Centro de Investigação em Genética Molecular Humana (CIGMH)

  • Portugal

Research Output 1994 2017

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3 Citations (Scopus)

Unspliced Precursors of NMD-Sensitive β-Globin Transcripts Exhibit Decreased Steady-State Levels in Erythroid Cells.

Morgado, A., Almeida, F., Teixeira, A., Silva, A. L. & Romão, L., 1 Jan 2012, In : PLoS ONE. 7, 6, p. Online

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Erythroid Cells
Globins
Nonsense Codon
stop codon

The chemistry and biology of gold nanoparticle-mediated photothermal therapy: promises and challenges

Baptista, P. M. R. V., 1 Jan 2013, In : Nano LIFE. 03, 03, p. nr. 1330001

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Tc-99m-Tricarbonyl Complexes Functionalized with Anthracenyl Fragments: Synthesis, Characterization, and Evaluation of Their Radiotoxic Effects in Murine Melanoma Cells

Vitor, RF., Esteves, T., Marques, F., Raposinho, P., Paulo, A., Rodrigues, A. S., Rueff, J., Casimiro, S., Costa, L. & Santos, I., 1 Oct 2009, In : Cancer biotherapy & radiopharmaceuticals. 24, 5, p. 551-563 13 p.

Research output: Contribution to journalArticle

Melanoma
Diamines
DNA
Electrons
Ligands
12 Citations (Scopus)
Oxyquinoline
Chromophores
chromophores
Metal ions
metal ions
22 Citations (Scopus)

Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands

Silva, F., Marques, F., Santos, I. C., Paulo, A., Rodrigues, A. S., Rueff, J. & Santos, I., 1 Jan 2010, In : Journal of Inorganic Biochemistry. 104, 5, p. 523-532

Research output: Contribution to journalArticle

56 Citations (Scopus)

Star-shaped magnetite@gold nanoparticles for protein magnetic separation and SERS detection

Quaresma, P., Osório, I., Dória, G., Carvalho, P. A., Pereira, A., Langer, J., Araújo, J. P., Pastoriza-Santos, I., Liz-Marzán, L. M., Franco, R., Baptista, P. & Pereira, E., 2014, In : RCS Advances. 4, 8, p. 3659-3667 9 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Magnetic separation
Magnetite
Gold
Stars
5 Citations (Scopus)

Single Nucleotide Polymorphism Detection Using Gold Nanoprobes and Bio-Microfluidic Platform With Embedded Microlenses

Bernacka-Wojcik, I., Aguas, H., Carlos, F. F., Lopes, P., Wojcik, P. J., Costa, M. N., Veigas, B., Igreja, R., Fortunato, E., Baptista, P. & Martins, R., 10 Mar 2015, In : Biotechnology and Bioengineering. 112, 6, p. 1210-1219 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1 Downloads (Pure)

Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity

Pereira, F. J. C., Teixeira, A. R. S., Kong, J., Barbosa, C., Silva, A. L., Marques-Ramos, A., Liebhaber, S. A. & Romão, L., 23 May 2015, In : Nucleic Acids Research. 43, 13, p. 6528-6544 17 p.

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Nonsense Codon
Messenger RNA
Globins
Open Reading Frames
20 Citations (Scopus)

Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide

Fernandes, A. S., Gaspar, J., Cabral, M. F., Rueff, J., Castro, M., Batinic-Haberle, I., Costa, J. & Oliveira, N. G., 19 Mar 2010, In : Free Radical Research. 44, 4, p. 430-440 11 p.

Research output: Contribution to journalArticle

tert-Butylhydroperoxide
Cells
Wounds and Injuries
Glutathione
Assays
11 Citations (Scopus)

Prognostic value of microRNA-203a expression in breast cancer

Gomes, B. C., Martins, M., Lopes, P., Morujão, I., Oliveira, M., Araújo, A., Rueff, J. & Rodrigues, AS., 1 Sep 2016, In : Oncology Reports. 36, 3, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Breast Neoplasms
Neoplasms
Lobular Carcinoma
Carcinoma, Intraductal, Noninfiltrating

Preface

Rueff, J. & Rodrigues, AS., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. v-vii

Research output: Contribution to journalArticle

Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites

Sequeira, I. J. D. S., Mexia, J. T. P. N., Santiago, J., Mamede, R., Silva, E., Santos, J., Faria, D., Rueff, J. & Brás, A., 1 Jan 2013, In : Open Journal of Genetics. 3, NA, p. 8-13

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)

Polyurea dendrimer for efficient cytosolic siRNA delivery

Cidade, M. T. V. & Baptista, P., 1 Jan 2014, In : RSC ADVANCES. 4, 97, p. 54872-54878

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
Photochemical reactions
Quantum yield
photochemical reactions
esters
phosphates
24 Citations (Scopus)
Open Access
3 Citations (Scopus)

Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

Martins, P., Rosa, D., Fernandes, A. R. & Baptista, P., Jan 2013, In : Recent Patents on Nanomedicine. 3, 2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Nanomedicine
Medical nanotechnology
Patents
Drug Delivery Systems
Drug delivery
Open Access
14 Citations (Scopus)
Myristica fragrans
K562 Cells
DNA Damage
Leukemia
Down-Regulation
6 Citations (Scopus)

Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice

Louro, H., Pinheiro, I., Costa, P., Sousa, C., Dias, A., Boavida, M. G. & Silva, M. J., 2 Apr 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 640, 1-2, p. 82-88 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Testis
Point Mutation
Lac Operon
Sequence Deletion
6 Citations (Scopus)
Nitrosation
Gastric Juice
Glycine
Chlorides
Stomach
19 Citations (Scopus)

Mutagenic activity of cisplatin in the lacZ plasmid-based transgenic mouse model

Louro, H., Silva, M. J. & Boavida, M. G., 1 Dec 2002, In : Environmental And Molecular Mutagenesis. 40, 4, p. 283-291 9 p.

Research output: Contribution to journalArticle

plasmid
Cisplatin
Transgenic Mice
mutation
Plasmids

Multifunctional gold nanoparticles for gene silencing

Baptista, P. M. R. V., 1 Jan 2012, In : Abstracts Of Papers Of The American Chemical Society. 243, NA, p. -

Research output: Contribution to journalArticle

14 Citations (Scopus)

MicroRNAs and Cancer Drug Resistance

Gomes, B. C., Rueff, J. & Rodrigues, A. S., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. 137-62 26 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Small Untranslated RNA
Neoplasms
Epithelial-Mesenchymal Transition
15 Citations (Scopus)
57 Citations (Scopus)

Macrocyclic copper(II) complexes: Superoxide scavenging activity, structural studies and cytotoxicity evaluation

Fernandes, A. S., Gaspar, J., Cabral, M. F., Caneiras, C., Guedes, R., Rueff, J., Castro, M., Costa, J. & Oliveira, N. G., 1 May 2007, In : Journal of Inorganic Biochemistry. 101, 5, p. 849-858 10 p.

Research output: Contribution to journalArticle

Scavenging
Cytotoxicity
Superoxides
Copper
Assays
26 Citations (Scopus)
Open Access
Ions
DNA
Point-of-Care Systems
Equipment and Supplies
Proto-Oncogenes
91 Citations (Scopus)
Open Access
1 Citation (Scopus)
Human Genome
Viruses
Genes
HIV
Virus Integration
12 Citations (Scopus)

Instability of the human cytochrome P450 reductase A287P variant is the major contributor to its Antley-Bixler syndrome-like phenotype

McCammon, K. M., Panda, S. P., Xia, C., Kim, J. J. P., Moutinho, D., Kranendonk, M., Auchus, R. J., Lafer, E. M., Ghosh, D., Martasek, P., Kar, R., Masters, B. S. & Roman, L. J., 23 Sep 2016, In : Journal of Biological Chemistry. 291, 39, p. 20487-20502 16 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
NADPH-Ferrihemoprotein Reductase
Oxidoreductases
Differential Scanning Calorimetry
Proteins
26 Citations (Scopus)
RNA Stability
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Genes
Therapeutics
20 Citations (Scopus)

Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies

Luis, DV., Silva, J., Tomaz, AI., de Almeida, RFM., Larguinho, M., Baptista, P. V., Martins, LMDRS., Silva, TFS., Borralho, PM., Rodrigues, CMP., Rodrigues, A. S., Pombeiro, AJL. & Fernandes, A. R., 1 Jan 2014, In : Journal Of Biological Inorganic Chemistry. 19, 6, p. 787-803

Research output: Contribution to journalArticle

10 Citations (Scopus)
Sister Chromatid Exchange
Acrylamide
DNA Repair
Lymphocytes
Genes
24 Citations (Scopus)

Increased levels of sister chromatid exchanges in military aircraft pilots

Silva, M. J., Carothers, A., Castelo Branco, N., Dias, A. & Boavida, M. G., 26 Apr 1999, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 441, 1, p. 129-134 6 p.

Research output: Contribution to journalArticle

Sister Chromatid Exchange
Aircraft
Vibration
Noise
Cell Count
4 Citations (Scopus)
Nevirapine
Metabolites
Liver
Skin
Mutagenicity Tests
4 Citations (Scopus)

Human exposure to indoor radon: a survey in the region of Guarda, Portugal

Louro, A., Peralta, L., Soares, S., Pereira, A., Cunha, G., Belchior, A., Ferreira, L., Gil, OM., Louro, H., Pinto, P., Rodrigues, A. S., Silva, MJ. & Teles, P., 2013, In : Radiation Protection Dosimetry. 154, 2, p. 237-244

Research output: Contribution to journalArticle

Portugal
Radon
radon
Gases
tobacco
39 Citations (Scopus)
10 Downloads (Pure)

Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

Marohnic, C. C., Panda, S. P., McCammon, K. M., Rueff, J., Masters, B. S. S. & Kranendonk, M., 1 Jan 2010, In : Drug Metabolism And Disposition. 38, 2, p. 332-340

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)

Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis

Pedrosa, P., Veigas, B., Machado, D., Couto, I., Viveiros, M. & Baptista, P., May 2014, In : Tuberculosis. 94, 3, p. 332-337 6 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Gold
Rifampin
Mycobacterium tuberculosis
Genes
9 Citations (Scopus)

Gold nanoparticle-siRNA mediated oncogene knockdown at RNA and protein level, with associated gene effects

Child, H. W., Hernandez, Y., Conde, J., Mullin, M., Baptista, P., Maria de la Fuente, J. & Berry, C. C., 2015, In : Nanomedicine. 10, 16, p. 2513-2525 13 p.

Research output: Contribution to journalArticle

340 Citations (Scopus)

Gold nanoparticles for the development of clinical diagnosis methods

Baptista, P. M. R. V. & Franco, R., 1 Jan 2008, In : Analytical and Bioanalytical Chemistry. 391, 3, p. 943-950

Research output: Contribution to journalArticle

Open Access
340 Citations (Scopus)

Gold nanoparticles for the development of clinical diagnosis methods

Baptista, P. M. R. V. & Franco, R., 1 Jan 2008, In : Analytical and Bioanalytical Chemistry. 391, 3, p. 943-950

Research output: Contribution to journalArticle

Open Access
43 Citations (Scopus)
Open Access
Immunoassay
Gold
Nanoparticles
Malaria
Fluorescence
70 Citations (Scopus)
Open Access
56 Citations (Scopus)
Open Access
116 Citations (Scopus)

Gold and silver nanoparticles for clinical diagnostics - From genomics to proteomics.

Baptista, P. M. R. V., 1 Jan 2011, In : Journal of Proteomics. 75, NA, p. 2811-23

Research output: Contribution to journalArticle

Open Access
Nanotechnology
Genomics
Silver
Gold
Proteomics
5 Citations (Scopus)