Research Output 1993 2019

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2019
1 Citation (Scopus)
3 Downloads (Pure)

Hydrogen sulfide oxidation: Adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia

Malagrinò, F., Zuhra, K., Mascolo, L., Mastronicola, D., Vicente, J. B., Forte, E. & Giuffrè, A., 1 Jan 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 8102936.

Research output: Contribution to journalArticle

Open Access
File
Hydrogen Sulfide
Mitochondria
Sulfides
sulfide quinone reductase
Colorectal Neoplasms
1 Citation (Scopus)
1 Downloads (Pure)

Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods

Zuhra, K., Sousa, P. M. F., Paulini, G., Lemos, A. R., Kalme, Z., Bisenieks, I., Bisenieks, E., Vigante, B., Duburs, G., Bandeiras, T. M., Saso, L., Giuffrè, A. & Vicente, J. B., 1 Dec 2019, In : Scientific Reports. 9, 1, 684.

Research output: Contribution to journalArticle

Open Access
File
Hydrogen Sulfide
Cystathionine
Lyases
Enzymes
Fluorometry
2018
14 Citations (Scopus)

3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment

Rebelo, S. P., Pinto, C., Martins, T. R., Harrer, N., Estrada, M. F., Loza-Alvarez, P., Cabeçadas, J., Alves, P. M., Gualda, E. J., Sommergruber, W. & Brito, C., 1 May 2018, In : Biomaterials. 163, p. 185-197 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Macrophages
Cell culture
Plasticity
Tumors
13 Citations (Scopus)

3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes

Correia, C., Koshkin, A., Duarte, P., Hu, D., Carido, M., Sebastião, M. J., Gomes-Alves, P., Elliott, D. A., Domian, I. J., Teixeira, A. P., Alves, P. M. & Serra, M., 1 Mar 2018, In : Biotechnology and Bioengineering. 115, 3, p. 630-644 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Stem cells
Cell culture
Cardiac Myocytes
3 Citations (Scopus)
7 Downloads (Pure)

A detection and quantification label-free tool to speed up downstream processing of model mucins

Carvalho, S. B., Moreira, A. S., Gomes, J., Carrondo, M. J. T., Thornton, D. J., Alves, P. M., Costa, J. & Peixoto, C., 1 Jan 2018, In : PLoS ONE. 13, 1, e0190974.

Research output: Contribution to journalArticle

Open Access
File
mucins
Mucins
Labels
lectins
Processing
4 Citations (Scopus)

Characterization of sweat induced with pilocarpine, physical exercise, and collected passively by metabolomic analysis

Souza, S. L., Graça, G. & Oliva, A., 1 May 2018, In : Skin Research And Technology. 24, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Pilocarpine
Metabolomics
Sweat
Exercise
Amino Acids
2 Citations (Scopus)
1 Downloads (Pure)

Clinical-grade oncolytic adenovirus purification using polysorbate 20 as an alternative for cell lysis

Moleirinho, M. G., Rosa, S., Carrondo, M. J. T., Silva, R. J. S., Hagner-McWhirter, Å., Ahlén, G., Lundgren, M., Alves, P. M. & Peixoto, C., 1 Jan 2018, In : Current Gene Therapy. 18, 6, p. 366-374 9 p.

Research output: Contribution to journalArticle

Open Access
File
Polysorbates
Octoxynol
Adenoviridae
Clinical Trials, Phase I
Surface-Active Agents
6 Citations (Scopus)

Combining stable insect cell lines with baculovirus-mediated expression for multi-HA influenza VLP production

Sequeira, D. P., Correia, R., Carrondo, M. J. T., Roldão, A., Teixeira, A. P. & Alves, P. M., 24 May 2018, In : Vaccine. 36, 22(SI), p. 3112-3123 12 p.

Research output: Contribution to journalArticle

virus-like particles
Baculoviridae
Hemagglutinins
hemagglutinins
Orthomyxoviridae
1 Citation (Scopus)

Flexible pseudotyping of retrovirus using recombinase-mediated cassette exchange

Soares, H. R., Almeida, A. I., Tomás, H. A., Alves, P. M. & Coroadinha, A. S., 1 Apr 2018, In : Biotechnology Letters. 40, 4, p. 633-639 7 p.

Research output: Contribution to journalArticle

Recombinases
Retroviridae
Productivity
Cells
Proteins

Full-length human CCBE1 production and purification: leveraging bioprocess development for high quality glycosylation attributes and functionality

Silva, M. M., Gomes-Alves, P., Rosa, S., Simão, D., Inácio, J. M., Peixoto, C., Serra, M., Belo, J. A. & Alves, P. M., 10 Nov 2018, In : Journal of Biotechnology. 285, p. 6-14 9 p.

Research output: Contribution to journalArticle

Glycosylation
Epidermal Growth Factor
Purification
Calcium
Proteins
4 Citations (Scopus)

Human cardiac stem cells inhibit lymphocyte proliferation through paracrine mechanisms that correlate with indoleamine 2,3-dioxygenase induction and activity

Sebastião, M. J., Menta, R., Serra, M., Palacios, I., Alves, P. M., Sanchez, B., Delarosa, O., Dalemans, W., Lombardo, E. & Gomes-Alves, P., 25 Oct 2018, In : Stem Cell Research and Therapy. 9, 1, 290.

Research output: Contribution to journalArticle

Open Access
File
Indoleamine-Pyrrole 2,3,-Dioxygenase
Lymphocytes
Stem cells
Stem Cells
T-cells
1 Citation (Scopus)

Impact of hydrodynamics on iPSC-derived cardiomyocyte differentiation processes

Samaras, J. J., Abecasis, B., Serra, M. M., Ducci, A. & Micheletti, M., 10 Dec 2018, In : Journal of Biotechnology. 287, p. 18-27 10 p.

Research output: Contribution to journalArticle

Hydrodynamics
Cardiac Myocytes
Tuning
Frequency modulation
Fourier Analysis
2 Citations (Scopus)

In vivo persistence of chimeric virus after substitution of the kaposi's sarcoma-associated herpesvirus LANA DNA binding domain with that of murid herpesvirus 4

De Miranda, M. P., Quendera, A. P., McVey, C. E., Kaye, K. M. & Simas, J. P., 1 Nov 2018, In : Journal of Virology. 92, 21, e01251.

Research output: Contribution to journalArticle

Murid herpesvirus 4
Rhadinovirus
Human herpesvirus 8
Human Herpesvirus 8
DNA-binding domains
8 Citations (Scopus)

Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer

Silva, I. N., Estrada, M. F., V. Pereira, C., da Silva, A. B., Bronze, M. R., Alves, P. M., Duarte, C. M. M., Brito, C. & Serra, A. T., 17 Feb 2018, In : Nutrition and Cancer. 70, 2, p. 257-266 10 p.

Research output: Contribution to journalArticle

Flavones
Colorectal Neoplasms
Cell Proliferation
Supercritical Fluid Chromatography
Tumor Microenvironment
10 Citations (Scopus)

Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation

Simão, D., Silva, M. M., Terrasso, A. P., Arez, F., Sousa, M. F. Q., Mehrjardi, N. Z., Šarić, T., Gomes-Alves, P., Raimundo, N., Alves, P. M. & Brito, C., 14 Aug 2018, In : Stem Cell Reports. 11, 2, p. 552-564 13 p.

Research output: Contribution to journalArticle

Open Access
File
Extracellular Matrix
Brain
Cell membranes
Stem cells
Cell culture
1 Citation (Scopus)

Syntheses of the plant auxin conjugate 2-O-(indole-3-acetyl)-myo-inositol IAInos

Silva, S., Ascenso, O. S., Lourenço, E. C., Archer, M., Maycock, C. D. & Ventura, M. R., 1 Jan 2018, In : Organic and Biomolecular Chemistry. 16, 38, p. 6860-6864 5 p.

Research output: Contribution to journalArticle

auxins
inositols
Indoleacetic Acids
indoles
Inositol
2 Citations (Scopus)

Unveiling Human Cardiac Fibroblast Membrane Proteome

Sebastião, M. J., Pereira, R., Serra, M., Gomes-Alves, P. & Alves, P. M., 1 Jul 2018, In : Proteomics. 18, 13, 1700446.

Research output: Contribution to journalArticle

Proteome
Fibroblasts
Membranes
Membrane Proteins
Stem cells
2 Downloads (Pure)

X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action

Silva, S. T. N., Brito, J. A., Arranz, R., Sorzano, C. Ó. S., Ebel, C., Doutch, J., Tully, M. D., Carazo, J. M., Carrascosa, J. L., Matias, P. M. & Bandeiras, T. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 13726.

Research output: Contribution to journalArticle

Open Access
File
Adenosine Triphosphate
X-Rays
Cryoelectron Microscopy
Protein Conformation
Proteins
1997
18 Citations (Scopus)

Crystal structure of cytochrome c' from Rhodocyclus gelatinosus and comparison with other cytochromes c'

Archer, M., Banci, L., Dikaya, E. & Romão, M. J., 1 Oct 1997, In : Journal of Biological Inorganic Chemistry. 2, 5, p. 611-622 12 p.

Research output: Contribution to journalArticle

Rhodocyclaceae
Cytochromes c'
Crystal structure
Bacteria
Cytochrome c Group
1996
237 Citations (Scopus)

A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes

Huber, R., Hof, P., Duarte, R. O., Moura, J. J. G., Moura, I., Liu, M. Y., LeGall, J., Hille, R., Archer, M. & Romão, M. J., 20 Aug 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 17, p. 8846-8851 6 p.

Research output: Contribution to journalArticle

Open Access
File
Molybdenum
Xanthine Oxidase
Aldehyde Oxidoreductases
Water
Desulfovibrio gigas
1995
8 Citations (Scopus)

Cytochrome c6 from the green alga Monoraphidium braunii. Crystallization and preliminary diffraction studies

Frazão, C., Dias, J. M., Matias, P. M., Romão, M. J., Carrondo, M. A., Hervas, M., Navarro, J. A., De La Rosa, M. & Sheldrick, G. M., 1 Jan 1995, In : Acta Crystallographica - Section D Biological Crystallography. 51, 2, p. 232-234 3 p.

Research output: Contribution to journalArticle

1993
23 Citations (Scopus)
3 Downloads (Pure)
Open Access
File
Aldehyde Oxidoreductases
Desulfovibrio gigas
Pterins
Molybdenum
2-Propanol