• 1323 Citations
  • 17 h-Index
20092020

Research output per year

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Research Output at NOVA

  • 1323 Citations
  • 17 h-Index
  • 40 Article
  • 1 Chapter
  • 1 Meeting Abstract
  • 1 Review article
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Article
2020
Open Access
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3 Downloads (Pure)
2019

Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Figueira, I., Tavares, L., Jardim, C., Costa, I., Terrasso, A. P., Almeida, A. F., Govers, C., Mes, J. J., Gardner, R., Becker, J. D., McDougall, G. J., Stewart, D., Filipe, A., Kim, K. S., Brites, D., Brito, C., Brito, M. A. & Santos, C. N., 1 Feb 2019, In : European Journal of Nutrition. 58, 1, p. 113-130 18 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization

Torán, J. L., López, J. A., Gomes-Alves, P., Aguilar, S., Torroja, C., Trevisan-Herraz, M., Moscoso, I., Sebastião, M. J., Serra, M., Brito, C., Cruz, F. M., Sepúlveda, J. C., Abad, J. L., Galán-Arriola, C., Ibanez, B., Martínez, F., Fernández, M. E., Fernández-Aviles, F., Palacios, I., R-Borlado, L. & 3 others, Vázquez, J., Alves, P. M. & Bernad, A., 1 Dec 2019, In : Scientific Reports. 9, 1, 4647.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Evaluation of AAV-mediated delivery of shRNA to target basal-like breast cancer genetic vulnerabilities

Pinto, C., Silva, G., Ribeiro, A. S., Oliveira, M., Garrido, M., Bandeira, V. S., Nascimento, A., Coroadinha, A. S., Peixoto, C., Barbas, A., Paredes, J., Brito, C. & Alves, P. M., 20 Jul 2019, In : Journal of Biotechnology. 300, p. 70-77 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Flexible 3d cell-based platforms for the discovery and profiling of novel drugs targeting plasmodium hepatic infection

Arez, F., Rebelo, S. P., Fontinha, D., Simaõ, D., Martins, T. R., MacHado, M., Fischli, C., Oeuvray, C., Badolo, L., Carrondo, M. J. T., Rottmann, M., Spangenberg, T., Brito, C., Greco, B., Prudêncio, M. & Alves, P. M., 8 Nov 2019, In : ACS Infectious Diseases . 5, 11, p. 1831-1842 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Scalable culture strategies for the expansion of patient-derived cancer stem cell lines

Serra, A. T., Serra, M., Silva, A. C. S. F. D., Brckalo, T., Seshire, A., Brito, C., Wolf, M. & Alves, P. M., 1 Jan 2019, In : Stem Cells International. 2019, 8347595.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
1 Downloads (Pure)
2018

3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment

Rebelo, S. P., Pinto, C., Martins, T. R., Harrer, N., Estrada, M. F., Loza-Alvarez, P., Cabeçadas, J., Alves, P. M., Gualda, E. J., Sommergruber, W. & Brito, C., 1 May 2018, In : Biomaterials. 163, p. 185-197 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons

Bayó-Puxan, N., Terrasso, A. P., Creyssels, S., Simão, D., Begon-Pescia, C., Lavigne, M., Salinas, S., Bernex, F., Bosch, A., Kalatzis, V., Levade, T., Cuervo, A. M., Lory, P., Consiglio, A., Brito, C. & Kremer, E. J., 1 Dec 2018, In : Scientific Reports. 8, 1, 16644.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
12 Downloads (Pure)

Mucins and truncated O-glycans unveil phenotypic discrepancies between serous ovarian cancer cell lines and primary tumours

Coelho, R., Marcos-Silva, L., Mendes, N., Pereira, D., Brito, C., Jacob, F., Steentoft, C., Mandel, U., Clausen, H., David, L. & Ricardo, S., 13 Jul 2018, In : International Journal of Molecular Sciences. 19, 7, 2045.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)

Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer

Silva, I. N., Estrada, M. F., V. Pereira, C., da Silva, A. B., Bronze, M. R., Alves, P. M., Duarte, C. M. M., Brito, C. & Serra, A. T., 17 Feb 2018, In : Nutrition and Cancer. 70, 2, p. 257-266 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation

Simão, D., Silva, M. M., Terrasso, A. P., Arez, F., Sousa, M. F. Q., Mehrjardi, N. Z., Šarić, T., Gomes-Alves, P., Raimundo, N., Alves, P. M. & Brito, C., 14 Aug 2018, In : Stem Cell Reports. 11, 2, p. 552-564 13 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
2017

Data descriptor: Protocols and characterization data for 2d, 3d, and slice-based tumor models from the predect project

De Hoogt, R., Estrada, M. F., Vidic, S., Davies, E. J., Osswald, A., Barbier, M., Santo, V. E., Gjerde, K., Van Zoggel, H. J. A. A., Blom, S., Dong, M., Närhi, K., Boghaert, E., Brito, C., Chong, Y., Sommergruber, W., Van Der Kuip, H., Van Weerden, W. M., Verschuren, E. W., Hickman, J. & 1 others, Graeser, R., 21 Nov 2017, In : Scientific Data. 4, 170170.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

Santo, V. E., Rebelo, S. P., Estrada, M. F., Alves, P. M., Boghaert, E. & Brito, C., 1 Jan 2017, In : Biotechnology Journal. 12, 1, 1600505.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Human neuron-astrocyte 3D co-culture-based assay for evaluation of neuroprotective compounds

Terrasso, A. P., Silva, A. C., Filipe, A., Pedroso, P., Ferreira, A. L., Alves, P. M. & Brito, C., 1 Jan 2017, In : Journal of Pharmacological and Toxicological Methods. 83, p. 72-79 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Polyphenols journey through blood-brain barrier towards neuronal protection

Figueira, I., Garcia, G., Pimpão, R. C., Terrasso, A. P., Costa, I., Almeida, A. F., Tavares, L., Pais, T. F., Ventura, M. R., Filipe, A., McDougall, G. J., Stewart, D., Kim, K. S., Palmela, I., Brites, D., Brito, M. A., Santos, C. N. & Brito, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 11456.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis

Sá, J. V., Kleiderman, S., Brito, C., Sonnewald, U., Leist, M., Teixeira, A. P. & Alves, P. M., 1 Jan 2017, In : Neurochemical Research. 42, 1, p. 244-253 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The Volume of Three-Dimensional Cultures of Cancer Cells In Vitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors

Boghaert, E. R., Lu, X., Hessler, P. E., McGonigal, T. P., Oleksijew, A., Mitten, M. J., Foster-Duke, K., Hickson, J. A., Santo, V. E., Brito, C., Uziel, T. & Vaidya, K. S., 1 Sep 2017, In : Neoplasia (United States). 19, 9, p. 695-706 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
34 Citations (Scopus)
2016

Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models

Santo, V. E., Estrada, M. F., Rebelo, S. P., Abreu, S., Silva, I., Pinto, C., Veloso, S. C., Serra, A. T., Boghaert, E., Alves, P. M. & Brito, C., 10 Mar 2016, In : Journal of Biotechnology. 221, p. 118-129 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Stock, K., Estrada, M. F., Vidic, S., Gjerde, K., Rudisch, A., Santo, V. E., Barbier, M., Blom, S., Arundkar, S. C., Selvam, I., Osswald, A., Stein, Y., Gruenewald, S., Brito, C., Van Weerden, W., Rotter, V., Boghaert, E., Oren, M., Sommergruber, W., Chong, Y. & 2 others, de Hoogt, R. & Graeser, R., 1 Jul 2016, In : Scientific Reports. 6, 28951.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Conversion of Nonproliferating Astrocytes into Neurogenic Neural Stem Cells: Control by FGF2 and Interferon-γ

Kleiderman, S., Gutbier, S., Ugur Tufekci, K., Ortega, F., Sá, J. V., Teixeira, A. M., Montes, A. C., Glaab, E., Berninger, B., Alves, P. M. & Leist, M., 1 Dec 2016, In : Stem Cells. 34, 12, p. 2861-2874 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells

Kleiderman, S., Sá, J. V., Teixeira, A. P., Brito, C., Gutbier, S., Evje, L. G., Hadera, M. G., Glaab, E., Henry, M., Sachinidis, A., Alves, P. M., Sonnewald, U. & Leist, M., 1 May 2016, In : Glia. 64, 5, p. 695-715 21 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Functional metabolic interactions of human neuron-astrocyte 3D in vitro networks

Simão, D., Terrasso, A. P., Teixeira, A. P., Brito, C., Sonnewald, U. & Alves, P. M., 13 Sep 2016, In : Scientific Reports. 6, 33285.

Research output: Contribution to journalArticle

7 Citations (Scopus)

In vitro expansion of human cardiac progenitor cells: Exploring 'omics tools for characterization of cell-based allogeneic products

Gomes-Alves, P., Serra, M., Brito, C., Ricardo, C. P., Cunha, J. R., Sousa, M. F., Teresa Blazquez-Sanchez, M., Bernad, A., Carrondo, M. J. T., Rodriguez-Borlado, L. & Alves, P. M., 1 May 2016, In : Translational Research. 171, p. 96-110 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression

Estrada, M. F., Rebelo, S. P., Davies, E. J., Pinto, M. T., Pereira, H., Santo, V. E., Smalley, M. J., Barry, S. T., Gualda, E. J., Alves, P. M., Anderson, E. & Brito, C., 1 Feb 2016, In : Biomaterials. 78, p. 50-61 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2015

A multi-organ chip co-culture of neuro spheres and liver equivalents for long-term substance testing

Materne, E-M., Ramme, A. P., Terrasso, A. P., Serra, M., Alves, P. M., Montes, A. C., Sakharov, D. A., Tonevitsky, A. G., Lauster, R. & Marx, U., 10 Jul 2015, In : Journal of Biotechnology. 205, p. 36-46 11 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Exploring analytical proteomics platforms toward the definition of human cardiac stem cells receptome

Gomes-Alves, P., Serra, M., Montes, A. C., R.-Borlado, L., López, J. A., Vázquez, J., Carrondo, M. J. T., Bernad, A. & Alves, P. M., 1 Apr 2015, In : Proteomics. 15, 7, p. 1332-1337 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Novel scalable 3D cell based model for in vitro neurotoxicity testing: Combining human differentiated neurospheres with gene expression and functional endpoints

Terrasso, A. P., Pinto, C., Serra, M., Filipe, A., Almeida, S., Ferreira, A. L., Pedroso, P., Montes, A. C. & Alves, P. M., 1 Jul 2015, In : Journal of Biotechnology. 205, p. 82-92 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

SPIM-fluid: Open source light-sheet based platform for high-throughput imaging

Gualda, E. J., Pereira, H., Vale, T., Estrada, M. F., Montes, A. C. & Moreno, N., 19 Oct 2015, In : Biomedical Optics Express. 6, 11, p. 4447-4456 10 p., 245811.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups

Piersanti, S., Burla, R., Licursi, V., Montes, A. C., La Torre, M., Alves, P. M., Simao, D., Mottini, C., Salinas, S., Negri, R., Tagliafico, E., Kremer, E. J. & Saggio, I., 24 Jul 2015, In : PlosOne. 10, 7, 17 p., 0133607.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes

Correia, C., Serra, M., Espinha, N., Sousa, M., Montes, A. C., Burkert, K., Zheng, Y., Hescheler, J., Carrondo, M. J. T., Šarić, T. & Alves, P. M., 2014, In : Stem Cell Reviews and Reports. 10, 6, p. 786-801 16 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Imaging of human differentiated 3D neural aggregates using light sheet fluorescence microscopy

Gualda, E. J., Simão, D., Pinto, C., Alves, P. M. & Brito, C., 6 Aug 2014, In : Frontiers in Cellular Neuroscience. 8, AUG, 221.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012
Open Access
39 Citations (Scopus)
Open Access
116 Citations (Scopus)

Process engineering of human pluripotent stem cells for clinical application

Alves, P. M. & Montes, A. C., 1 Jan 2012, In : Trends In Biotechnology. 30, 6, p. 350-359

Research output: Contribution to journalArticle

Open Access
179 Citations (Scopus)
13 Citations (Scopus)

Surface-based cryopreservation strategies for human embryonic stem cells: A comparative study

Alves, P. M. & Montes, A. C., 1 Jan 2012, In : Biotechnology Progress. 28, 4, p. 1079-1087

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2011
117 Citations (Scopus)
2009

Integrating human stem cell expansion and neuronal differentiation in bioreactors

Alves, P. M. & Montes, A. C., 1 Jan 2009, In : Bmc Biotechnology. 9, NA, p. art82

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)
Open Access
7 Citations (Scopus)