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Research Output at NOVA 2000 2019

2019

Affinity-Triggered Assemblies Based on a Designed Peptide–Peptide Affinity Pair

Fernandes, C. S. M., Pina, A. S., Barbosa, A. J. M., Padrão, I., Duarte, F., Teixeira, C. A. S., Alves, V., Gomes, P., Fernandes, T. G., Dias, A. M. G. C. & Roque, A. C. A., 1 Nov 2019, In : Biotechnology Journal. 14, 11, 1800559.

Research output: Contribution to journalArticle

Hydrogels
Peptides
Proline
Culture Media
Stem Cells
4 Downloads (Pure)

An optimized e-nose for efficient volatile sensing and discrimination

Santos, G., Alves, C., Pádua, A. C., Palma, S., Gamboa, H. & Roque, A. C., 1 Jan 2019, BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. Roque, A., Fred, A. & Gamboa, H. (eds.). SciTePress, p. 36-46 11 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

File
Volatile organic compounds
Biomaterials
Food safety
Beverages
Cosmetics
1 Citation (Scopus)
Serum Albumin
Ligands
Triazines
Plasma (human)
Biomarkers
Open Access
Volatile Organic Compounds
Gelatin
Film thickness
Gels
Gases

Enhanced gas sensing with soft functional materials

Palma, S. I. C. J., Esteves, C., Pádua, A. C. C. S., Alves, C. M., Santos, G. M. C., Costa, H. M. A., Dionisio, M., Gamboa, H., Gruber, J. & Roque, A. C. A., 1 May 2019, ISOEN 2019 - 18th International Symposium on Olfaction and Electronic Nose, Proceedings. Institute of Electrical and Electronics Engineers Inc., 8823178

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Functional materials
Gels
gels
volatile organic compounds
Volatile organic compounds

Foreword

Roque, A., Fred, A. & Gamboa, H., 1 Jan 2019, BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. Roque, A., Fred, A. & Gamboa, H. (eds.). SciTePress, p. IX-XI

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Open Access
1 Citation (Scopus)

Free Marine Natural Products Databases for Biotechnology and Bioengineering

Barbosa, A. J. M. & Roque, A. C. A., 1 Nov 2019, In : Biotechnology Journal. 14, 11, 1800607.

Research output: Contribution to journalReview article

Bioengineering
Biotechnology
Biological Products
Databases
Military Personnel
12 Citations (Scopus)
40 Downloads (Pure)
Open Access
File
Anti-Bacterial Agents
Technology
Health Care Costs
Anti-Infective Agents
Microbiology

Impact of sensing film's production method on classification accuracy by electronic nose

Pádua, A., Gruber, J., Gamboa, H. & Roque, A. C., 1 Jan 2019, BIODEVICES 2019 - 12th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. Roque, A., Fred, A. & Gamboa, H. (eds.). SciTePress, p. 56-64 9 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Spin coating
Coatings
Sensor arrays
Decision trees
Volatile organic compounds
Peptidomimetics
Phosphoproteins
Cyclic Peptides
peptides
Peptides
2018
4 Citations (Scopus)

Design and evolution of an opto-electronic device for VOCs detection

Pádua, A. C., Palma, S., Gruber, J., Gamboa, H. & Roque, A. C., 2018, BIODEVICES 2018 - 11th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018. Bermudez i Badia, S., Cliquet, A., Cliquet, A., Gamboa, H. & Fred, A. (eds.). SciTePress, Vol. 1. p. 48-55 8 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Volatile organic compounds
Optoelectronic devices
Optical devices
Electronic nose
Electric properties
3 Citations (Scopus)

Engineered Protein Variants for Bioconjugation

Fernandes, C. S. M., Teixeira, G. D. G., Iranzo, O. & Roque, A. C. A., 3 Mar 2018, Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Elsevier, p. 105-138 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amino acids
Proteins
Amino Acids
Organic Chemistry
Genetic engineering
9 Citations (Scopus)
3 Downloads (Pure)
Open Access
File
Volatile Organic Compounds
Meta-Analysis
Smell
Information Storage and Retrieval
Artificial Intelligence
12 Citations (Scopus)
21 Downloads (Pure)

Protein- and Peptide-Based Biosensors in Artificial Olfaction

Barbosa, A. J. M., Oliveira, A. R. & Roque, A. C. A., 1 Dec 2018, In : Trends In Biotechnology. 36, 12, p. 1244-1258 15 p.

Research output: Contribution to journalReview article

Open Access
File
Odorant Receptors
Smell
Biosensing Techniques
Biosensors
Peptides
1 Citation (Scopus)

Scalable and easy-to-use system architecture for electronic noses

Pádua, A., Osório, D., Rodrigues, J., Santos, G., Porteira, A., Palma, S., Roque, A. C. & Gamboa, H., 1 Jan 2018, BIODEVICES 2018 - 11th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018. SciTePress, Vol. 1. p. 179-186 8 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Electronic nose
Volatile organic compounds
Scalability
Data acquisition
Visualization
11 Citations (Scopus)

Tilapia fish microbial spoilage monitored by a single optical gas sensor

Semeano, A. T. S., Maffei, D. F., Palma, S., Li, R. W. C., Franco, B. D. G. M., Roque, A. C. A. & Gruber, J., 1 Jul 2018, In : Food Control. 89, p. 72-76 5 p.

Research output: Contribution to journalArticle

Tilapia
tilapia (common name)
spoilage
sensors (equipment)
Fishes
2017

Cover Image, Volume 114, Number 3, March 2017

Dias, A. M. G. C. & Roque, A. C. A., 1 Mar 2017, In : Biotechnology and Bioengineering. 114, 3, p. i

Research output: Contribution to journalArticle

Scaffolds (biology)
Scaffolds
Purification
Proteins
2 Citations (Scopus)

Hybrid Magnetic-Polymeric Iron Oxide Nanoprobes for Magnetic Resonance Imaging

Roque, A. C. A. & Palma, S., Jul 2017, In : Journal Of Nanoscience And Nanotechnology. 17, 7, p. 4410-4431 22 p.

Research output: Contribution to journalReview article

Nanoparticles
Magnetic Resonance Imaging
Polymers
Ferrosoferric Oxide
Organ Specificity
1 Citation (Scopus)

Integration of molecular dynamics based predictions into the optimization of de novo protein designs: Limitations and benefits

Carvalho, H. F., Barbosa, A. J. M., Roque, A. C. A., Iranzo, O. & Branco, R. J. F., 2017, Methods in Molecular Biology. Humana Press Inc, Vol. 1529. p. 181-201 21 p. (Methods in Molecular Biology; vol. 1529).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
Molecular Dynamics Simulation
Proteins
Software
1 Citation (Scopus)

Magnetic fishing of recombinant green fluorescent proteins and tagged proteins with designed synthetic ligands

Fernandes, C. S. M., Pina, A. S., Batalha, Í. L. & Roque, A. C. A., 12 Dec 2017, In : Separation Science and Technology (Philadelphia). 52, 18, p. 2907-2915 9 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Ligands
Proteins
Bearings (structural)
Recovery
23 Citations (Scopus)

Renaissance of protein crystallization and precipitation in biopharmaceuticals purification

Dos Santos, R., Roque, A. C. A. & Carvalho, A. L., 1 Jan 2017, In : Biotechnology Advances. 35, 1, p. 41-50 10 p.

Research output: Contribution to journalReview article

Crystallization
Purification
Proteins
Pipelines
Molecules
20 Citations (Scopus)

Tunable Gas Sensing Gels by Cooperative Assembly

Hussain, A., Semeano, A. T. S., Palma, S. I. C. J., Pina, A. S., Almeida, J., Medrado, B. F., Pádua, A. C. C. S., Carvalho, A. L., Dionísio, M., Li, R. W. C., Gamboa, H., Ulijn, R. V., Gruber, J. & Roque, A. C. A., 19 Jul 2017, In : Advanced Functional Materials. 27, 27, 1700803.

Research output: Contribution to journalArticle

Gels
assembly
Gases
gels
gases
2016
4 Citations (Scopus)

Affinity adsorbents for proline-rich peptide sequences: a new role for WW domains

Dias, A. M. G. C., Garcia, R. M. N. D. S., Iranzo, O. & Roque, A. C. A., 2016, In : RCS Advances. 6, 73, p. 68979-68988 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Affitins for protein purification by affinity magnetic fishing

Fernandes, C. S. M., Garcia, R. M. N. D. S., Ottengy, S., Viecinski, A. C., Béhar, G., Mouratou, B., Pecorari, F. & Roque, A. C. A., 29 Jul 2016, In : Journal Of Chromatography A. 1457, p. 50-58 9 p.

Research output: Contribution to journalArticle

Muramidase
Proteins
Archaeal Proteins
Immunoglobulin G
Protein Engineering

An affinity triggered MRI nanoprobe for pH-dependent cell labeling

Palma, S. I. C. J., Fernandes, A. R. & Roque, A. C. A., 2016, In : RCS Advances. 6, 114, p. 113503-113512 10 p.

Research output: Contribution to journalArticle

Open Access
Nanoprobes
Labeling
Tumors
Succimer
Nanoparticles

A stimuli-responsive composite material, respective production process and application as a sensitive film

Roque, A. C. A., HUSSAIN, A., GRUBER, J. & SILVA SEMEANO, Ana, T., 18 Aug 2016, IPC No. C09K 19/ 52 A I, Patent No. WO2016128907, Priority date 10 Feb 2015, Priority No. PT20150108205

Research output: PatentInternational PCT application

Ionic Liquids
Surface-Active Agents
Volatile Organic Compounds
Liquid Crystals
Sorbitol
6 Citations (Scopus)

Mimicking nature: Phosphopeptide enrichment using combinatorial libraries of affinity ligands

Batalha, I. L., Zhou, H., Lilley, K., Lowe, C. R. & Roque, A. C. A., 29 Jul 2016, In : Journal Of Chromatography A. 1457, p. 76-87 12 p.

Research output: Contribution to journalArticle

Phosphopeptides
Ligands
Peptides
Triazines
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
4 Citations (Scopus)
Ligands
Peptides
Phosphopeptides
Atomic Spectrophotometry
Biological Products
9 Citations (Scopus)

Phosphopeptide Enrichment Using Various Magnetic Nanocomposites: An Overview

Batalha, Í. L. & Roque, A. C. A., 2016, Phospho-Proteomics. Springer, Vol. 1355. p. 193-209 17 p. ( Methods in Molecular Biology ; vol. 1355).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanocomposites
Phosphopeptides
Rare Earth Metals
Metals
Silicon Dioxide
6 Citations (Scopus)

Retroviral particles are effectively purified on an affinity matrix containing peptides selected by phage-display

Fernandes, C. S. M., Barbosa, I., Castro, R., Pina, A. S. F. P. M., Coroadinha, A. S., Barbas, A. & Roque, A. C. A., 1 Dec 2016, In : Biotechnology Journal. 11, 12, p. 1513-1524 12 p.

Research output: Contribution to journalArticle

Open Access
Bacteriophages
Peptides
Retroviridae
Particle Size
Virion
5 Citations (Scopus)

Small synthetic ligands for the enrichment of viral particles pseudotyped with amphotropic murine leukemia virus envelope

Fernandes, C. S. M., Castro, R., Coroadinha, A. S. & Roque, A. C. A., 18 Mar 2016, In : Journal Of Chromatography A. 1438, p. 160-70 11 p.

Research output: Contribution to journalArticle

Murine Leukemia Viruses
Virion
Ligands
Triazines
Genome
9 Citations (Scopus)

The future of protein scaffolds as affinity reagents for purification

Dias, A. M. G. C. & Roque, A. C. A., 29 Aug 2016, In : Biotechnology and Bioengineering. 114, 3, p. 481-491

Research output: Contribution to journalArticle

Scaffolds (biology)
Scaffolds
Purification
Ligands
Proteins
3 Citations (Scopus)

Tryptophan tags and de novo designed complementary affinity ligands for the expression and purification of recombinant proteins

Pina, A. S., Carvalho, S., Dias, A. M. G. C., Guilherme, M., Pereira, M. A. S., Caraça, L. T., Coroadinha, A. S., Lowe, C. R. & Roque, A. C. A., 11 Nov 2016, In : Journal Of Chromatography A. 1472, p. 55-65 11 p.

Research output: Contribution to journalArticle

Open Access
Recombinant Proteins
Tryptophan
Purification
Ligands
Proteins
2015
2 Citations (Scopus)

An in silico and chemical approach towards small protein production and application in phosphoproteomics

Dias, A. M. G. C., Iranzo, O. & Roque, A. C. A., 2015, In : RCS Advances. 5, 25, p. 19743-19751 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A value-added exopolysaccharide as a coating agent for MRI nanoprobes

Palma, S. I. C. J., Rodrigues, C. A. V., Carvalho, A., del Puerto Morales, M., Freitas, M. F. A. D., Fernandes, M. A. N. D. C. R., Cabral, J. M. S. & Roque, A. C. A., 14 Sep 2015, In : Nanoscale. 7, 34, p. 14272-14283 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Biobased Monoliths for Adenovirus Purification

Fernandes, C. S. M., Gonçalves, B., Sousa, M., Martins, D. L., Barroso, T., Pina, A. S., Peixoto, C., Ricardo, A. I. N. M. A. D. O. & Roque, A. C. A., 1 Apr 2015, In : Acs Applied Materials & Interfaces. 7, 12, p. 6605-6612 8 p.

Research output: Contribution to journalArticle

Biopolymers
Purification
Environmental technology
Chitosan
Macromolecular Substances
3 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Metalloproteases
metalloproteinases
Proteins
proteins
botulinum toxin
12 Citations (Scopus)

Covalent coupling of gum arabic onto superparamagnetic iron oxide nanoparticles for MRI cell labeling: physicochemical and in vitro characterization

Palma, S. I. C. J., Carvalho, A., Cavaco-Silva, J., Martins, P., Marciello, M., Fernandes, M. A. N. D. C. R., del Puerto Morales, M. & Roque, A. C. A., 2015, In : Contrast media & molecular imaging. 10, 4, p. 320-328 9 p.

Research output: Contribution to journalArticle

Dynamical Variability in the Clan MA of Metalloproteases

Carvalho, H. F., Roque, A. C. A., Iranzo, O. & Branco, R. J. F., Oct 2015, In : Protein Science. 24, p. 173-174 2 p.

Research output: Contribution to journalMeeting Abstract

37 Citations (Scopus)

Effects of phase transfer ligands on monodisperse iron oxide magnetic nanoparticles

Palma, S. I. C. J., Marciello, M., Carvalho, A., Veintemillas-Verdaguer, S., Morales, M. D. P. & Roque, A. C. A., 1 Jan 2015, In : Journal Of Colloid And Interface Science. 437, p. 147-55 9 p.

Research output: Contribution to journalArticle

Succimer
Nanoparticles
Ligands
Citric Acid
Hot Temperature

Magnetic liquid-liquid extraction for purification and partitioning of substances

Dhadge, V. L., Aires-Barros, M. R., Azevedo, A. & Roque, A. C. A., 2 Jul 2015, IPC No. B03C 1/ 30 A I, Patent No. WO2015099550, Priority date 23 Dec 2013, Priority No. PT20130107379

Research output: PatentInternational PCT application

Patents and inventions
Biomolecules
Complex Mixtures
Cell culture
Fermentation
7 Citations (Scopus)

Mild and cost-effective green fluorescent protein purification employing small synthetic ligands

Pina, A. S., Dias, A. M. G. C., Ustok, F. I., El Khoury, G., Fernandes, C. S. M., Branco, R. J. F., Lowe, C. R. & Roque, A. C. A., 30 Oct 2015, In : Journal Of Chromatography A. 1418, p. 83-93 11 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Ligands
Costs and Cost Analysis
Hydrophobic and Hydrophilic Interactions
Immunoprecipitation
2 Citations (Scopus)

Purification of human antibodies from animal cell cultures using gum arabic coated magnetic particles

Alves, B. M., Borlido, L., Rosa, S. A. S. L., Silva, M. F., Aires-Barros, M. R., Roque, A. C. A. & Azevedo, A. M., May 2015, In : Journal of Chemical Technology and Biotechnology. 90, 5, p. 838-846 9 p.

Research output: Contribution to journalArticle

2014
7 Citations (Scopus)

Affinity tags in protein purification and peptide enrichment: An overview

Pina, A. S., Batalha, I. L. & Roque, A. C. A., 17 Feb 2014, Protein Downstream Processing: Design, Development and Application of High and Low-Resolution Methods. E. Labrou, N. (ed.). Humana Press Inc., p. 147-168 22 p. (Methods in Molecular Biology; vol. 1129).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ligands
Peptides
Recombinant Fusion Proteins
Proteins
Biotechnology
15 Citations (Scopus)

An extracellular polymer at the interface of magnetic bioseparations

Dhadge, V. L., Morgado, P. I., Freitas, M. F. A. D., Reis, M. A., Azevedo, A. M., Aires-Barros, R. & Roque, A. C. A., 6 Nov 2014, In : Journal Of The Royal Society Interface. 11, 100, 20140743.

Research output: Contribution to journalArticle

Polysaccharides
Antibodies
Magnetic separation
Polymers
Immunoglobulin G
9 Citations (Scopus)

A tailor-made "tag-receptor" affinity pair for the purification of fusion proteins

Pina, A. S., Guilherme, M., Pereira, M. A. S., Fernandes, C. S. F. M., Branco, R. J. F., El Khoury, G., Lowe, C. R. & Roque, A. C. A., 7 Jul 2014, In : Chembiochem. 15, 10, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

Purification
Fusion reactions
Green Fluorescent Proteins
Ligands
Proteins
5 Citations (Scopus)

A theoretical and experimental approach toward the development of affinity adsorbents for GFP and GFP-fusion proteins purification

Fernandes, C. S. M., Pina, A. S., Dias, A. M. G. C., Branco, R. J. F. & Roque, A. C. A., 30 Sep 2014, In : Journal of Biotechnology. 186, p. 13-20 8 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Adsorbents
Purification
Fusion reactions
Ligands
13 Citations (Scopus)

Exploring the potential of magnetic antimicrobial agents for water disinfection

Pina, A. S., Batalha, I. L., Fernandes, C. S. M., Aoki, M. A. & Roque, A. C. A., 1 Dec 2014, In : Water Research. 66, p. 160-168 9 p.

Research output: Contribution to journalArticle

Antimicrobial agents
Disinfection
disinfection
Polyethylene glycols
Nanoparticles
13 Citations (Scopus)

Hybrid Monoliths for Magnetically-Driven Protein Separations

Barroso, T., Casimiro, T., Ferraria, A. M., Mattioli, F., Ricardo, A. I. N. M. A. D. O. & Roque, A. C. A., 23 Jul 2014, In : Advanced Functional Materials. 24, 28, p. 4528-4541 14 p.

Research output: Contribution to journalArticle