• 1222 Citations
  • 18 h-Index

Research output per year

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Personal profile

Research interests

I've completed PhD in Structural Biology in 2002 and presently hold a position as Research Assistant Professor at UCIBIO-NOVA, started in 2003.

My present research interests are focused in the search for uncharacterised biological protein-carbohydrate interactions with potential biotechnological use in nutrition, in pharma and in the biofuel industry. For this, among other structural biology and biophysics methods, I use the powerful information provided by X-ray Crystallography, which allows drawing conclusions related to macromolecular interactions, either protein-protein or protein-ligand. Additionally, I've also been strongly dedicated to the study of the phenomena behind protein crystallisation and new methods to improve it.

I have completed the supervision of 3 PhD students (one awarded the Antonio Xavier Prize for the Best Thesis in 2013) and presently supervise 3 PhD students, from the MolBios and Biochemistry Doctoral programs, 1 of them concluding her Thesis in 2020. I have also trained 6 MSc students, 5 hired Post-Doctoral Fellows, and 14 other post-graduate students. Additionally, I have tutored 18 under-graduate students.

In the beginning of my contract as Researcher, I held a contract as Invited Assistant Professor of FCT-NOVA, for 5 years. Additionally, I was a member of the Scientific Council of FCT-NOVA, from 2012 to 2015. I keep a regular support to 2nd and 3rd cycles in the Biochemistry section in FCT-NOVA and other institutions, when invited. I have organised several hands-on advanced courses, notably 2 editions (2014 and 2015) of the Instruct-ERIC/COST-supported international course ISBIO (https://eventos.fct.unl.pt/isbio) and a 3rd edition to be held in July 2021.

As Principal Investigator, I have coordinated 4 national FCT-MCTES funded projects and was member of team in 12 other projects. I have also integrated the winning teams of the Santander-Totta Scientific Merit Award, in 2012, and the Bluepharma Innovation Award, in 2013. Up to January 2020, my research activity has produced 46 peer-reviewed publications and 5 book chapters, 20 invited and 17 co-authored oral communications. I have co-authored more than 80 poster communications (6 awarded as Best Poster). I’m Guest Editor of a Special Issue from open access journal Crystals (MDPI Publishers; https://www.mdpi.com/journal/crystals/special_issues/novel_protein). 

As science outreach activities, I have dynamized the celebrations of the International Year of Crystallography, in 2014, and the International Year of Chemistry, in 2011. From 2006-2012, I was regular translator of the Science-in-School magazine. I maintain the group's social network website (https://www.facebook.com/XtalNOVA) and my own (https://docentes.fct.unl.pt/almc/). From January 2020, I was assigned duties as Ambassador for the Science Communication & Outreach of the XTAL research lab.

Education/Academic qualification

Structural biology, Doctorate, Faculdade de Ciências e Tecnologia (FCT)

Award Date: 15 Nov 2002

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Research Output at NOVA

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Gomes, A. S., Ramos, H., Gomes, S., Loureiro, J. B., Soares, J., Barcherini, V., Monti, P., Fronza, G., Oliveira, C., Domingues, L., Bastos, M., Dourado, D. F. A. R., Carvalho, A. L., Romão, M. J., Pinheiro, B., Marcelo, F., Carvalho, A., Santos, M. M. M. & Saraiva, L., 1 Jan 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 1, 129440.

Research output: Contribution to journalArticle

Open Access
  • 4 Citations (Scopus)
  • 2 Citations (Scopus)

    Resistance to Aminoglycosides: Glycomics and the Link to the Human Gut Microbiome

    Correia, V. G., Pinheiro, B. A., Carvalho, A. L. & Palma, A. S., 9 Sep 2019, Antibiotic Drug Resistance. Capelo‐Martínez, JL. & Igrejas, G. (eds.). John Wiley & Sons, Inc.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction

    Bule, P., Pires, V. M. R., Alves, V. D., Carvalho, A. L., Prates, J. A. M., Ferreira, L. M. A., Smith, S. P., Gilbert, H. J., Noach, I., Bayer, E. A., Najmudin, S. & Fontes, C. M. G. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 6987.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Citations (Scopus)
    20 Downloads (Pure)


    • 1 Editorial activity

    Crystals (Journal)

    Ana Luisa Carvalho (Guest editor)


    Activity: Publication peer-review and editorial workEditorial activity