Multifunctional nanodevice reverses drug resistance - Nature Reviews Drug Discovery

Description

Multidrug resistance in cancer cells is most commonly due to the expression of energy-dependent drug transporters that are able to efflux a variety of structurally and functionally unrelated drugs. Reporting in PNAS, João Conde and colleagues now present an implantable nanogold-containing hydrogel that can sense and silence multidrug resistance genes prior to drug release, and that reports on these events by emitting fluorescence.