Centro de Investigação em Genética Molecular Humana (CIGMH)

  • Portugal

Research Output 1994 2017

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Article
2017
6 Citations (Scopus)

Analysis of Pelagia noctiluca proteome Reveals a Red Fluorescent Protein, a Zinc Metalloproteinase and a Peroxiredoxin

Frazao, B., Campos, A., Osorio, H., Thomas, B., Leandro, S., Teixeira, A., Vasconcelos, V. & Antunes, A., Apr 2017, In : Protein Journal. 36, 2, p. 77-97 11 p.

Research output: Contribution to journalArticle

2016
1 Citation (Scopus)

Genetic Basis of Nonsyndromic Sensorineural Hearing Loss in the Sub-Saharan African Island Population of São Tomé and Príncipe: The Role of the DFNB1 Locus?

Caroça, C., De Matos, T. M., Ribeiro, D., Lourenço, V., Martins, T., Campelo, P., Fialho, G., Nunes Silva, S., Paço, J. & Caria, H., Aug 2016, In : Omics-A Journal Of Integrative Biology. 20, 8, p. 449-455 7 p.

Research output: Contribution to journalArticle

Audition
Islands
Population
Hearing Loss
Mutation
12 Citations (Scopus)

Instability of the human cytochrome P450 reductase A287P variant is the major contributor to its Antley-Bixler syndrome-like phenotype

McCammon, K. M., Panda, S. P., Xia, C., Kim, J. J. P., Moutinho, D., Kranendonk, M., Auchus, R. J., Lafer, E. M., Ghosh, D., Martasek, P., Kar, R., Masters, B. S. & Roman, L. J., 23 Sep 2016, In : Journal of Biological Chemistry. 291, 39, p. 20487-20502 16 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
NADPH-Ferrihemoprotein Reductase
Oxidoreductases
Differential Scanning Calorimetry
Proteins
1 Citation (Scopus)
Human Genome
Viruses
Genes
HIV
Virus Integration
14 Citations (Scopus)

MicroRNAs and Cancer Drug Resistance

Gomes, B. C., Rueff, J. & Rodrigues, A. S., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. 137-62 26 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Small Untranslated RNA
Neoplasms
Epithelial-Mesenchymal Transition

Preface

Rueff, J. & Rodrigues, AS., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. v-vii

Research output: Contribution to journalArticle

9 Citations (Scopus)

Prognostic value of microRNA-203a expression in breast cancer

Gomes, B. C., Martins, M., Lopes, P., Morujão, I., Oliveira, M., Araújo, A., Rueff, J. & Rodrigues, AS., 1 Sep 2016, In : Oncology Reports. 36, 3, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Breast Neoplasms
Neoplasms
Lobular Carcinoma
Carcinoma, Intraductal, Noninfiltrating
2015
9 Citations (Scopus)

Gold nanoparticle-siRNA mediated oncogene knockdown at RNA and protein level, with associated gene effects

Child, H. W., Hernandez, Y., Conde, J., Mullin, M., Baptista, P., Maria de la Fuente, J. & Berry, C. C., 2015, In : Nanomedicine. 10, 16, p. 2513-2525 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity

Pereira, F. J. C., Teixeira, A. R. S., Kong, J., Barbosa, C., Silva, A. L., Marques-Ramos, A., Liebhaber, S. A. & Romão, L., 23 May 2015, In : Nucleic Acids Research. 43, 13, p. 6528-6544 17 p.

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Nonsense Codon
Messenger RNA
Globins
Open Reading Frames
5 Citations (Scopus)

Single Nucleotide Polymorphism Detection Using Gold Nanoprobes and Bio-Microfluidic Platform With Embedded Microlenses

Bernacka-Wojcik, I., Aguas, H., Carlos, F. F., Lopes, P., Wojcik, P. J., Costa, M. N., Veigas, B., Igreja, R., Fortunato, E., Baptista, P. & Martins, R., 10 Mar 2015, In : Biotechnology and Bioengineering. 112, 6, p. 1210-1219 10 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
Open Access
66 Citations (Scopus)

Antibody-drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics

Conde, J., Bao, C., Cui, D., Baptista, P. & Tian, F., 10 Jun 2014, In : Journal Of Controlled Release. 183, p. 87-93 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

A promising road with challenges: where are gold nanoparticles in translational research?

Bao, C., Conde, J., Polo, E., del Pino, P., Moros, M., Baptista, P., Grazu, V., Cui, D. & de la Fuente, J. M., 2014, In : Nanomedicine. 9, 15, p. 2353-2370 18 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Characterization of genomic single nucleotide polymorphism via colorimetric detection using a single gold nanoprobe

Carlos, F. F., Flores, O., Doria, G. & Baptista, P., 15 Nov 2014, In : Analytical Biochemistry. 465, p. 1-5 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Chitosan mouthwash: Toxicity and in vivo validation

Costa, E. M., Silva, S., Costa, M. R., Pereira, M., Campos, D. A., Odila, J., Madureira, A. R., Cardelle-Cobas, A., Tavaria, F. K., Rodrigues, A. S. & Pintado, M. M., 2014, In : Carbohydrate Polymers. 111, NA, p. 385-392 8 p.

Research output: Contribution to journalArticle

Mouthwashes
Chitosan
Toxicity
Assays
Cytotoxicity
1 Citation (Scopus)

Dual-color control of nucleotide polymerization sensed by a fluorescence actuator

Reimao-Pinto, M. M., Cordeiro, A., Almeida, C., Pinheiro, A. V., Moro, A., Lima, J. C. & Baptista, P., 2014, In : Photochemical and Photobiological Sciences. 13, 5, p. 751-756 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels

Larguinho, M., Correia, D., Diniz, M. & Baptista, P., 15 Jul 2014, In : Journal Of Nanoparticle Research. 16, 8, 11 p., 2549.

Research output: Contribution to journalArticle

56 Citations (Scopus)
Open Access
13 Citations (Scopus)

Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis

Pedrosa, P., Veigas, B., Machado, D., Couto, I., Viveiros, M. & Baptista, P., May 2014, In : Tuberculosis. 94, 3, p. 332-337 6 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Gold
Rifampin
Mycobacterium tuberculosis
Genes
4 Citations (Scopus)
Nevirapine
Metabolites
Liver
Skin
Mutagenicity Tests
20 Citations (Scopus)

Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies

Luis, DV., Silva, J., Tomaz, AI., de Almeida, RFM., Larguinho, M., Baptista, P. V., Martins, LMDRS., Silva, TFS., Borralho, PM., Rodrigues, CMP., Rodrigues, A. S., Pombeiro, AJL. & Fernandes, A. R., 1 Jan 2014, In : Journal Of Biological Inorganic Chemistry. 19, 6, p. 787-803

Research output: Contribution to journalArticle

25 Citations (Scopus)
Open Access
Ions
DNA
Point-of-Care Systems
Equipment and Supplies
Proto-Oncogenes
15 Citations (Scopus)
13 Citations (Scopus)
Myristica fragrans
K562 Cells
DNA Damage
Leukemia
Down-Regulation
23 Citations (Scopus)
Open Access
12 Citations (Scopus)

Polyurea dendrimer for efficient cytosolic siRNA delivery

Cidade, M. T. V. & Baptista, P., 1 Jan 2014, In : RSC ADVANCES. 4, 97, p. 54872-54878

Research output: Contribution to journalArticle

Open Access
56 Citations (Scopus)

Star-shaped magnetite@gold nanoparticles for protein magnetic separation and SERS detection

Quaresma, P., Osório, I., Dória, G., Carvalho, P. A., Pereira, A., Langer, J., Araújo, J. P., Pastoriza-Santos, I., Liz-Marzán, L. M., Franco, R., Baptista, P. & Pereira, E., 2014, In : RCS Advances. 4, 8, p. 3659-3667 9 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Magnetic separation
Magnetite
Gold
Stars
2013
16 Citations (Scopus)
Open Access
4 Citations (Scopus)
Open Access
16 Citations (Scopus)

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Oxidoreductases
NADPH-Ferrihemoprotein Reductase
69 Citations (Scopus)
Open Access
4 Citations (Scopus)

Human exposure to indoor radon: a survey in the region of Guarda, Portugal

Louro, A., Peralta, L., Soares, S., Pereira, A., Cunha, G., Belchior, A., Ferreira, L., Gil, OM., Louro, H., Pinto, P., Rodrigues, A. S., Silva, MJ. & Teles, P., 2013, In : Radiation Protection Dosimetry. 154, 2, p. 237-244

Research output: Contribution to journalArticle

Portugal
Radon
radon
Gases
tobacco
10 Citations (Scopus)
Sister Chromatid Exchange
Acrylamide
DNA Repair
Lymphocytes
Genes
24 Citations (Scopus)
RNA Stability
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Genes
Therapeutics
89 Citations (Scopus)
Open Access
Open Access

Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

Martins, P., Rosa, D., Fernandes, A. R. & Baptista, P., Jan 2013, In : Recent Patents on Nanomedicine. 3, 2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Nanomedicine
Medical nanotechnology
Patents
Drug Delivery Systems
Drug delivery

Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites

Sequeira, I. J. D. S., Mexia, J. T. P. N., Santiago, J., Mamede, R., Silva, E., Santos, J., Faria, D., Rueff, J. & Brás, A., 1 Jan 2013, In : Open Journal of Genetics. 3, NA, p. 8-13

Research output: Contribution to journalArticle

Open Access
File

The chemistry and biology of gold nanoparticle-mediated photothermal therapy: promises and challenges

Baptista, P. M. R. V., 1 Jan 2013, In : Nano LIFE. 03, 03, p. nr. 1330001

Research output: Contribution to journalArticle

Open Access
2012
19 Citations (Scopus)

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Human Activities
Cytochrome P-450 Enzyme System
5 Citations (Scopus)

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells.

Dinis, J., Silva, V., Gromicho, M., Martins, C., Laires, A., Tavares, P., Rendeiro, P., Torres, F., Rueff, J. & Rodrigues, AS., 2012, In : Leukemia & Lymphoma. 53, 10, p. 2004-14 11 p.

Research output: Contribution to journalArticle

K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Damage
DNA Repair
Protein-Tyrosine Kinases
27 Citations (Scopus)
Open Access
18 Citations (Scopus)
Open Access
15 Citations (Scopus)

Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen

Martins, C., Cação, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J. & Rodrigues, A. S., 2012, In : Mutation Research-Genetic Toxicology And Environmental Mutagenesis. 747, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Mutagens
Carcinogens
Comet Assay
Food
DNA Adducts