Research Output per year
Personal profile
Research interests
As Research Assistant Professor in the Macromolecular Crystallography Research Lab at Universidade NOVA de Lisboa, since November 2003, my main research interest has been the functional and structural characterization of different proteins, using the powerful information provided by X-ray Crystallography. The atomic level information obtained allows drawing conclusions related to macromolecular interactions, either protein-protein or protein-ligand.
I have been thorougly characterizing a megaDalton complex, the Cellulosome, present in some anaerobic bacteria and fungi and of biotechnological relevance.
Related to this research project, I have coordinated, as PI, the national research projects PTDC/QUI-BIQ/100359/2008 and PTDC/QUI/68286/2006, and participate in projects PTDC/BIA-MIC/5947/2014, PTDC/QUI-QUI/112537/2009, PTDC/BIA-PRO/103980/2008 and POCI/PPCDT/BIA-PRO/59118/2004, as member of the research team.
Currently, i am PI of project PTDC/BBB-BEP/0869/2014, beginning in January 2016.
I have also participated in the structural characterization of proteins from different biological systems. My expertise in the structural characterization of oligosaccharide-recognition systems is also focused in protein-glycan recognition in cancer interactions (a project awarded with the Santander-Totta/NOVA Scientific Merit Prize and the Bluepharma/Universidade de Coimbra Innovation Award).
In the Macromolecular Crystalography Research Lab, we have pioneered the knowledge on cellulosomal protein-protein complexes, and the same approaches and methodologies are being applied to tackle protein-ligand interactions for biomedical relevant systems.
I am also dedicated to more methodological questions, like the study of the phenomena behind protein crystallization. More specifically, I study the improvement of protein crystal growth and phasing using nanoparticles and/or ionic liquid compounds.
To gather resources to support the group's research, we relied on FCT project RECI/BBB-BEP/0124/2012, which I also coordinated, as PI.
Education/Academic qualification
Structural biology, Doctorate, Faculdade de Ciências e Tecnologia (FCT)
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- 15 Similar Profiles
Cellulosomes
Medicine & Life Sciences
Clostridium thermocellum
Medicine & Life Sciences
Crystallization
Chemical Compounds
Glucans
Medicine & Life Sciences
Proteins
Chemical Compounds
Ligands
Medicine & Life Sciences
Carbohydrates
Medicine & Life Sciences
Clostridium
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1997 2018
1
Citation
(Scopus)
5
Downloads
(Pure)
Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction
Bule, P., Pires, V. M. R., Alves, V. D., Carvalho, A. L., Prates, J. A. M., Ferreira, L. M. A., Smith, S. P., Gilbert, H. J., Noach, I., Bayer, E. A., Najmudin, S. & Fontes, C. M. G. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 6987.Research output: Contribution to journal › Article
Open Access
File
Cellulosomes
Ruminococcus
Rumen
Cellulose
Polysaccharides
Molecular Recognition of a Thomsen–Friedenreich Antigen Mimetic Targeting Human Galectin-3
Santarsia, S., Grosso, A. S., Trovão, F., Jiménez-Barbero, J., Carvalho, A. L., Nativi, C. & Marcelo, F., 8 Oct 2018, In : Chemmedchem. 13, 19, p. 2030-2036 7 p.Research output: Contribution to journal › Article
Galectin 3
Molecular recognition
Antigens
Neoplasm Metastasis
Neoplasms
Novel insights into the degradation of β-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase
Kumar, K., Correia, M. A. S., Pires, V. M. R., Dhillon, A., Sharma, K., Rajulapati, V., Fontes, C. M. G. A., Carvalho, A. L. & Goyal, A., 1 Oct 2018, In : International Journal of Biological Macromolecules. 117, p. 890-901 12 p.Research output: Contribution to journal › Article
Open Access
Cellulosomes
Clostridium thermocellum
Clostridium
Glucans
Glycoside Hydrolases
Structural elucidation of macromolecules
Romão, M. J., Santos-Silva, T. S., Carvalho, A. L., Cabrita, E. J. & Marcelo, F. M. B. M., 2018, Essential Techniques for Medical and Life Scientists : A Guide to Contemporary Methods and Current Applications With the Protocols. Bentham Science Publishers Ltd., Vol. Pt.1. p. 30-91 61 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Macromolecules
Ligands
X ray crystallography
X ray scattering
Nucleic Acids
3
Citations
(Scopus)
1
Downloads
(Pure)
Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H)-Anthrone
Peixoto, D., Figueiredo, M., Malta, G., Roma-Rodrigues, C., Baptista, P. V., Fernandes, A. R., Barroso, S., Carvalho, A. L., Afonso, C. A. M., Ferreira, L. M. & Branco, P. S., 31 Jan 2018, In : European Journal of Organic Chemistry. 2018, 4, p. 545-549 5 p.Research output: Contribution to journal › Article
Open Access
File
Cytotoxicity
cultured cells
deoxyribonucleic acid
Cells
evaluation
Prizes
Engenharia de anticorpos para o Tratamento do cancro da mama
Carlos Manuel Mendes Novo (Recipient), Paula Alexandra Videira (Recipient), José Ramalho (Recipient), Maria Angelina de Sá Palma (Recipient) & Ana Luisa Carvalho (Recipient), 2013
Prize: Fellowship awarded competitively
Trifunctional antibodies and dendritic cell-based technologies: a combined approach to cancer immunotherapy
Carlos Manuel Mendes Novo (Recipient), Paula Alexandra Videira (Recipient), José Ramalho (Recipient), Maria Angelina de Sá Palma (Recipient) & Ana Luisa Carvalho (Recipient), 2013
Prize: Fellowship awarded competitively