Centro de Investigação em Genética Molecular Humana (CIGMH)

  • Portugal

Research Output 1994 2017

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Article
1994
5 Citations (Scopus)
1996
6 Citations (Scopus)
Nitrosation
Gastric Juice
Glycine
Chlorides
Stomach
1998
13 Citations (Scopus)

Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer

Cristóvão, L., Lechner, M. C., Fidalgo, P., Leitão, C. N., Mira, F. C. & Rueff, J., 1 Jan 1998, In : British Journal of Cancer. 77, 10, p. 1628-1632 5 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Colonic Neoplasms
Adenomatous Polyposis Coli
NAD
Radiation
1999
24 Citations (Scopus)

Increased levels of sister chromatid exchanges in military aircraft pilots

Silva, M. J., Carothers, A., Castelo Branco, N., Dias, A. & Boavida, M. G., 26 Apr 1999, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 441, 1, p. 129-134 6 p.

Research output: Contribution to journalArticle

Sister Chromatid Exchange
Aircraft
Vibration
Noise
Cell Count
2002
19 Citations (Scopus)

Mutagenic activity of cisplatin in the lacZ plasmid-based transgenic mouse model

Louro, H., Silva, M. J. & Boavida, M. G., 1 Dec 2002, In : Environmental And Molecular Mutagenesis. 40, 4, p. 283-291 9 p.

Research output: Contribution to journalArticle

plasmid
Cisplatin
Transgenic Mice
mutation
Plasmids
2005
86 Citations (Scopus)

Colorimetric detection of eukaryotic gene expression with DNA-derivatized gold nanoparticles

Baptista, P. M. R. V., Dória, G., Henriques, D., Pereira, E. & Franco, R., 1 Jan 2005, In : Journal of Biotechnology. 119, 2, p. 111-7 7 p.

Research output: Contribution to journalArticle

Open Access
RNA
Gene expression
Gold
Nanoparticles
DNA
36 Citations (Scopus)

Comparative analysis of the mutagenic activity of oxaliplatin and cisplatin in the Hprt gene of CHO cells

Silva, M. J., Costa, P., Dias, A., Valente, M., Louro, H. & Boavida, M. G., 1 Aug 2005, In : Environmental And Molecular Mutagenesis. 46, 2, p. 104-115 12 p.

Research output: Contribution to journalArticle

oxaliplatin
CHO Cells
Cisplatin
mutation
Genes
2007
39 Citations (Scopus)
Open Access
Nucleic acid sequences
Nanocrystalline silicon
Amorphous silicon
Biosensors
Gold
57 Citations (Scopus)

Macrocyclic copper(II) complexes: Superoxide scavenging activity, structural studies and cytotoxicity evaluation

Fernandes, A. S., Gaspar, J., Cabral, M. F., Caneiras, C., Guedes, R., Rueff, J., Castro, M., Costa, J. & Oliveira, N. G., 1 May 2007, In : Journal of Inorganic Biochemistry. 101, 5, p. 849-858 10 p.

Research output: Contribution to journalArticle

Scavenging
Cytotoxicity
Superoxides
Copper
Assays
3 Citations (Scopus)

Combined molecular diagnosis of b-cell lymphomas with t(11;14)(q13;q32) or t(14;18)(q32;q21) using multiplex- and long distance inverse-polymerase chain reaction

Vieira, L., Martinho, A., Antunes, O., Silva, E., Ambrósio, A. P., Geraldes, M. C., Nascimento, R., Silva, C., Pereira, J. M., Júnior, E. C. & Jordan, P., 1 Jun 2008, In : Diagnostic Molecular Pathology. 17, 2, p. 73-81 9 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Follicular Lymphoma
Immunoglobulin Heavy Chains
Lymphoma
Polymerase Chain Reaction
17 Citations (Scopus)

Detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma

Neves, A. M., Thompson, G., Carvalheira, J., Trindade, J. C., Rueff, J., Caetano, J. M., Casey, J. W. & Hermouet, S., 24 Jul 2008, In : Brain Research. 1221, p. 108-114 7 p.

Research output: Contribution to journalArticle

Herpesviridae
Astrocytoma
DNA-Directed DNA Polymerase
Human Herpesvirus 8
Human Herpesvirus 4
338 Citations (Scopus)

Gold nanoparticles for the development of clinical diagnosis methods

Baptista, P. M. R. V. & Franco, R., 1 Jan 2008, In : Analytical and Bioanalytical Chemistry. 391, 3, p. 943-950

Research output: Contribution to journalArticle

Open Access
338 Citations (Scopus)

Gold nanoparticles for the development of clinical diagnosis methods

Baptista, P. M. R. V. & Franco, R., 1 Jan 2008, In : Analytical and Bioanalytical Chemistry. 391, 3, p. 943-950

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice

Louro, H., Pinheiro, I., Costa, P., Sousa, C., Dias, A., Boavida, M. G. & Silva, M. J., 2 Apr 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 640, 1-2, p. 82-88 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Testis
Point Mutation
Lac Operon
Sequence Deletion
2009
16 Citations (Scopus)
Acrylamide
Chromosome Aberrations
Glutathione
Buthionine Sulfoximine
Esters
18 Citations (Scopus)

Tc-99m-Tricarbonyl Complexes Functionalized with Anthracenyl Fragments: Synthesis, Characterization, and Evaluation of Their Radiotoxic Effects in Murine Melanoma Cells

Vitor, RF., Esteves, T., Marques, F., Raposinho, P., Paulo, A., Rodrigues, A. S., Rueff, J., Casimiro, S., Costa, L. & Santos, I., 1 Oct 2009, In : Cancer biotherapy & radiopharmaceuticals. 24, 5, p. 551-563 13 p.

Research output: Contribution to journalArticle

Melanoma
Diamines
DNA
Electrons
Ligands
2010
15 Citations (Scopus)

Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation

Larguinho, M., Santos, H. M., Doria, G., Scholz, H., Baptista, P. V. & Capelo, J. L., 15 May 2010, In : Talanta. 81, 3, p. 881-886 6 p.

Research output: Contribution to journalArticle

Ultrasonics
DNA
DNA Probes
Plasmids
Contamination
39 Citations (Scopus)
9 Downloads (Pure)

Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

Marohnic, C. C., Panda, S. P., McCammon, K. M., Rueff, J., Masters, B. S. S. & Kranendonk, M., 1 Jan 2010, In : Drug Metabolism And Disposition. 38, 2, p. 332-340

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
14 Citations (Scopus)
Photochemical reactions
Quantum yield
photochemical reactions
esters
phosphates
20 Citations (Scopus)

Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide

Fernandes, A. S., Gaspar, J., Cabral, M. F., Rueff, J., Castro, M., Batinic-Haberle, I., Costa, J. & Oliveira, N. G., 19 Mar 2010, In : Free Radical Research. 44, 4, p. 430-440 11 p.

Research output: Contribution to journalArticle

tert-Butylhydroperoxide
Cells
Wounds and Injuries
Glutathione
Assays
22 Citations (Scopus)

Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands

Silva, F., Marques, F., Santos, I. C., Paulo, A., Rodrigues, A. S., Rueff, J. & Santos, I., 1 Jan 2010, In : Journal of Inorganic Biochemistry. 104, 5, p. 523-532

Research output: Contribution to journalArticle

2011
13 Citations (Scopus)

ACMA (9-amino-6-chloro-2-methoxy acridine) forms three complexes in the presence of DNA

Busto, N., García, B., Leal, J. M., Gaspar, J. F., Martins, C., Boggioni, A. & Secco, F., 21 Nov 2011, In : Physical Chemistry Chemical Physics. 13, 43, p. 19534-19545 12 p.

Research output: Contribution to journalArticle

Acridines
deoxyribonucleic acid
DNA
kinetics
dyes
42 Citations (Scopus)
23 Citations (Scopus)
Glutathione Transferase
Doxorubicin
Genotype
Lymphocytes
Micronucleus Tests
114 Citations (Scopus)

Gold and silver nanoparticles for clinical diagnostics - From genomics to proteomics.

Baptista, P. M. R. V., 1 Jan 2011, In : Journal of Proteomics. 75, NA, p. 2811-23

Research output: Contribution to journalArticle

Open Access
Nanotechnology
Genomics
Silver
Gold
Proteomics
11 Citations (Scopus)
Oxyquinoline
Chromophores
chromophores
Metal ions
metal ions
2012
19 Citations (Scopus)

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Human Activities
Cytochrome P-450 Enzyme System
5 Citations (Scopus)

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells.

Dinis, J., Silva, V., Gromicho, M., Martins, C., Laires, A., Tavares, P., Rendeiro, P., Torres, F., Rueff, J. & Rodrigues, AS., 2012, In : Leukemia & Lymphoma. 53, 10, p. 2004-14 11 p.

Research output: Contribution to journalArticle

K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Damage
DNA Repair
Protein-Tyrosine Kinases
27 Citations (Scopus)
Open Access
18 Citations (Scopus)
Open Access
15 Citations (Scopus)

Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen

Martins, C., Cação, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J. & Rodrigues, A. S., 2012, In : Mutation Research-Genetic Toxicology And Environmental Mutagenesis. 747, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Mutagens
Carcinogens
Comet Assay
Food
DNA Adducts
31 Citations (Scopus)

Genomics and Cancer Drug Resistance

Rodrigues, A. S., Dinis, J., Gromicho, M., Martins, C., Laires, A. & Rueff, J., 1 Jan 2012, In : Current Pharmaceutical Biotechnology. 13, 5, p. 651-673

Research output: Contribution to journalArticle

42 Citations (Scopus)
Open Access
Immunoassay
Gold
Nanoparticles
Malaria
Fluorescence

Multifunctional gold nanoparticles for gene silencing

Baptista, P. M. R. V., 1 Jan 2012, In : Abstracts Of Papers Of The American Chemical Society. 243, NA, p. -

Research output: Contribution to journalArticle

3 Citations (Scopus)

Unspliced Precursors of NMD-Sensitive β-Globin Transcripts Exhibit Decreased Steady-State Levels in Erythroid Cells.

Morgado, A., Almeida, F., Teixeira, A., Silva, A. L. & Romão, L., 1 Jan 2012, In : PLoS ONE. 7, 6, p. Online

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Erythroid Cells
Globins
Nonsense Codon
stop codon
2013
16 Citations (Scopus)
Open Access
4 Citations (Scopus)
Open Access
16 Citations (Scopus)

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Oxidoreductases
NADPH-Ferrihemoprotein Reductase
69 Citations (Scopus)
Open Access
4 Citations (Scopus)

Human exposure to indoor radon: a survey in the region of Guarda, Portugal

Louro, A., Peralta, L., Soares, S., Pereira, A., Cunha, G., Belchior, A., Ferreira, L., Gil, OM., Louro, H., Pinto, P., Rodrigues, A. S., Silva, MJ. & Teles, P., 2013, In : Radiation Protection Dosimetry. 154, 2, p. 237-244

Research output: Contribution to journalArticle

Portugal
Radon
radon
Gases
tobacco
10 Citations (Scopus)
Sister Chromatid Exchange
Acrylamide
DNA Repair
Lymphocytes
Genes
24 Citations (Scopus)
RNA Stability
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Genes
Therapeutics
89 Citations (Scopus)
Open Access