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Research Output 1994 2019

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Article
2019
1 Citation (Scopus)

Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling

Quast, R. B., Fatemi, F., Kranendonk, M., Margeat, E. & Truan, G., Mar 2019, In : Chembiochem. 20, 5, p. 659-666

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
Energy Transfer
Energy transfer
Labeling
Coloring Agents

A multi-endpoint approach to the combined toxic effects of patulin and ochratoxin a in human intestinal cells

Assunção, R., Pinhão, M., Loureiro, S., Alvito, P. & Silva, M. J., 1 Oct 2019, In : Toxicology Letters. 313, p. 120-129 10 p.

Research output: Contribution to journalArticle

Patulin
Ochratoxins
Mycotoxins
Poisons
Cytotoxicity

Biological impact of metal nanomaterials in relation to their physicochemical characteristics

Louro, H., Saruga, A., Santos, J., Pinhão, M. & Silva, M. J., 1 Apr 2019, In : Toxicology In Vitro. 56, p. 172-183 12 p.

Research output: Contribution to journalArticle

Extraction of tomato by-products’ bioactive compounds using ohmic technology

Coelho, M., Pereira, R., Rodrigues, A. S., Teixeira, J. A. & Pintado, M. E., 1 Sep 2019, In : Food and Bioproducts Processing. 117, p. 329-339 11 p.

Research output: Contribution to journalArticle

Lycopersicon esculentum
byproducts
Byproducts
ohmic heating
tomatoes
2 Citations (Scopus)

Insights into the population structure and pan-genome of Haemophilus influenzae

Pinto, M., González-Díaz, A., Machado, M. P., Duarte, S., Vieira, L., Carriço, J. A., Marti, S., Bajanca-Lavado, M. P. & Gomes, J. P., Jan 2019, In : Infection Genetics And Evolution. 67, p. 126-135 10 p.

Research output: Contribution to journalArticle

Haemophilus influenzae
Genome
Haemophilus influenzae type b
Population
Single Nucleotide Polymorphism
1 Citation (Scopus)
Plasticizers
Cytotoxicity
Cells
Liver
DNA-Formamidopyrimidine Glycosylase
Open Access
Absenteeism
Health Services Accessibility
Food Supply
food
health care
Open Access
File
MicroRNAs
Drug Resistance
Neoplasms
Small Untranslated RNA
3' Untranslated Regions
Open Access
File
MicroRNAs
Drug Resistance
Doxorubicin
Breast Neoplasms
Real-Time Polymerase Chain Reaction
1 Citation (Scopus)
Philadelphia Chromosome
Genetic Predisposition to Disease
Caspases
Population
Genes

Thyroid cancer: The quest for genetic susceptibility involving dna repair genes

Santos, L. S., Gomes, B. C., Bastos, H. N., Gil, O. M., Azevedo, A. P., Ferreira, T. C., Limbert, E., Silva, S. N. & Rueff, J., 1 Aug 2019, In : Genes. 10, 8, 586.

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Thyroid Neoplasms
Single Nucleotide Polymorphism
DNA Repair
Genes
2018

Atypical haematological presentation in a case of polycythaemia vera with a new variant mutation detected in exon 12: c.1605G>T (p.Met535Ile)

Pita, A. S. A., Azevedo, A. P., Reichert, A., Silva, C. J. P. D., Henriques, V., Mendes, D. S., Reis, A. M. B., Cerqueira, R., Torres, F. & Viana, J. F., Feb 2018, In : Journal of Clinical Pathology. 71, 2, p. 180-184 5 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Exons
Mutation
Polycythemia
Janus Kinase 2
2 Citations (Scopus)

Bisoprolol-induced thrombocytopenia: A case report

Mousinho, F., Mendes, T., Sousa e Santos, P., Azevedo, A. P., Mousinho, G., Malcata, C., Viegas, E., Madureira, B., Falcão, F., Gomes, A. P. & Lima, F., Apr 2018, In : Journal of Clinical Pharmacy and Therapeutics. 43, 2, p. 280-283 4 p.

Research output: Contribution to journalArticle

Bisoprolol
Thrombocytopenia
Pharmaceutical Preparations
Bone Marrow Diseases
Idiopathic Thrombocytopenic Purpura

Concomitant presence of JAK2V617F mutation and BCR-ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report)

Mousinho, F., Azevedo, A. P., Mendes, T., Sousa E Santos, P., Cerqueira, R., Matos, S., Santos, S., Ramos, S., Viana, J. F. & Lima, F., 1 Jul 2018, In : Molecular Medicine Reports. 18, 1, p. 1001-1006 6 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTPase-Activating Proteins
Essential Thrombocythemia
Chromosomes
Protein-Tyrosine Kinases
4 Downloads (Pure)
Open Access
File
NADPH-Ferrihemoprotein Reductase
Osmolar Concentration
7 Citations (Scopus)

Dissecting whole-genome sequencing-based online tools for predicting resistance in Mycobacterium tuberculosis: can we use them for clinical decision guidance?

Macedo, R., Nunes, A., Portugal, I., Duarte, S., Vieira, L. & Gomes, J. P., May 2018, In : Tuberculosis. 110, p. 44-51 8 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Tuberculosis
Genome
Computational Biology
Genetic Databases
1 Citation (Scopus)
Critical Pathways
Hydroxyurea
Caspases
DNA Repair
Polymorphism

Evaluating the genotoxicity of cellulose nanofibrils in a co-culture of human lung epithelial cells and monocyte-derived macrophages

Ventura, C., Lourenço, A. F., Sousa-Uva, A., Ferreira, P. J. T. & Silva, M. J., 1 Jul 2018, In : Toxicology Letters. 291, p. 173-183 11 p.

Research output: Contribution to journalArticle

Macrophages
Coculture Techniques
Cellulose
Epithelial Cells
Lung
2 Citations (Scopus)
alternative medicine
herbal medicines
flavorings
Risk assessment
functional foods

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Esteves, F., Campelo, D., Urban, P., Bozonnet, S., Lautier, T., Rueff, J., Truan, G. & Kranendonk, M., Dec 2018, In : Biochemical pharmacology. 158, p. 134-140 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Cytochromes
Cytochrome P-450 Enzyme System
Assays
Bacteria
1 Citation (Scopus)
4 Downloads (Pure)

Mismatch repair single nucleotide polymorphisms and thyroid cancer susceptibility

Santos, L. S., Silva, S. N., Gil, O. M., Ferreira, T. C., Limbert, E. & Rueff, J., May 2018, In : Oncology Letters. 15, 5, p. 6715-6726 12 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Mismatch Repair
Thyroid Neoplasms
Single Nucleotide Polymorphism
Genotype
Genetic Predisposition to Disease
2 Citations (Scopus)

Molecular epidemiology and risk factors of carbapenemase-producing Enterobacteriaceae isolates in Portuguese hospitals: Results From European survey on carbapenemase-producing Enterobacteriaceae (EuSCAPE)

Manageiro, V., Romão, R., Moura, I. B., Sampaio, D. A., Vieira, L., Ferreira, E. & Caniça, M., 27 Nov 2018, In : Frontiers in Microbiology. 9, NOV, 2834.

Research output: Contribution to journalArticle

Open Access
File
Molecular Epidemiology
Enterobacteriaceae
Escherichia coli
Portugal
Clone Cells
4 Citations (Scopus)

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

Lobo, L., Cabral, L. I. L., Sena, M. I., Guerreiro, B., Rodrigues, A. S., De Andrade-Neto, V. F., Cristiano, M. L. S. & Nogueira, F., 3 Apr 2018, In : Malaria Journal. 17, 1, 145.

Research output: Contribution to journalArticle

Open Access
Plasmodium falciparum
Antimalarials
Plasmodium berghei
Parasitemia
Tetraoxanes
4 Downloads (Pure)
Open Access
File
NADPH-Ferrihemoprotein Reductase
hinges
cytochromes
Hinges
Cytochrome P-450 Enzyme System

Quercus based coffee-like beverage: effect of roasting process and functional characterization

Coelho, M., Silva, S., Rodríguez-Alcalá, L. M., Oliveira, A., Costa, E. M., Borges, A., Martins, C., Rodrigues, A. S. & Pintado, M. M. E., Mar 2018, In : Journal of Food Measurement and Characterization. 12, 1, p. 471-479 9 p.

Research output: Contribution to journalArticle

Quercus
Coffee
Beverages
roasting
Fatty acids
Proximal Kidney Tubule
Facilitative Glucose Transport Proteins
Accessories
Glucose
Kidney
2017
6 Citations (Scopus)

Analysis of Pelagia noctiluca proteome Reveals a Red Fluorescent Protein, a Zinc Metalloproteinase and a Peroxiredoxin

Frazao, B., Campos, A., Osorio, H., Thomas, B., Leandro, S., Teixeira, A., Vasconcelos, V. & Antunes, A., Apr 2017, In : Protein Journal. 36, 2, p. 77-97 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
5 Downloads (Pure)

BCR-ABL V280G mutation, potential role in imatinib resistance: First case report

Azevedo, A. P., Reichert, A., Afonso, C., Alberca, M. D., Tavares, P. & Lima, F., 2017, In : Clinical Medicine Insights: Oncology. 11, 1179554917702870.

Research output: Contribution to journalArticle

Open Access
File
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Disease Management
Drug Resistance
Protein-Tyrosine Kinases
3 Citations (Scopus)
14 Downloads (Pure)
Open Access
File
Genetic Predisposition to Disease
DNA Repair
Alleles
DNA Glycosylases
X-Rays
1 Citation (Scopus)
14 Downloads (Pure)

Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome

Feliciano, A., Vaz, F., Valentim-Coelho, C., Torres, V. M., Silva, R., Prosinecki, V., Alexandre, B. M., Almeida, A., Almeida-Marques, C., Carvalho, A. S., Matthiesen, R., Malhotra, A., Pinto, P., Bárbara, C. & Penque, D., Apr 2017, In : Data in brief. 11, p. 103-110 8 p.

Research output: Contribution to journalArticle

Open Access
File
Obstructive Sleep Apnea
Proteome
Erythrocytes
Two-Dimensional Difference Gel Electrophoresis
Proteins
3 Citations (Scopus)

Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells: Correlation with polysomnographic and metabolic parameters

Feliciano, A., Vaz, F., Torres, V. M., Valentim-Coelho, C., Silva, R., Prosinecki, V., Alexandre, B. M., Carvalho, A. S., Matthiesen, R., Malhotra, A., Pinto, P., Bárbara, C. & Penque, D., Feb 2017, In : Biochimica Et Biophysica Acta. 1863, 2, p. 621-629 9 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Obstructive Sleep Apnea
Oxidation-Reduction
Erythrocytes
Pressure
5 Citations (Scopus)
p53 Genes
Genetic Predisposition to Disease
Pancreatitis
Single Nucleotide Polymorphism
Oxidative Stress
18 Citations (Scopus)

MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2

Coady, M. J., El Tarazi, A., Santer, R., Bissonnette, P., Sasseville, L. J., Calado, J., Lussier, Y., Dumayne, C., Bichet, D. G. & Lapointe, J-Y., Jan 2017, In : Journal Of The American Society Of Nephrology. 28, 1, p. 85-93 8 p.

Research output: Contribution to journalArticle

Kidney
Glucose
A Kinase Anchor Proteins
Sodium-Glucose Transporter 2
Renal Glycosuria
3 Citations (Scopus)
9 Downloads (Pure)

Prevalence of the Janus kinase 2 V617F mutation in Philadelphia‑negative myeloproliferative neoplasms in a Portuguese population

Azevedo, A. P., Silva, S., Reichert, A., Lima, F., Júnior, E. & Rueff, J., Oct 2017, In : Biomedical Reports. 7, 4, p. 370-376 7 p.

Research output: Contribution to journalArticle

Open Access
File
Janus Kinase 2
Essential Thrombocythemia
Polycythemia Vera
Mutation
Primary Myelofibrosis
13 Downloads (Pure)

PROS1 novel splice-site variant decreases protein S expression in patients from two families with thrombotic disease

Menezes, J., Ventura, C., Costa, J. M., Parreira, E., Romao, L. & Goncalves, J., Dec 2017, In : CLINICAL CASE REPORTS. 5, 12, p. 2062-2065 4 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
12 Downloads (Pure)

Rubella in Sub-Saharan Africa and sensorineural hearing loss: a case control study

Caroça, C., Vicente, V., Campelo, P., Chasqueira, M., Caria, H., Nunes Silva, S., Paixão, P. & Paço, J., 1 Feb 2017, In : BMC Public Health. 17, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Open Access
File
Rubella
Sensorineural Hearing Loss
Africa South of the Sahara
Case-Control Studies
Congenital Rubella Syndrome
7 Downloads (Pure)

The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome

Kiaco, K., Rodrigues, A. S., do Rosário, V., Gil, J. P. & Lopes, D., 21 Sep 2017, In : Malaria Journal. 16, 1, p. 383

Research output: Contribution to journalArticle

Open Access
File
Cytochrome P-450 CYP3A
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Malaria
Angola
4 Citations (Scopus)
30 Downloads (Pure)

The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: The critical role of ionic strength

Campelo, D., Lautier, T., Urban, P., Esteves, F., Bozonnet, S., Truan, G. & Kranendonk, M., 30 Oct 2017, In : Frontiers in Pharmacology. 8, OCT, p. Online 13 p., 755.

Research output: Contribution to journalArticle

Open Access
File
NADPH-Ferrihemoprotein Reductase
Osmolar Concentration
Salts
Cytochromes c
Oxidation-Reduction
6 Citations (Scopus)

Toxicity screening of a novel poly(methylmethacrylate)-Eudragit nanocarrier on L929 fibroblasts

Graça, D., Louro, H., Santos, J., Dias, K., Almeida, A. J., Gonçalves, L., Silva, M. J. & Bettencourt, A., 5 Jul 2017, In : Toxicology Letters. 276, p. 129-137 9 p.

Research output: Contribution to journalArticle

Methylmethacrylate
Fibroblasts
Toxicity
Screening
Nanosystems
1 Citation (Scopus)

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia

Ferrão, J., Silva, M., Gonçalves, L., Gomes, S., Loureiro, P., Coelho, A., Miranda, A., Seuanes, F., Reis, A. B., Pina, F., Maia, R., Kjöllerström, P., Monteiro, E., Lacerda, J. F., Lavinha, J., Gonçalves, J. & Faustino, P., Nov 2017, In : Annals Of Hematology. 96, 11, p. 1921-1929 9 p.

Research output: Contribution to journalArticle

alpha-Thalassemia
Thalassemia
Globins
Gene Deletion
Multigene Family
2016
21 Citations (Scopus)

Challenges in risk assessment of multiple mycotoxins in food

Assuncao, R., Silva, M. J. & Alvito, P., 2016, In : World Mycotoxin Journal. 9, 5, SI, p. 791-811 21 p.

Research output: Contribution to journalArticle

Mycotoxins
Risk assessment
mycotoxins
risk assessment
Food
2 Citations (Scopus)
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
2-amino-3-methylimidazo(4,5-f)quinoline
Mutagens
NADPH-Ferrihemoprotein Reductase
16 Citations (Scopus)

Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties

Louro, H., Pinhao, M., Santos, M. J., Tavares, A., Vital, N. & Silva, M. J., 16 Nov 2016, In : Toxicology Letters. 262, p. 123-134 12 p.

Research output: Contribution to journalArticle

Benchmarking
Carbon Nanotubes
Assays
Cells
Cell Line
1 Citation (Scopus)

Genetic Basis of Nonsyndromic Sensorineural Hearing Loss in the Sub-Saharan African Island Population of São Tomé and Príncipe: The Role of the DFNB1 Locus?

Caroça, C., De Matos, T. M., Ribeiro, D., Lourenço, V., Martins, T., Campelo, P., Fialho, G., Nunes Silva, S., Paço, J. & Caria, H., Aug 2016, In : Omics-A Journal Of Integrative Biology. 20, 8, p. 449-455 7 p.

Research output: Contribution to journalArticle

Audition
Islands
Population
Hearing Loss
Mutation
3 Citations (Scopus)

Glycidamide genotoxicity modulated by Caspases genes polymorphisms

de Lima, J. P., Silva, S. N., Rueff, J. & Pingarilho, M., 1 Aug 2016, In : Toxicology In Vitro. 34, p. 123-127 5 p.

Research output: Contribution to journalArticle

Caspases
Polymorphism
Genes
DNA Damage
Sister Chromatid Exchange
12 Citations (Scopus)

Instability of the human cytochrome P450 reductase A287P variant is the major contributor to its Antley-Bixler syndrome-like phenotype

McCammon, K. M., Panda, S. P., Xia, C., Kim, J. J. P., Moutinho, D., Kranendonk, M., Auchus, R. J., Lafer, E. M., Ghosh, D., Martasek, P., Kar, R., Masters, B. S. & Roman, L. J., 23 Sep 2016, In : Journal of Biological Chemistry. 291, 39, p. 20487-20502 16 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
NADPH-Ferrihemoprotein Reductase
Oxidoreductases
Differential Scanning Calorimetry
Proteins
1 Citation (Scopus)
Human Genome
Viruses
Genes
HIV
Virus Integration
14 Citations (Scopus)

In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex

Martins, M., Baptista, PV., Mendo, A. S., Correia, C., Videira, P., Rodrigues, AS., Muthukumaran, J., Santos-Silva, T., Silva, A., Guedes da Silva, M. F. C., Gigante, J., Duarte, A., Gajewska, M. & Fernandes, AR., 2016, In : Molecular Biosystems. 12, 3, p. 1015-1023 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

MicroRNAs and Cancer Drug Resistance

Gomes, B. C., Rueff, J. & Rodrigues, A. S., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. 137-62 26 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Small Untranslated RNA
Neoplasms
Epithelial-Mesenchymal Transition