António José Cabrita Lucas Laires

  • 1448 Citations
  • 22 h-Index
1982 …2012
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Research Output at NOVA 1982 2012

Article
11 Citations (Scopus)
Biomimetics
Oxygen
Amines
tert-Butylhydroperoxide
2-amino-3-methylimidazo(4,5-f)quinoline
82 Citations (Scopus)
Open Access
25 Citations (Scopus)
Escherichia coli K12
Salmonella
Coenzymes
Enzyme activity
Salmonella typhimurium
82 Citations (Scopus)
44 Citations (Scopus)

Cytogenetic alterations and oxidative stress in thyroid cancer patients after iodine-131 therapy

Gil, O. M., Oliveira, N. G., Rodrigues, A. S., Laires, A., Ferreira, T. C., Limbert, E., Leonard, A., Gerber, G. & Rueff, J., 2000, In : Mutagenesis. 15, 1, p. 69-75

Research output: Contribution to journalArticle

42 Citations (Scopus)
5 Citations (Scopus)

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells.

Dinis, J., Silva, V., Gromicho, M., Martins, C., Laires, A., Tavares, P., Rendeiro, P., Torres, F., Rueff, J. & Rodrigues, AS., 2012, In : Leukemia & Lymphoma. 53, 10, p. 2004-14 11 p.

Research output: Contribution to journalArticle

K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Damage
DNA Repair
Protein-Tyrosine Kinases
70 Citations (Scopus)

Elevated levels of DNA-protein crosslinks and micronuclei in peripheral lymphocytes of tannery workers exposed to trivalent chromium

Medeiros, MG., Rodrigues, AS., Batoreu, MC., Laires, A., Rueff, J. & Zhitkovich, A., Jan 2003, In : Mutagenesis. 18, 1, p. 19-24

Research output: Contribution to journalArticle

29 Citations (Scopus)
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Protein Isoforms
Escherichia coli
22 Citations (Scopus)

Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems

Kranendonk, M., Fisher, C. W., Roda, R., Carreira, F., Theisen, P., Laires, A., Rueff, J., Vermeulen, N. P. E. & Estabrook, R. W., 19 Feb 1999, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 439, 2, p. 287-300 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Escherichia coli
Oxidoreductases
15 Citations (Scopus)

Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen

Martins, C., Cação, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J. & Rodrigues, A. S., 2012, In : Mutation Research-Genetic Toxicology And Environmental Mutagenesis. 747, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Mutagens
Carcinogens
Comet Assay
Food
DNA Adducts
41 Citations (Scopus)

Expression of human cytochrome P450 1A2 in Escherichia coli: A system for biotransformation and genotoxicity studies of chemical carcinogens

Kranendonk, M., Mesquita, P., Laires, A., Vermeulen, N. P. E. & Rueff, J., May 1998, In : Mutagenesis. 13, 3, p. 263-269 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Biotransformation
Carcinogens
Escherichia coli
Rats
73 Citations (Scopus)

Genetic toxicology of flavonoids: The role of metabolic conditions in the induction of reverse mutation, SOS functions and sisterchromatid exchanges

Rueff, J., Laires, A., Borba, H., Chaveca, T., Gomes, M. I. & Halpern, M., May 1986, In : Mutagenesis. 1, 3, p. 179-183 5 p.

Research output: Contribution to journalArticle

Toxicology
Flavonoids
Wine
Quercetin
Glycosides
31 Citations (Scopus)

Genomics and Cancer Drug Resistance

Rodrigues, A. S., Dinis, J., Gromicho, M., Martins, C., Laires, A. & Rueff, J., 1 Jan 2012, In : Current Pharmaceutical Biotechnology. 13, 5, p. 651-673

Research output: Contribution to journalArticle

5 Citations (Scopus)
50 Citations (Scopus)

Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol

Maralhas, A., Monteiro, A., Martins, C., Kranendonk, M., Laires, A., Rueff, J. & Rodrigues, A. S., 2006, In : Mutagenesis. 21, 3, p. 199-204 5 p.

Research output: Contribution to journalArticle

Endoreduplication
Eugenol
Type II DNA Topoisomerase
Food
Aberrations
18 Citations (Scopus)

Genotoxicity assessment of aromatic-amines and amides in genetically-engineered v79 cells

Silva, ID., Caria, M. H., Laires, A., Chaveca, T., Glatt, HR., Rueff, J. & Rodrigues, AS., Dec 1994, In : Mutation research-Genetic toxicology. 341, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
Tyramine
Wine
Nitrosation
tyramine
genotoxicity
73 Citations (Scopus)
Kinetochores
Micronucleus Tests
Lymphocytes
Quercetin
Assays
83 Citations (Scopus)
45 Citations (Scopus)
12 Citations (Scopus)
Mutagens
Escherichia coli
DNA Repair
Lipopolysaccharides
Arginine
68 Citations (Scopus)

Lipoperoxidation products and thiol antioxidants in chromium exposed workers

Goulart, M., Batoréu, M. C., Rodrigues, A. S., Laires, A. J. C. L. & Rueff, J., Sep 2005, In : Mutagenesis. 20, 5, p. 311-315 5 p.

Research output: Contribution to journalArticle

Open Access
Chromium
Sulfhydryl Compounds
Antioxidants
Creatinine
Urine
14 Citations (Scopus)

Mechanisms of myricetin mutagenicity in V79 cells: Involvement of radicalar species

Duarte Silva, I., Gaspar, J., Rodrigues, A., Gomes da Costa, G., Laires, A. & Rueff, J., 1996, In : Teratogenesis Carcinogenesis And Mutagenesis. 16, 5, p. 253-268 16 p.

Research output: Contribution to journalArticle

Rats
Cells
Cytochrome P-450 CYP2B1
Cell Line
Cytochrome P-450 CYP1A2
37 Citations (Scopus)
15 Citations (Scopus)

Mutagenic activity in the wine-making process: Correlations with rutin and quercetin levels

Rueff, J., Laires, A., Gaspar, J. & Rodrigues, A., Jul 1990, In : Mutagenesis. 5, 4, p. 393-396 4 p.

Research output: Contribution to journalArticle

Rutin
Wine
Quercetin
Mutagens
Flavonoids
6 Citations (Scopus)
Nitrosation
Gastric Juice
Glycine
Chlorides
Stomach
4 Citations (Scopus)

Mutagenicity in urine of workers in naval industry.

Rueff, J., Laires, A., Gomes, M. I., Borba, H., Magalhães, J. & Halpern, M., 1 Dec 1982, In : Progress in clinical and biological research. 109, p. 443-452 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mutagenicity of kaempferol in V79 cells: The role of cytochromes P450

Duarte Silva, I., Rodrigues, A., Gaspar, J., Maia, R., Laires, A. & Rueff, J., 1996, In : Teratogenesis Carcinogenesis And Mutagenesis. 16, 4, p. 229-241 13 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Aberrations
Chromosome Aberrations
Quercetin
High pressure liquid chromatography
17 Citations (Scopus)
Galactosides
Rutin
Enzymatic hydrolysis
mutagenicity
Quercetin
21 Citations (Scopus)

MX100, a new Escherichia coli tester strain for use in genotoxicity studies

Kranendonk, M., Pintado, F., Mesquita, P., Laires, A., Vermeulen, N. P. E. & Rueff, J., Jul 1996, In : Mutagenesis. 11, 4, p. 327-333 7 p.

Research output: Contribution to journalArticle

Mutagens
Escherichia coli
Escherichia coli K12
Arginine
4-Nitroquinoline-1-oxide
3 Citations (Scopus)
13 Citations (Scopus)

No evidence of increased chromosomal aberrations and micronuclei in lymphocytes from nonfamilial thyroid cancer patients prior to radiotherapy

Gil, O. M., Oliveira, N. G., Rodrigues, A. S., Laires, A., Ferreira, T. C., Limbert, E. & Rueff, J., Nov 2000, In : Cancer Genetics And Cytogenetics. 123, 1, p. 55-60

Research output: Contribution to journalArticle

63 Citations (Scopus)

On the mechanisms of genotoxicity and metabolism of quercetin

Gaspar, J., Rodrigues, A., Laires, A., Silva, F., Costa, S., Monteiro, M. J., Monteiro, C. & Rueff, J., Sep 1994, In : Mutagenesis. 9, 5, p. 445-449 5 p.

Research output: Contribution to journalArticle

Quercetin
Aberrations
Metabolism
Aberration
Ethylenediaminetetraacetic acid
46 Citations (Scopus)
Quercetin
Oxygen
Superoxide Dismutase
Antioxidants
10 Citations (Scopus)

Possible transient adaptive response to mitomycin C in peripheral lymphocytes from thyroid cancer patients after iodine-131 therapy

Gil, O. M., Oliveira, N. G., Rodrigues, A. S., Laires, A., Ferreira, T. C., Limbert, E. & Rueff, J., 1 Jan 2002, In : International Journal of Cancer. 102, 6, p. 556-561

Research output: Contribution to journalArticle

34 Citations (Scopus)

Quercetin and the mutagenicity of wines

Gaspar, J., Laires, A., Monteiro, M., Laureano, O. & Ramos, E., 1 Jan 1993, In : Mutagenesis. 8, 1, p. 51-55 5 p.

Research output: Contribution to journalArticle

Wine
Quercetin
Flavonoids
Mutagens
Rutin
22 Citations (Scopus)

Structural requirements for mutagenicity of flavonoids upon nitrosation. A structure-activity study

Rueff, J., Gaspar, J. & Laires, A., 1 Jul 1995, In : Mutagenesis. 10, 4, p. 325-328 4 p.

Research output: Contribution to journalArticle

Nitrosation
Flavonoids
Mutagens
Chemical reactions
Catechin
19 Citations (Scopus)
Cytochromes b5
Cytochrome P-450 CYP1A2
Biotransformation
Human Activities
Cytochrome P-450 Enzyme System
27 Citations (Scopus)

Urinary mutagenicity in occupational exposure to mineral oils and iron oxide particles

Laires, A., Borba, H., Rueff, J., Gomes, M. I. & Halpern, M., 1982, In : Carcinogenesis. 3, 9, p. 1077-1079 3 p.

Research output: Contribution to journalArticle

Mineral Oil
Mineral oils
Occupational Exposure
Iron oxides
Iron
Chapter

Biomarkers of Chromium Exposure and Cytogenetic damage in Leather Tanning and Welding Industry Workers

Medeiros, M. G., Rodrigues, A., Batoreu, C., Laires, A., Rueff, J. & Zhitkovich, A., 1 Jan 2003, Human Monitoring for Genetic Effects. N. S. S. (ed.). IOS Press

Research output: Chapter in Book/Report/Conference proceedingChapter

Conference contribution

Activation of promutagens by rat cyp p450 expressing v79 cells

Rodrigues, AS., Silva, ID., Monteiro, M. J., Caria, H., Laires, A., Chaveca, T. & Rueff, J., 1994, CYTOCHROME P450. Lechner, MC. (ed.). JOHN LIBBEY EUROTEXT LTD, p. 205-208 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

DNA DAMAGE AND OXYGEN SPECIES

Rueff, J., Laires, A., Brás, A., Borba, H., Chaveca, T., Gaspar, J., Rordrigues, A., Cristovão, L. & Monteiro, M., 1989, DNA REPAIR MECHANISMS AND THEIR BIOLOGICAL IMPLICATIONS IN MAMMALIAN CELLS. LAMBERT, MW. & LAVAL, J. (eds.). PLENUM PRESS DIV PLENUM PUBLISHING CORP, p. 171-181 11 p. (NATO ADVANCED SCIENCE INSTITUTES SERIES, SERIES A, LIFE SCIENCES; vol. 182).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Literature review
60 Citations (Scopus)

Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays

Rueff, J., Chiapella, C., Chipman, JK., Darroudi, F., Silva, ID., DuvergervanBogaert, M., Fonti, E., Glatt, HR., Isern, P., Laires, A., Leonard, A., Llagostera, M., Mossesso, P., Natarajan, AT., Palitti, F., Rodrigues, AS., Schinoppi, A., Turchi, G. & WerleSchneider, G., 12 Jun 1996, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 353, 1-2, p. 151-176 26 p.

Research output: Contribution to journalLiterature review

Meeting Abstract

BIOMIMETIC ACTIVATION OF PREMUTAGENS WITH FETPP AND VARIOUS OXYGEN DONORS

Rodrigues, AS., Rueff, J., Laires, A. & Gaspar, J., Apr 1992, In : Mutation research. 271, 2, p. 158-158 1 p.

Research output: Contribution to journalMeeting Abstract

Chemical-stability of quercetin - influence on its genotoxicity

Laires, A., Rueff, J., Rodrigues, AS., Gaspar, J., Chaveca, T. & David, V., Oct 1989, In : Mutation research. 216, 5, p. 300-300 1 p.

Research output: Contribution to journalMeeting Abstract

MUTAGENIC ACTIVITY IN ALCOHOLIC FERMENTATION

Laires, A., Rueff, J., Gaspar, J. & Rodrigues, AS., Jun 1988, In : Mutation research. 203, 3, p. 238-239 2 p.

Research output: Contribution to journalMeeting Abstract