Centro de Investigação em Genética Molecular Humana (CIGMH)

  • Portugal

Research Output 1994 2017

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13 Citations (Scopus)

Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer

Cristóvão, L., Lechner, M. C., Fidalgo, P., Leitão, C. N., Mira, F. C. & Rueff, J., 1 Jan 1998, In : British Journal of Cancer. 77, 10, p. 1628-1632 5 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Colonic Neoplasms
Adenomatous Polyposis Coli
NAD
Radiation
13 Citations (Scopus)

ACMA (9-amino-6-chloro-2-methoxy acridine) forms three complexes in the presence of DNA

Busto, N., García, B., Leal, J. M., Gaspar, J. F., Martins, C., Boggioni, A. & Secco, F., 21 Nov 2011, In : Physical Chemistry Chemical Physics. 13, 43, p. 19534-19545 12 p.

Research output: Contribution to journalArticle

Acridines
deoxyribonucleic acid
DNA
kinetics
dyes
90 Citations (Scopus)
Open Access
19 Citations (Scopus)

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Human Activities
Cytochrome P-450 Enzyme System
39 Citations (Scopus)
Open Access
Nucleic acid sequences
Nanocrystalline silicon
Amorphous silicon
Biosensors
Gold
6 Citations (Scopus)

Analysis of Pelagia noctiluca proteome Reveals a Red Fluorescent Protein, a Zinc Metalloproteinase and a Peroxiredoxin

Frazao, B., Campos, A., Osorio, H., Thomas, B., Leandro, S., Teixeira, A., Vasconcelos, V. & Antunes, A., Apr 2017, In : Protein Journal. 36, 2, p. 77-97 11 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Antibody-drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics

Conde, J., Bao, C., Cui, D., Baptista, P. & Tian, F., 10 Jun 2014, In : Journal Of Controlled Release. 183, p. 87-93 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

A promising road with challenges: where are gold nanoparticles in translational research?

Bao, C., Conde, J., Polo, E., del Pino, P., Moros, M., Baptista, P., Grazu, V., Cui, D. & de la Fuente, J. M., 2014, In : Nanomedicine. 9, 15, p. 2353-2370 18 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
Open Access
7 Citations (Scopus)

Characterization of genomic single nucleotide polymorphism via colorimetric detection using a single gold nanoprobe

Carlos, F. F., Flores, O., Doria, G. & Baptista, P., 15 Nov 2014, In : Analytical Biochemistry. 465, p. 1-5 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Chitosan mouthwash: Toxicity and in vivo validation

Costa, E. M., Silva, S., Costa, M. R., Pereira, M., Campos, D. A., Odila, J., Madureira, A. R., Cardelle-Cobas, A., Tavaria, F. K., Rodrigues, A. S. & Pintado, M. M., 2014, In : Carbohydrate Polymers. 111, NA, p. 385-392 8 p.

Research output: Contribution to journalArticle

Mouthwashes
Chitosan
Toxicity
Assays
Cytotoxicity
86 Citations (Scopus)

Colorimetric detection of eukaryotic gene expression with DNA-derivatized gold nanoparticles

Baptista, P. M. R. V., Dória, G., Henriques, D., Pereira, E. & Franco, R., 1 Jan 2005, In : Journal of Biotechnology. 119, 2, p. 111-7 7 p.

Research output: Contribution to journalArticle

Open Access
RNA
Gene expression
Gold
Nanoparticles
DNA
3 Citations (Scopus)

Combined molecular diagnosis of b-cell lymphomas with t(11;14)(q13;q32) or t(14;18)(q32;q21) using multiplex- and long distance inverse-polymerase chain reaction

Vieira, L., Martinho, A., Antunes, O., Silva, E., Ambrósio, A. P., Geraldes, M. C., Nascimento, R., Silva, C., Pereira, J. M., Júnior, E. C. & Jordan, P., 1 Jun 2008, In : Diagnostic Molecular Pathology. 17, 2, p. 73-81 9 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Follicular Lymphoma
Immunoglobulin Heavy Chains
Lymphoma
Polymerase Chain Reaction
36 Citations (Scopus)

Comparative analysis of the mutagenic activity of oxaliplatin and cisplatin in the Hprt gene of CHO cells

Silva, M. J., Costa, P., Dias, A., Valente, M., Louro, H. & Boavida, M. G., 1 Aug 2005, In : Environmental And Molecular Mutagenesis. 46, 2, p. 104-115 12 p.

Research output: Contribution to journalArticle

oxaliplatin
CHO Cells
Cisplatin
mutation
Genes
16 Citations (Scopus)
Acrylamide
Chromosome Aberrations
Glutathione
Buthionine Sulfoximine
Esters
17 Citations (Scopus)

Detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma

Neves, A. M., Thompson, G., Carvalheira, J., Trindade, J. C., Rueff, J., Caetano, J. M., Casey, J. W. & Hermouet, S., 24 Jul 2008, In : Brain Research. 1221, p. 108-114 7 p.

Research output: Contribution to journalArticle

Herpesviridae
Astrocytoma
DNA-Directed DNA Polymerase
Human Herpesvirus 8
Human Herpesvirus 4
15 Citations (Scopus)

Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation

Larguinho, M., Santos, H. M., Doria, G., Scholz, H., Baptista, P. V. & Capelo, J. L., 15 May 2010, In : Talanta. 81, 3, p. 881-886 6 p.

Research output: Contribution to journalArticle

Ultrasonics
DNA
DNA Probes
Plasmids
Contamination
42 Citations (Scopus)
5 Citations (Scopus)

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells.

Dinis, J., Silva, V., Gromicho, M., Martins, C., Laires, A., Tavares, P., Rendeiro, P., Torres, F., Rueff, J. & Rodrigues, AS., 2012, In : Leukemia & Lymphoma. 53, 10, p. 2004-14 11 p.

Research output: Contribution to journalArticle

K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Damage
DNA Repair
Protein-Tyrosine Kinases
27 Citations (Scopus)
Open Access
18 Citations (Scopus)
Open Access
15 Citations (Scopus)

Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen

Martins, C., Cação, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J. & Rodrigues, A. S., 2012, In : Mutation Research-Genetic Toxicology And Environmental Mutagenesis. 747, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Mutagens
Carcinogens
Comet Assay
Food
DNA Adducts
22 Citations (Scopus)

Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels

Larguinho, M., Correia, D., Diniz, M. & Baptista, P., 15 Jul 2014, In : Journal Of Nanoparticle Research. 16, 8, 11 p., 2549.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
16 Citations (Scopus)

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Oxidoreductases
NADPH-Ferrihemoprotein Reductase
1 Citation (Scopus)

Genetic Basis of Nonsyndromic Sensorineural Hearing Loss in the Sub-Saharan African Island Population of São Tomé and Príncipe: The Role of the DFNB1 Locus?

Caroça, C., De Matos, T. M., Ribeiro, D., Lourenço, V., Martins, T., Campelo, P., Fialho, G., Nunes Silva, S., Paço, J. & Caria, H., Aug 2016, In : Omics-A Journal Of Integrative Biology. 20, 8, p. 449-455 7 p.

Research output: Contribution to journalArticle

Audition
Islands
Population
Hearing Loss
Mutation
31 Citations (Scopus)

Genomics and Cancer Drug Resistance

Rodrigues, A. S., Dinis, J., Gromicho, M., Martins, C., Laires, A. & Rueff, J., 1 Jan 2012, In : Current Pharmaceutical Biotechnology. 13, 5, p. 651-673

Research output: Contribution to journalArticle

23 Citations (Scopus)
Glutathione Transferase
Doxorubicin
Genotype
Lymphocytes
Micronucleus Tests
5 Citations (Scopus)
114 Citations (Scopus)

Gold and silver nanoparticles for clinical diagnostics - From genomics to proteomics.

Baptista, P. M. R. V., 1 Jan 2011, In : Journal of Proteomics. 75, NA, p. 2811-23

Research output: Contribution to journalArticle

Open Access
Nanotechnology
Genomics
Silver
Gold
Proteomics
56 Citations (Scopus)
Open Access
69 Citations (Scopus)
Open Access
42 Citations (Scopus)
Open Access
Immunoassay
Gold
Nanoparticles
Malaria
Fluorescence
338 Citations (Scopus)

Gold nanoparticles for the development of clinical diagnosis methods

Baptista, P. M. R. V. & Franco, R., 1 Jan 2008, In : Analytical and Bioanalytical Chemistry. 391, 3, p. 943-950

Research output: Contribution to journalArticle

Open Access
338 Citations (Scopus)

Gold nanoparticles for the development of clinical diagnosis methods

Baptista, P. M. R. V. & Franco, R., 1 Jan 2008, In : Analytical and Bioanalytical Chemistry. 391, 3, p. 943-950

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Gold nanoparticle-siRNA mediated oncogene knockdown at RNA and protein level, with associated gene effects

Child, H. W., Hernandez, Y., Conde, J., Mullin, M., Baptista, P., Maria de la Fuente, J. & Berry, C. C., 2015, In : Nanomedicine. 10, 16, p. 2513-2525 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis

Pedrosa, P., Veigas, B., Machado, D., Couto, I., Viveiros, M. & Baptista, P., May 2014, In : Tuberculosis. 94, 3, p. 332-337 6 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Gold
Rifampin
Mycobacterium tuberculosis
Genes
39 Citations (Scopus)
9 Downloads (Pure)

Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

Marohnic, C. C., Panda, S. P., McCammon, K. M., Rueff, J., Masters, B. S. S. & Kranendonk, M., 1 Jan 2010, In : Drug Metabolism And Disposition. 38, 2, p. 332-340

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)

Human exposure to indoor radon: a survey in the region of Guarda, Portugal

Louro, A., Peralta, L., Soares, S., Pereira, A., Cunha, G., Belchior, A., Ferreira, L., Gil, OM., Louro, H., Pinto, P., Rodrigues, A. S., Silva, MJ. & Teles, P., 2013, In : Radiation Protection Dosimetry. 154, 2, p. 237-244

Research output: Contribution to journalArticle

Portugal
Radon
radon
Gases
tobacco
4 Citations (Scopus)
Nevirapine
Metabolites
Liver
Skin
Mutagenicity Tests
24 Citations (Scopus)

Increased levels of sister chromatid exchanges in military aircraft pilots

Silva, M. J., Carothers, A., Castelo Branco, N., Dias, A. & Boavida, M. G., 26 Apr 1999, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 441, 1, p. 129-134 6 p.

Research output: Contribution to journalArticle

Sister Chromatid Exchange
Aircraft
Vibration
Noise
Cell Count
10 Citations (Scopus)
Sister Chromatid Exchange
Acrylamide
DNA Repair
Lymphocytes
Genes
20 Citations (Scopus)

Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies

Luis, DV., Silva, J., Tomaz, AI., de Almeida, RFM., Larguinho, M., Baptista, P. V., Martins, LMDRS., Silva, TFS., Borralho, PM., Rodrigues, CMP., Rodrigues, A. S., Pombeiro, AJL. & Fernandes, A. R., 1 Jan 2014, In : Journal Of Biological Inorganic Chemistry. 19, 6, p. 787-803

Research output: Contribution to journalArticle

24 Citations (Scopus)
RNA Stability
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Genes
Therapeutics
12 Citations (Scopus)

Instability of the human cytochrome P450 reductase A287P variant is the major contributor to its Antley-Bixler syndrome-like phenotype

McCammon, K. M., Panda, S. P., Xia, C., Kim, J. J. P., Moutinho, D., Kranendonk, M., Auchus, R. J., Lafer, E. M., Ghosh, D., Martasek, P., Kar, R., Masters, B. S. & Roman, L. J., 23 Sep 2016, In : Journal of Biological Chemistry. 291, 39, p. 20487-20502 16 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
NADPH-Ferrihemoprotein Reductase
Oxidoreductases
Differential Scanning Calorimetry
Proteins