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Personal profile

Research interests

As Research Assistant Professor in the Macromolecular Crystallography Research Lab at Universidade NOVA de Lisboa, since November 2003, my main research interest has been the functional and structural characterization of different proteins, using the powerful information provided by X-ray Crystallography. The atomic level information obtained allows drawing conclusions related to macromolecular interactions, either protein-protein or protein-ligand.

I have been thorougly characterizing a megaDalton complex, the Cellulosome, present in some anaerobic bacteria and fungi and of biotechnological relevance. 
Related to this research project, I have coordinated, as PI, the national research projects PTDC/QUI-BIQ/100359/2008 and PTDC/QUI/68286/2006, and participate in projects PTDC/BIA-MIC/5947/2014, PTDC/QUI-QUI/112537/2009, PTDC/BIA-PRO/103980/2008 and POCI/PPCDT/BIA-PRO/59118/2004, as member of the research team. 
Currently, i am PI of project PTDC/BBB-BEP/0869/2014, beginning in January 2016.

I have also participated in the structural characterization of proteins from different biological systems. My expertise in the structural characterization of oligosaccharide-recognition systems is also focused in protein-glycan recognition in cancer interactions (a project awarded with the Santander-Totta/NOVA Scientific Merit Prize and the Bluepharma/Universidade de Coimbra Innovation Award). 

In the Macromolecular Crystalography Research Lab, we have pioneered the knowledge on cellulosomal protein-protein complexes, and the same approaches and methodologies are being applied to tackle protein-ligand interactions for biomedical relevant systems. 

I am also dedicated to more methodological questions, like the study of the phenomena behind protein crystallization. More specifically, I study the improvement of protein crystal growth and phasing using nanoparticles and/or ionic liquid compounds. 
To gather resources to support the group's research, we relied on FCT project RECI/BBB-BEP/0124/2012, which I also coordinated, as PI.

Education/Academic qualification

Structural biology, Doctorate, Faculdade de Ciências e Tecnologia (FCT)

Fingerprint Dive into the research topics where Ana Luisa Carvalho is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Cellulosomes Medicine & Life Sciences
Clostridium thermocellum Medicine & Life Sciences
Crystallization Chemical Compounds
Glucans Medicine & Life Sciences
Proteins Chemical Compounds
Ligands Medicine & Life Sciences
Carbohydrates Medicine & Life Sciences
Clostridium Chemical Compounds

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Research Output at NOVA 1997 2019

1 Citation (Scopus)
6 Downloads (Pure)

Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction

Bule, P., Pires, V. M. R., Alves, V. D., Carvalho, A. L., Prates, J. A. M., Ferreira, L. M. A., Smith, S. P., Gilbert, H. J., Noach, I., Bayer, E. A., Najmudin, S. & Fontes, C. M. G. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 6987.

Research output: Contribution to journalArticle

Open Access
File
Cellulosomes
Ruminococcus
Rumen
Cellulose
Polysaccharides
2 Citations (Scopus)

Molecular Recognition of a Thomsen–Friedenreich Antigen Mimetic Targeting Human Galectin-3

Santarsia, S., Grosso, A. S., Trovão, F., Jiménez-Barbero, J., Carvalho, A. L., Nativi, C. & Marcelo, F., 8 Oct 2018, In : Chemmedchem. 13, 19, p. 2030-2036 7 p.

Research output: Contribution to journalArticle

Galectin 3
Molecular recognition
Antigens
Neoplasm Metastasis
Neoplasms
2 Citations (Scopus)

Novel insights into the degradation of β-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase

Kumar, K., Correia, M. A. S., Pires, V. M. R., Dhillon, A., Sharma, K., Rajulapati, V., Fontes, C. M. G. A., Carvalho, A. L. & Goyal, A., 1 Oct 2018, In : International Journal of Biological Macromolecules. 117, p. 890-901 12 p.

Research output: Contribution to journalArticle

Open Access
Cellulosomes
Clostridium thermocellum
Clostridium
Glucans
Glycoside Hydrolases

Structural elucidation of macromolecules

Romão, M. J., Santos-Silva, T. S., Carvalho, A. L., Cabrita, E. J. & Marcelo, F. M. B. M., 2018, Essential Techniques for Medical and Life Scientists : A Guide to Contemporary Methods and Current Applications With the Protocols. Bentham Science Publishers Ltd., Vol. Pt.1. p. 30-91 61 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Macromolecules
Ligands
X ray crystallography
X ray scattering
Nucleic Acids