Centro de Estudos de Doenças Crónicas (CEDOC)

Research output

Research output per year 2004 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 1510 Article
• 492 Meeting Abstract
• 210 Review article
• 64 Letter
• 259 More
  • 57 Chapter
  • 55 Editorial
  • 43 Comment/debate
  • 36 Other contribution
  • 15 Conference contribution
  • 12 Regional/Other National Application
  • 5 Book
  • 5 Abstract
  • 5 Poster
  • 5 Short survey
  • 4 Book/Film/Article review
  • 3 Paper
  • 3 International PCT application
  • 2 Other
  • 2 Conference article
  • 1 Commissioned report
  • 1 Scholarly edition
  • 1 Literature review
  • 1 National Final Application
  • 1 Doctoral Thesis
  • 1 Master's Thesis
  • 1 Working paper

Research output per year

Research output per year

Search results

• 2021

  Rho-kinase as a therapeutic target for nonalcoholic fatty liver diseases

  Sousa-Lima, I., Kim, H. J., Jones, J. & Kim, Y. B., Sept 2021, In: Diabetes and Metabolism Journal. 45, 5, p. 655-674 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • rho-Associated Kinases 100%
  • Non-alcoholic Fatty Liver Disease 86%
  • Liver Diseases 68%
  • Fatty Liver 43%
  • Lipogenesis 33%
  5 Citations (Scopus)

  46 Downloads (Pure)

• Rice Compounds with Impact on Diabetes Control

  Pereira, C., Lourenço, V. M., Menezes, R. & Brites, C., Sept 2021, In: Foods. 10, 9, p. 1-18 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Oryza 100%
  • diabetes 89%
  • agricultural product 89%
  • chronic illness 83%
  • rice 55%
  74 Downloads (Pure)

• RISCOP–Cognitive profile in a Portuguese cohort of radiological isolated syndrome patients: A case-control study

  Carvalho, V., Soares, C., Gomes, I., Carvalho, A., Serrazina, F., Rodrigues, S. G., Pinheiro, J., Marques, I. B., Correia, F., Correia, A. S., de Sá, J., Sousa, L., Vale, J., Sá, M. J., Sousa, C. & Ferreira, J., May 2021, In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 50, 102832.

  Research output: Contribution to journal › Article › peer-review

  • Case-Control Studies 100%
  • Cognitive Dysfunction 30%
  • Fatigue 20%
  • 4-amino-4'-hydroxylaminodiphenylsulfone 18%
  • Memory and Learning Tests 17%

• Safety of vaccination against SARS-CoV-2 in people with rheumatic and musculoskeletal diseases: results from the EULAR Coronavirus Vaccine (COVAX) physician-reported registry

  Machado, P. M., Lawson-Tovey, S., Strangfeld, A., Mateus, E. F., Hyrich, K. L., Gossec, L., Carmona, L., Rodrigues, A., Raffeiner, B., Duarte, C., Hachulla, E., Veillard, E., Strakova, E., Burmester, G. R., Yardımcı, G. K., Gomez-Puerta, J. A., Zepa, J., Kearsley-Fleet, L., Trefond, L., Cunha, M., & 11 othersMosca, M., Cornalba, M., Soubrier, M., Roux, N., Brocq, O., Durez, P., Conway, R., Goulenok, T., Bijlsma, J. W., McInnes, I. B. & Mariette, X., 2021, (E-pub ahead of print) In: Annals of the rheumatic diseases. 81, 5, p. 695-709 15 p., 221490.

  Research output: Contribution to journal › Article › peer-review

  • Musculoskeletal 100%
  • SARS Virus 91%
  • Musculoskeletal Diseases 83%
  • Coronavirus 77%
  • Rheumatic Diseases 66%
  89 Citations (Scopus)

• SARS-coV-2 infection in asthma/ recurrent wheezing - the reality of a pediatric hospital during 2020

  Goncalves, T., Lobato, M., Pita, J. S., Romeira, A. M., Brito, M. J., Matos, V. & Pinto, P. L., Nov 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, p. 196-197

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Screening for diabetic retinopathy using an automated diagnostic system based on deep learning: Diagnostic accuracy assessment

  Rêgo, S., Dutra Medeiros, M., Soares, F. & Monteiro-Soares, M., 1 Jul 2021, In: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 244, 3, p. 250-257

  Research output: Contribution to journal › Article › peer-review

  • Deep Learning 100%
  • Diabetic Retinopathy 76%
  • Computer Neural Networks 54%
  • Confidence Intervals 43%
  • Ophthalmologists 23%
  12 Citations (Scopus)

• Secondary Trigeminal Neuralgia: Do Not Forget the Pontine Ischemic Infarction

  Cabral, G., Lorga, T., Caetano, A., Baptista, T. & Baptista, M. V., 1 Aug 2021, In: European Neurology. 84, 5, p. 391-392 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Citations (Scopus)

• Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination

  Gonçalves, J., Juliano, A. M., Charepe, N., Alenquer, M., Athayde, D., Ferreira, F., Archer, M., Amorim, M. J., Serrano, F. & Soares, H., 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100468.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Secretory Immunoglobulin A 89%
  • Neutralization 68%
  • Protective 56%
  • Vaccination 54%
  20 Citations (Scopus)

  11 Downloads (Pure)

• Sensorineural Hearing Loss and Systemic Autoimmune Disease: The Experience of a Systemic Immune-Mediated Diseases Unit

  Ribeiro, R., Serodio, J. F., Amaral, M. C., Duarte, J. A., Durao, C., Mendes, N. & Alves, J. D., 24 Mar 2021

  Research output: Other contribution › peer-review

• Serum levels of placental growth factor reflect the severity of retinopathy of prematurity

  Almeida, A., Bitoque, D. B., Martins, C., Coelho, C., Borrego, L. M. & Silva, G. A., Oct 2021, In: Acta Paediatrica. p. 2778-2779

  Research output: Contribution to journal › Article › peer-review

  • Retinopathy of Prematurity 100%
  • Retina 69%
  • Intercellular Signaling Peptides and Proteins 64%
  • Retinal Vessels 46%
  • Angiogenesis Inducing Agents 44%
  1 Citation (Scopus)

• Serum markers of B cell activation in pregnant women with atopic asthma

  Martins, C., Lima, J., Cambridge, G., Ângelo-Dias, M., Leandro, M. & Borrego, L. M., 7 Mar 2021, In: American journal of reproductive immunology (New York, N.Y. : 1989). e13414.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pregnant Women 100%
  • Asthma 96%
  • B-Lymphocytes 95%
  • Biomarkers 80%
  • Hypersensitivity 37%
  1 Citation (Scopus)

  2 Downloads (Pure)

• Sesquiterpene lactones: Promising natural compounds to fight inflammation

  Matos, M. S., Anastácio, J. D. & Dos Santos, C. N., Jul 2021, In: Pharmaceutics. 13, 7, 991.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Sesquiterpenes 100%
  • Sesquiterpene Lactone 97%
  • Lactones 94%
  • Antiinflammatory 70%
  • Occurrence in Nature 60%
  30 Citations (Scopus)

• Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases: Lipid profiling of chronic diseases

  Matthiesen, R., Lauber, C., Sampaio, J. L., Domingues, N., Alves, L., Gerl, M. J., Almeida, M. S., Rodrigues, G., Araújo Gonçalves, P., Ferreira, J., Borbinha, C., Pedro Marto, J., Neves, M., Batista, F., Viana-Baptista, M., Alves, J., Simons, K., Vaz, W. L. C. & Vieira, O. V., Aug 2021, In: EBioMedicine. 70, 103504.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Firearms 100%
  • Lipidomics 99%
  • Mass Spectrometry 79%
  • Chronic Disease 65%
  • Lipid 60%
  7 Citations (Scopus)

  7 Downloads (Pure)

• Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

  Alenquer, M., Ferreira, F., Lousa, D., Valério, M., Medina-Lopes, M., Bergman, M. L., Gonçalves, J., Demengeot, J., Leite, R. B., Lilue, J., Ning, Z., Penha-Gonçalves, C., Soares, H., Soares, C. M. & Amorim, M. J., Aug 2021, In: PLoS Pathogens. 17, 8, e1009772.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • neutralizing antibodies 78%
  • Neutralizing Antibodies 67%
  • mutation 46%
  • Mutation 37%
  46 Citations (Scopus)

• Síndrome da panqueca e hipersensibilidade a aines: A propósito de um caso clínico

  Translated title of the contribution: Pancake syndrome and hypersensitivity to nsaids: A case reportLobato, M. D. C. B., Palhinha, A., Romeira, A. M. & Pinto, P. L., 2021, In: Revista Portuguesa de Imunoalergologia. 29, 3, p. 215-218 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flour 100%
  • Triticum 91%
  • Hypersensitivity 61%
  • Anaphylaxis 61%
  • Mites 47%
  9 Downloads (Pure)

• Sleep, stress, burnout, and depressive symptoms among healthcare workers from COVID-19 services: findings from a cross-sectional study on psychosocial risks

  Gouveia, P. A., Moura, P., Lopes, D., Henriques, A. R. & Matos Pires, A., Dec 2021, In: European Neuropsychopharmacology. 53, p. S523-S523

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Small molecule fisetin modulates alpha-Synuclein aggregation

  Rosado-Ramos, R., Godinho-Pereira, J., Marques, D., Figueira, I., Outeiro, T. F., Menezes, R. & Dos Santos, C. N., 1 Jun 2021, In: Molecules. 26, 11, 3353.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • fisetin 100%
  • Parkinson disease 97%
  • Fisetin 96%
  • Synucleins 74%
  • alpha-Synuclein 73%
  9 Citations (Scopus)

  16 Downloads (Pure)

• Soluble CD40 ligand expression in stable atherosclerosis: A systematic review and meta-analysis

  Pereira-da-Silva, T., Ferreira, V., Castelo, A., Caldeira, D., Napoleão, P., Pinheiro, T., Ferreira, R. C. & Carmo, M. M., Feb 2021, In: Atherosclerosis. 319, p. 86-100 15 p.

  Research output: Contribution to journal › Article › peer-review

  • CD40 Ligand 100%
  • Atherosclerosis 65%
  • Meta-Analysis 60%
  • Systematic Reviews 59%
  • Library Science 11%
  4 Citations (Scopus)

• Staff SARS-CoV-2 Seroprevalence and Mental Health as Key Factors in University Response to COVID-19 Pandemic

  Lopes, D. G., Henriques, A. R., Santos-Dias, M., Nunes-da-Silva, C., Gonçalves, J., de Sousa, R. D., Abdulghani, S., Eletério, J., Braga, S. J., Soares, H., Branco, J. C., Canhão, H. & Rodrigues, A. M., 16 Jun 2021, In: Frontiers in public health. 9, 689919.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Coronavirus 85%
  • Seroepidemiologic Studies 75%
  • Pandemics 72%
  • Mental Health 53%
  3 Citations (Scopus)

  10 Downloads (Pure)

• Supercritical CO₂ Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots

  Baixinho, J. P., Anastácio, J. D., Ivasiv, V., Cankar, K., Bosch, D., Menezes, R., de Roode, M., Santos, C. N. D., Matias, A. A. & Fernández, N., 28 Apr 2021, In: Molecules. 26, 9, 2583.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chicory 100%
  • Sesquiterpenes 79%
  • Sesquiterpene Lactone 77%
  • Lactones 75%
  • Antiinflammatory 55%
  10 Citations (Scopus)

  6 Downloads (Pure)

• Surgical versus transcatheter aortic valve replacement in low-risk patients: A long-term propensity score-matched analysis

  Brízido, C., Madeira, M., Brito, J., Madeira, S., Campante Teles, R., Raposo, L., Mesquita Gabriel, H., Nolasco, T., de Araújo Gonçalves, P., Sousa-Uva, M., Abecasis, M., de Sousa Almeida, M., Neves, J. P. & Mendes, M., 1 Dec 2021, In: Catheterization and Cardiovascular Interventions. 98, 7, p. E1033 - E1043

  Research output: Contribution to journal › Article › peer-review

  • Transcatheter Aortic Valve Replacement 100%
  • Propensity Score 86%
  • Aortic Valve 40%
  • Surgical Instruments 39%
  • Mortality 20%
  1 Citation (Scopus)

• Synapses have autophagy under control

  Almeida, C. G., 7 Jun 2021, In: Journal of Cell Biology. 220, 6, e202105008.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • Autophagosomes 100%
  • Dendrites 84%
  • Autophagy 78%
  • Synapses 75%
  • Axons 71%
  2 Downloads (Pure)

• Targeting senescent cells improves functional recovery after spinal cord injury

  Paramos-de-Carvalho, D., Martins, I., Cristóvão, A. M., Dias, A. F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A. & Saúde, L., 6 Jul 2021, In: Cell Reports. 36, 1, 109334.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cord 100%
  • Spinal Cord Injuries 77%
  • Disorder 34%
  • Zebrafish 33%
  • Cicatrix 27%
  21 Citations (Scopus)

  7 Downloads (Pure)

• Teaching Video NeuroImages: Infratentorial Multiple Sclerosis Relapse Presenting as Continuous Hemifacial Myokymia

  Salavisa, M., Serrazina, F., Pires, P. & Correia, A. S., 6 Jul 2021, In: Neurology. 97, 1, p. e111-e112

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  2 Citations (Scopus)

  16 Downloads (Pure)

• The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies

  Marinho, A. T., Batuca, J. R., Miranda, J. P., Caixas, U., Dias, C. G., Branco, T., Soto, K., Pinheiro, P., Bourbon, M., Marques, M. M., Antunes, A. M., Monteiro, E. C. & Pereira, S. A., Mar 2021, In: Pharmacological Research. 165, 105446.

  Research output: Contribution to journal › Article › peer-review

  • Nevirapine 100%
  • Apolipoproteins 87%
  • HDL Lipoproteins 78%
  • Apolipoprotein A-I 46%
  • Antibodies 41%

• The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy

  Lopes-Coelho, F., Martins, F., Hipólito, A., Mendes, C., Sequeira, C. O., Pires, R. F., Almeida, A. M., Bonifácio, V. D. B., Pereira, S. A. & Serpa, J., 10 May 2021, In: Frontiers in Oncology. 11, 656229.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ferroptosis 100%
  • Endothelial Cells 46%
  • Propranolol 36%
  • erastin 32%
  • chrysin 28%
  17 Citations (Scopus)

  7 Downloads (Pure)

• The association between 25-hydroxyvitamin d concentration and telomere length in the very-old: The newcastle 85+ study

  Hakeem, S., Mendonça, N., Aspray, T., Kingston, A., Martin-Ruiz, C., Robinson, L. & Hill, T. R., Dec 2021, In: Nutrients. 13, 12, 4341.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • telomeres 100%
  • Telomere 95%
  • Blood Cells 23%
  • cohort studies 19%
  • prospective studies 18%
  2 Citations (Scopus)

  7 Downloads (Pure)

• The challenges and facilitators of self-management in pediatric asthma

  Pité, H., Carvalho, S. & Morais-Almeida, M., 1 Apr 2021, In: Current opinion in allergy and clinical immunology. 21, 2, p. 135-143 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Self-Management 100%
  • Asthma 71%
  • Pediatrics 59%
  • Child 28%
  • Mobile Applications 24%
  3 Citations (Scopus)

• The Effect of ACTN3 and VDR Polymorphisms on Skeletal Muscle Performance in Axial Spondyloarthropathies

  Pimenta, I., Mateus, H., Rodrigues-Manica, S., Pinheiro-Torres, R., Neto, A., Domingues, L., Lage Crespo, C., Sardoo, A., Machado, P., Branco, J. C., Silva, S. N. & Pimentel-Santos, F. M., 11 Aug 2021, In: Frontiers in Genetics. 12, 688984.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Actinin 100%
  • Spondylarthropathies 99%
  • Calcitriol Receptors 88%
  • Skeletal Muscle 58%
  • Muscles 44%
  1 Citation (Scopus)

  4 Downloads (Pure)

• The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future

  Datta-Chaudhuri, T., Zanos, T., Chang, E. H., Olofsson, P. S., Bickel, S., Bouton, C., Grande, D., Rieth, L., Aranow, C., Bloom, O., Mehta, A. D., Civillico, G., Stevens, M. M., Głowacki, E., Bettinger, C., Schüettler, M., Puleo, C., Rennaker, R., Mohanta, S., Carnevale, D., & 15 othersConde, S. V., Bonaz, B., Chernoff, D., Kapa, S., Berggren, M., Ludwig, K., Zanos, S., Miller, L., Weber, D., Yoshor, D., Steinman, L., Chavan, S. S., Pavlov, V. A., Al-Abed, Y. & Tracey, K. J., 24 May 2021, In: Bioelectronic medicine. 7, 1, p. 7

  Research output: Contribution to journal › Article › peer-review

  • Medicine 100%
  • Technology 89%
  • Biomedical Research 34%
  • Industry 31%
  • Delivery of Health Care 20%

• The Natural Progression of Ankylosing Spondylitis After 4 Decades of Untreated Disease

  Neto, A., Figueira, R., Quintal, A. & Rodrigues, M., 1 Dec 2021, In: Jcr-Journal Of Clinical Rheumatology. 27, 8S, p. S783

  Research output: Contribution to journal › Comment/debate › peer-review

• The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing

  Vicente, M. M., Chaves-Ferreira, M., Jorge, J. M. P., Proença, J. T. & Barreto, V. M., 17 Sept 2021, In: Frontiers in Cell and Developmental Biology. 9, 718466.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Gene Editing 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 93%
  • Mutation Rate 43%
  • Bacteriophages 40%
  • Technology 26%
  8 Citations (Scopus)

  15 Downloads (Pure)

• The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis

  Pereira-Da-silva, T., Napoleão, P., Pinheiro, T., Selas, M., Silva, F., Ferreira, R. C. & Carmo, M. M., Jan 2021, In: Medicina (Lithuania). 57, 1, p. 1-13 13 p., 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • CD40 Ligand 100%
  • Atherosclerosis 65%
  • Lower Extremity 43%
  • Coronary Artery Disease 27%
  • Carotid Artery Diseases 16%
  3 Citations (Scopus)

  5 Downloads (Pure)

• The right time for senescence

  De-Carvalho, D. P., Jacinto, A. & Saúde, L., Nov 2021, In: eLife. 10, e72449.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Physiological Role 100%
  • Cellular Senescence 29%
  • Time 29%
  • Biological Phenomena 26%
  • Artifacts 26%
  31 Citations (Scopus)

  6 Downloads (Pure)

• The role of high-density lipoprotein in the regulation of the immune response: implications for atherosclerosis and autoimmunity

  Fernandes das Neves, M., Batuca, J. R. & Delgado Alves, J., Oct 2021, In: Immunology. 164, 2, p. 231 - 241

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • HDL Lipoproteins 100%
  • Autoimmunity 92%
  • Atherosclerosis 76%
  • Cholesterol 26%
  • Cell Membrane 25%
  8 Citations (Scopus)

  47 Downloads (Pure)

• The role of muscle in the susceptibility and progression of axial Spondyloarthritis: The MyoSpA Study Protocol

  Sardoo, A. M., Neto, A., Pinheiro Torres, R., Rodrigues-Manica, S., Domingues, L., Lage Crespo, C., Lagoas-Gomes, J., Mascarenhas, V., Mendes, C. S., Galzerano, A., Fernandes de Almeida, S., Sepriano, A., Ramiro, S., Masi, A. T., Nair, K., Costa, J., Alexandre, B. M., Vassilevskaia, T., Cunha, C. V., Sobral, D., & 3 othersBranco, J. C., Gomes-Alves, P. & Pimentel-Santos, F. M., 29 Dec 2021, In: Acta Reumatológica Portuguesa. 46, 4, p. 342-349 8 p., 1537.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Muscles 100%
  • Inducer 96%
  • Biological Marker 74%
  • Paraspinal Muscles 74%
  • Protein 68%
  3 Downloads (Pure)

• The role of the Notch pathway in the pathogenesis of systemic sclerosis: clinical implications

  Seguro Paula, F. & Delgado Alves, J., 2021, In: Expert Review of Clinical Immunology. 17, 12, p. 1257 - 1267

  Research output: Contribution to journal › Review article › peer-review

  • Systemic Scleroderma 100%
  • Blood Vessels 41%
  • Fibrosis 26%
  • Expert Testimony 18%
  • Chronic Disease 12%

• The Selective Advantage of the lac Operon for Escherichia coli Is Conditional on Diet and Microbiota Composition

  Pinto, C., Melo-Miranda, R., Gordo, I. & Sousa, A., 21 Jul 2021, In: Frontiers in Microbiology. 12, 709259.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lac Operon 100%
  • Lactose 93%
  • Microbiota 78%
  • Escherichia coli 55%
  • Diet 54%
  3 Citations (Scopus)

  14 Downloads (Pure)

• The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

  Heredia, F., Volonté, Y., Pereirinha, J., Fernandez-Acosta, M., Casimiro, A. P., Belém, C. G., Viegas, F., Tanaka, K., Menezes, J., Arana, M., Cardoso, G. A., Macedo, A., Kotowicz, M., Prado Spalm, F. H., Dibo, M. J., Monfardini, R. D., Torres, T. T., Mendes, C. S., Garelli, A. & Gontijo, A. M., Dec 2021, In: Nature Communications. 12, 1, 3328.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ecdysone 100%
  • Instinct 95%
  • steroids 94%
  • hormones 88%
  • epidermis 87%
  6 Citations (Scopus)

  9 Downloads (Pure)

• TNF alpha Controls the Delicate Balance between Erythropoiesis and Stem Cell Exhaustion during Inflammatory Stress

  Guerra, A., Lo Presti, V., Martins, A. C., Castracani, C. C., Gupta, R., Oikonomidou, R., O'Hara, E., Casu, C., Bennett, L., Paulson, R., Kurrre, P., Rivella, S. & Gozzelino, R., 23 Nov 2021, In: Blood. 138

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage

  Coelho, I., Duarte, N., Barros, A., Macedo, M. P. & Penha-Gonçalves, C., 8 Feb 2021, In: Frontiers in Immunology. 11, 616044.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Endothelial Cells 100%
  • Macrophages 94%
  • Liver 69%
  • Kupffer Cells 36%
  • Wounds and Injuries 29%
  26 Citations (Scopus)

  13 Downloads (Pure)

• Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

  Melo, B. F., Prieto-Lloret, J., Cabral, M. D., Martins, F. O., Martins, I. B., Sacramento, J. F., Ruivo, P., Carvalho, T. & Conde, S. V., 15 Mar 2021, In: Scientific Reports. 11, 1, 6052.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pulmonary Artery 100%
  • Aorta 95%
  • Type 2 Diabetes Mellitus 82%
  • Blood Vessels 64%
  • Prediabetic State 31%
  3 Citations (Scopus)

  4 Downloads (Pure)

• TyPed study: Natalizumab for the treatment of pediatric-onset multiple sclerosis in Portugal

  Palavra, F., Figueiroa, S., Correia, A. S., Tapadinhas, F., Cerqueira, J., Guerreiro, R. P., de Sá, J., Sá, M. J., Almeida, S., Mota, P. & Sousa, L., Jun 2021, In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 51, 102865.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Natalizumab 100%
  • Portugal 85%
  • Multiple Sclerosis 61%
  • Pediatrics 44%
  • JC Virus 13%
  5 Citations (Scopus)

  9 Downloads (Pure)

• Unraveling the relevance of arl gtpases in cutaneous melanoma prognosis through integrated bioinformatics analysis

  Brito, C., Costa‐silva, B., Barral, D. C. & Pojo, M., 1 Sept 2021, In: International Journal of Molecular Sciences. 22, 17, 9260.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ribosylation 100%
  • T-cells 92%
  • prognosis 92%
  • GTP Phosphohydrolases 71%
  • Bioinformatics 68%
  3 Citations (Scopus)

  46 Downloads (Pure)

• Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss

  Burrinha, T., Martinsson, I., Gomes, R., Terrasso, A. P., Gouras, G. K. & Almeida, C. G., May 2021, In: Journal of Cell Science. 134, 9, jcs255752.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid beta-Protein Precursor 100%
  • Drive 88%
  • Endocytosis 87%
  • Amyloid 81%
  • Synapses 79%
  19 Citations (Scopus)

• Urolithin B protects pancreatic beta cells against IAPP proteotoxicity: a potential strategy for dietary interventions in diabetes

  Raimundo, A. F., Ferreira, S., Brito, J., Silva, M., Dos Santos, C. N. & Menezes, R., Sept 2021, In: Diabetologia. 64, SUPPL 1, p. 197-197

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Urolithins: Diet-derived bioavailable metabolites to tackle diabetes

  Raimundo, A. F., Ferreira, S., Tomás-Barberán, F. A., Santos, C. N. & Menezes, R., Dec 2021, In: Nutrients. 13, 12, 4285.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Hydrolyzable Tannins 100%
  • Ellagic Acid 91%
  • Phenols 84%
  • isourolithin A 69%
  • diabetes 66%
  14 Citations (Scopus)

  73 Downloads (Pure)

• Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts

  Sánchez-Maldonado, J. M., Cáliz, R., López-Nevot, M. Á., Cabrera-Serrano, A. J., Moñiz-Díez, A., Canhão, H., Ter Horst, R., Quartuccio, L., Sorensen, S. B., Glintborg, B., Hetland, ML., Filipescu, I., Pérez-Pampin, E., Conesa-Zamora, P., Swierkot, J., den Broeder, A. A., De Vita, S., Petersen, E. R. B., Li, Y., Ferrer, M. A., & 9 othersEscudero, A., Netea, MG., Coenen, M. J. H., Andersen, V., Fonseca, J. E., Jurado, M., Bogunia-Kubik, K., Collantes, E. & Sainz, J., 27 Oct 2021, In: Frontiers in Immunology. 12, 672255.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Tumor Necrosis Factor Inhibitors 82%
  • Rheumatoid Factor 79%
  • Rheumatoid Arthritis 79%
  • Meta-Analysis 71%
  3 Citations (Scopus)

  2 Downloads (Pure)

• VALIDATION OF GWAS-IDENTIFIED VARIANTS FOR ANTI-TNF DRUG RESPONSE IN RHEUMATOID ARTHRITIS: A META-ANALYSIS OF THREE LARGE COHORTS

  Sanchez-Maldonado, J. M., Caliz Caliz, R., Lopez-Nevot, M. A., Moniz-Diez, A., Cabrera-Serrano, A. J., Canhao, H., Ter Horst, R., Escudero Contreras, A., Sorensen, S., Hetland, M. L., Ferrer Gonzalez, M. A., Glintborg, B., Filipescu, I., Perez-Pampin, E., Conesa-Zamora, P., Swierkot, J., Den Broeder, A., De Vita, S., Hove Jaconsen, S. E., Quartuccio, L., & 8 othersLi, Y., Netea, M., Coenen, M. J. H., Andersen, V., Fonseca, J. E., Bogunia-Kubik, K., Collantes Estevez, E. & Sainz, J., Jun 2021, In: Annals of the rheumatic diseases. 80, p. 9-10

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Variants in STXBP3 Are Associated With Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation

  Ouahed, J., Kelsen, J. R., Spessott, W. A., Kooshesh, K., Sanmillan, M. L., Dawany, N., Sullivan, K. E., Hamilton, K., Slowik, V., Nejentsev, S., Neves, J. F., Flores, H., Chung, W. K., Wilson, A., Yeboa, K. A., Wou, K., Jain, P., Field, M., Tollefson, S., Dent, M. H., & 30 othersLi, D., Naito, T., McGovern, D. P. B., Kwong, A. C., Taliaferro, F., Ordovas-Montanes, J., Horwitz, B., Kotlarz, D., Klein, C., Evans, J., Dorsey, J., Warner, N., Elkadri, A., Muise, A. M., Goldsmith, J., Thompson, B., Engelhardt, K. R., Cant, A. J., Hambleton, S., Barclay, A., Toth-Petroczy, A., Vuzman, D., Carmichael, N., Bodea, C., Cassa, C. A., Devoto, M., Maas, R. L., Behrens, E. M., Giraudo, C. G. & Snapper, S. B., Nov 2021, In: JOURNAL OF CROHNS & COLITIS. 15, 11, p. 1908–1919

  Research output: Contribution to journal › Article › peer-review

  • Qa-SNARE Proteins 100%
  • Bilateral Hearing Loss 95%
  • Sensorineural Hearing Loss 79%
  • Inflammatory Bowel Diseases 66%
  • Carrier Proteins 59%
  6 Citations (Scopus)