alpha-conglutin mobilization in Lupinus albus

Santos, M. C., 1 Jan 2013, In : Journal Of Plant Physiology. 170, 12, p. 1047-1056

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)